scholarly journals New Pharmacological Opportunities for Betulinic Acid

Planta Medica ◽  
2017 ◽  
Vol 84 (01) ◽  
pp. 8-19 ◽  
Author(s):  
José Ríos ◽  
Salvador Máñez
Keyword(s):  
Metabolic Syndrome ◽  
Natural Product ◽  
Betulinic Acid ◽  
Therapeutic Potential ◽  
Present Review ◽  
Antitumor Effects ◽  
Pharmacological Activities ◽  
Naturally Occurring ◽  
Wide Range ◽  
Birch Trees

AbstractBetulinic acid is a naturally occurring pentacyclic lupane-type triterpenoid usually isolated from birch trees, but present in many other botanical sources. It is found in different plant organs, both as a free aglycon and as glycosyl derivatives. A wide range of pharmacological activities has been described for this triterpenoid, including antiviral and antitumor effects. In addition, several other interesting properties have been identified in the fields of immunity and metabolism, namely antidiabetic, antihyperlipidemic, and anti-inflammatory activities. Taken together, these latter three properties make betulinic acid a highly interesting prospect for treating metabolic syndrome. The present review focuses on the therapeutic potential of this agent, along with several of its semisynthetic derivatives, which could open new frontiers in the use of natural product-based medicines.

Ethnomedicinal Uses, Phytochemistry and Pharmacology of Carica papaya Plant: A Compendious Review

2019 ◽  
Vol 16 (5) ◽  
pp. 463-480 ◽  
Author(s):  
Manpreet Kaur ◽  
Naveen Chandra Talniya ◽  
Seema Sahrawat ◽  
Arvind Kumar ◽  
Elena E. Stashenko
Keyword(s):  
Carica Papaya ◽  
Therapeutic Potential ◽  
Industrial Applications ◽  
Present Review ◽  
Future Research ◽  
Pharmacological Activities ◽  
Traditional System ◽  
Wide Range ◽  
Microbial Infections ◽  
Ethnomedicinal Uses

Medicinal properties of papaya (Carica papaya Linn.) fruit and other parts are wellknown in the traditional system of medicine. Papaya plant originated in Central America and now grown in tropical areas of worldwide, most particularly in Africa and Asia. Studies validate that, papaya has several pharmacological activities, such as antioxidant, antiulcer, antibacterial, woundhealing, anti-inflammatory and anti-sickling, just to name a few. The present review article provides the explicit and updated information on botanical aspects, ethnomedicinal uses, phytochemistry and pharmacological activities of C. papaya plant in order to explore their therapeutic potential. This review conducted a systematic search on C. papaya through electronic database search (Google Scholar, PubMed, SciFinder, Scopus, Science Direct, and Web of Science) and a library search for articles published in peer-reviewed journals, until January of 2018. Constituents of papaya plant belongs to different chemical classes that include alkaloids, flavonoids, terpenoids, saponins, steroids, tannin, vitamins, quinones, minerals and others. Experimental evidence confirmed that these classes of compounds cure the microbial infections, diabetes, inflammatory, cytotoxic and liver disorders. Conclusively, the present review aimed to summarize the information of ethnomedicinal uses, phytochemistry and pharmacological activities to prevent and treat the wide range of diseases and disorders. The future research draws the attention of the researcher for intensive investigations relating to phytochemicals, pharmacological activities and industrial applications.

Therapeutic Potential of Cinnoline Core: A Comprehensive Review

2020 ◽  
Vol 20 (3) ◽  
pp. 196-218
Author(s):  
Rajiv K. Tonk ◽  
Sandhya Bawa ◽  
Deepak Kumar
Keyword(s):  
Heterocyclic Compounds ◽  
Therapeutic Potential ◽  
Biological Properties ◽  
Present Review ◽  
Natural Occurrence ◽  
Pharmacological Activities ◽  
Comprehensive Review ◽  
Wide Range ◽  
The Family ◽  
Almost All

