Changes in Membrane Dielectric Properties of Porcine Kidney Cells Provide Insight into the Antiviral Activity of Glycine

Langmuir ◽  
2020 ◽  
Vol 36 (29) ◽  
pp. 8344-8356
Author(s):  
Sanaz Habibi ◽  
Pratik U. Joshi ◽  
Xue Mi ◽  