Cinnoline or Benzo-pyridazine has its place in the family of fairly well-known benzfuseddiazine heterocycles. Because of its natural occurrence and synthetic exploration, cinnoline compounds validated its thought-provoking bioactivity through a number of research publications and patents during last few decades. A creative consideration has been rewarded to the synthesis of cinnoline based heterocyclic compounds, mostly due to their wide range of diverse pharmacological activities. The present review covers the principle approaches to the synthesis of cinnoline nucleus and almost all biological properties of 115 cinnoline derivatives reported during the last 65 years from natural and synthetic origin with 140 references.

scholarly journals Naturally Occurring Flavanones: An Overview

2008 ◽  
Vol 3 (8) ◽  
pp. 1934578X0800300 ◽  
Author(s):  
Goutam Brahmachari
Keyword(s):  
Present Review ◽  
Pharmacological Activities ◽  
Structural Pattern ◽  
Naturally Occurring ◽  
Plant Families ◽  
Biological And Pharmacological Activities

Flavanones are one of the most interesting naturally occurring flavonoids in view of their structural pattern as well as biological and pharmacological potentials. The present review deals with natural flavanones reported from 1998 to mid 2007, along with their biological and pharmacological activities. The review includes more than 160 new naturally occurring flavanones from 135 references. The reported flavonoids belong to thirty-six plant families.

scholarly journals CONNECTION APPROACHES BETWEEN TRADITIONAL AND MODERN PHARMACOLOGICAL PROFILE OF SHOREA ROBUSTA GAERTN. F.: A REVIEW

2018 ◽  
Vol 11 (9) ◽  
pp. 37
Author(s):  
Manish Pal Singh ◽  
Ravi Kumar
Keyword(s):  
Plant Extract ◽  
Therapeutic Potential ◽  
Present Review ◽  
Pharmacological Effects ◽  
Pharmacological Profile ◽  
Active Ingredients ◽  
Pharmacological Activities ◽  
Shorea Robusta ◽  
The Rich ◽  
Different Parts

Shorea robusta is regarded as an important medicine in Ayurveda. S. robusta Gaertn. f. belongs to family Dipterocarpaceae, and traditionally, it is used to treat wounds, ulcers, leprosy, cough, gonorrhea, earache, and headache and many more. The use of different parts of this plant such as leaves, resin, and bark as a medicament for the treatment of various conditions is well documented in literature. It is the rich source of flavonoids, saponins, steroids, tannins, phenols, etc. mainly triterpenoids, which play the prominent role for their therapeutic potential in the drug. These compounds are believed to be responsible for the pharmacological activities of plant extract. The present review clarified the main active ingredients and pharmacological effects of S. robusta as a promising plant as a result of effectiveness and safety. Further studies should be carried out this plant to discover the unrevealed part of it which may serve for the welfare of humankind.

scholarly journals The Therapeutic Potential of Apigenin

2019 ◽  
Vol 20 (6) ◽  
pp. 1305 ◽  
Author(s):  
Bahare Salehi ◽  
Alessandro Venditti ◽  
Mehdi Sharifi-Rad ◽  
Dorota Kręgiel ◽  
Javad Sharifi-Rad ◽  
...  
Keyword(s):  
Animal Models ◽  
Health Effects ◽  
Therapeutic Potential ◽  
Dietary Assessment ◽  
Functional Activities ◽  
Formulated Diet ◽  
Naturally Occurring ◽  
Wide Range ◽  
Health Promoting

Several plant bioactive compounds have exhibited functional activities that suggest they could play a remarkable role in preventing a wide range of chronic diseases. The largest group of naturally-occurring polyphenols are the flavonoids, including apigenin. The present work is an updated overview of apigenin, focusing on its health-promoting effects/therapeutic functions and, in particular, results of in vivo research. In addition to an introduction to its chemistry, nutraceutical features have also been described. The main key findings from in vivo research, including animal models and human studies, are summarized. The beneficial indications are reported and discussed in detail, including effects in diabetes, amnesia and Alzheimer’s disease, depression and insomnia, cancer, etc. Finally, data on flavonoids from the main public databases are gathered to highlight the apigenin’s key role in dietary assessment and in the evaluation of a formulated diet, to determine exposure and to investigate its health effects in vivo.

scholarly journals Natural Product Repertoire of the Genus Amphimedon

Marine Drugs ◽  
2018 ◽  
Vol 17 (1) ◽  
pp. 19 ◽  
Author(s):  
Nourhan Shady ◽  
Mostafa Fouad ◽  
Mohamed Salah Kamel ◽  
Tanja Schirmeister ◽  
Usama Abdelmohsen
Keyword(s):  
Secondary Metabolites ◽  
Natural Product ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
Marine Sponges ◽  
Rich Source ◽  
Undescribed Species ◽  
Pharmacological Activities ◽  
Wide Range ◽  
Complete Survey

Marine sponges are a very attractive and rich source in the production of novel bioactive compounds. The sponges exhibit a wide range of pharmacological activities. The genus Amphimedon consists of various species, such as viridis, compressa, complanata, and terpenensis, along with a handful of undescribed species. The Amphimedon genus is a rich source of secondary metabolites containing diverse chemical classes, including alkaloids, ceramides, cerebrososides, and terpenes, with various valuable biological activities. This review covers the literature from January 1983 until January 2018 and provides a complete survey of all the compounds isolated from the genus Amphimedon and the associated microbiota, along with their corresponding biological activities, whenever applicable.

scholarly journals 5-Azacytidine and Resveratrol Enhance Chondrogenic Differentiation of Metabolic Syndrome-Derived Mesenchymal Stem Cells by Modulating Autophagy

2019 ◽  
Vol 2019 ◽  
pp. 1-20 ◽  
Author(s):  
K. Marycz ◽  
J. M. Irwin Houston ◽  
C. Weiss ◽  
M. Röcken ◽  
K. Kornicka
Keyword(s):  
Metabolic Syndrome ◽  
Stem Cells ◽  
Chondrogenic Differentiation ◽  
Therapeutic Potential ◽  
Early Stage ◽  
Mitochondrial Dynamics ◽  
The Body ◽  
Stem Cell Population ◽  
Wide Range

Recently, metabolic syndrome (MS) has gained attention in human and animal metabolic medicine. Insulin resistance, inflammation, hyperleptinemia, and hyperinsulinemia are critical to its definition. MS is a complex cluster of metabolic risk factors that together exert a wide range of effects on multiple organs, tissues, and cells in the body. Adipose stem cells (ASCs) are multipotent stem cell population residing within the adipose tissue that is inflamed during MS. Studies have indicated that these cells lose their stemness and multipotency during MS, which strongly reduces their therapeutic potential. They suffer from oxidative stress, apoptosis, and mitochondrial deterioration. Thus, the aim of this study was to rejuvenate these cells in vitro in order to improve their chondrogenic differentiation effectiveness. Pharmacotherapy of ASCs was based on resveratrol and 5-azacytidine pretreatment. We evaluated whether those substances are able to reverse aged phenotype of metabolic syndrome-derived ASCs and improve their chondrogenic differentiation at its early stage using immunofluorescence, transmission and scanning electron microscopy, real-time PCR, and flow cytometry. Obtained results indicated that 5-azacytidine and resveratrol modulated mitochondrial dynamics, autophagy, and ER stress, leading to the enhancement of chondrogenesis in metabolically impaired ASCs. Therefore, pretreatment of these cells with 5-azacytidine and resveratrol may become a necessary intervention before clinical application of these cells in order to strengthen their multipotency and therapeutic potential.

Synthesis and Antitumor Activity of Novel [1,2,4,5]-tetrazepino[6,7-b] indole Derivatives: Marine Natural Product Hyrtioreticuline C and D Analogues

2018 ◽  
Vol 19 (1) ◽  
pp. 79-86 ◽  
Author(s):  
Zeinab A. Muhammad ◽  
Mohamed A.A. Radwan ◽  
Thoraya A. Farghaly ◽  
Hatem M. Gaber ◽  
Mahmuod M. Elaasser
Keyword(s):  
Natural Product ◽  
Carcinoma Cell ◽  
Biologically Active ◽  
Marine Natural Product ◽  
Basic Medium ◽  
Standard Drug ◽  
Reference Drug ◽  
Carcinoma Cell Lines ◽  
Naturally Occurring ◽  
Wide Range

Background: Several biologically active indole alkaloids have been isolated from marine organisms over the previous few years. Many scientsts interested in synthesis of the marine azepinoindole alkaloids due to their wide range of bioliogical activies. </P><P> Objective: We interested herein to synthesize a new series of some analogues of new naturally occurring azepinoindole alkaloids. </P><P> Method: A novel series of [1,2,4,5]tetrazepino[6,7-b]indoles, Marine natural product Hyrtioreticuline C and D analogues, were synthesized via the reaction of 3-hydrazonoindolin-2-one with hydrzaonoyl chlorides in basic medium. </P><P> Results: The spectral data of the products proved their structure. All new derivatives were tested against two carcinoma cell lines ((A-549 & HepG2)) in comparison with the well-known anticancer standard drug (cisplatin) and two derivatives from the tested compounds showed activity more potent than the reference drug. </P><P> Conclusion: We succeeded in synthesis of new antitumor active azepinoindole alkaloids.

scholarly journals Imperata cylindrica: A Review of Phytochemistry, Pharmacology, and Industrial Applications

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1454
Author(s):  
Young-Kyung Jung ◽  
Dongyun Shin
Keyword(s):  
Medicinal Plant ◽  
Therapeutic Potential ◽  
Chemical Constituents ◽  
Industrial Applications ◽  
Imperata Cylindrica ◽  
Pharmacological Activities ◽  
Wide Range ◽  
Pharmacological Studies

Imperata cylindrica is a medicinal plant native to southwestern Asia and the tropical and subtropical zones. To date, 72 chemical constituents have been isolated and identified from I. cylindrica Among these compounds, saponins, flavonoids, phenols, and glycosides are the major constituents. Investigations of pharmacological activities of I. cylindrica revealed that this edible medicinal herb exhibits a wide range of therapeutic potential including immunomodulatory, antibacterial, antitumor, anti-inflammatory, and liver protection activities both in vivo and in vitro. The purpose of this review is to provide an overview of I. cylindrica studies until 2019. This article also intends to review advances in the botanical, phytochemical, and pharmacological studies and industrial applications of I. cylindrica, which will provide a useful bibliography for further investigations and applications of I. cylindrica in medicines and foods.

Synthesis, Spectral Characterization and Biological Evaluation of Organotin(IV) Complexes of Aniline Derivatives of Naturally Occurring Betulinic Acid

2019 ◽  
Vol 41 (4) ◽  
pp. 725-725
Author(s):  
Sabiha Khanam Sabiha Khanam ◽  
Khadija Shahid Khadija Shahid ◽  
Muhammad Sirajuddin Muhammad Sirajuddin ◽  
Saqib Ali and Hameed Ullah Saqib Ali and Hameed Ullah
Keyword(s):  
Antioxidant Activity ◽  
Betulinic Acid ◽  
Antioxidant Activities ◽  
Biological Evaluation ◽  
Pharmacological Activities ◽  
Aniline Derivatives ◽  
Naturally Occurring ◽  
Ft Ir ◽  
Immense Potential ◽  
Derivatives Of

Betulinic acid (triterpene) has shown an immense potential towards the development of anticancer, antiviral, antimalarial, antifungal, antioxidant and antiprotozoal agents. Cis-platin (cytotoxic agent) has diverted attention of chemists towards organotin complexes with marked pharmacological activities. In present work aniline derivatives of Betulinic acid were synthesized followed by the synthesis of diorganotin and triorganotin metal complexes. These complexes were characterized by FT-IR and multinuclear NMR (1H and 13C) spectroscopy. The ligands and their organotin(IV) complexes were screened for antibacterial, antifungal and antioxidant activities. Compound L22SnMe2 was found with maximum antibacterial activity among the screened compounds. Compounds L12SnMe2 and L12SnPh2 were found with remarkable antifungal activity. Similarly L1, L12SnBu2, L2 and L22SnMe3 were remarked with good antioxidant activity.

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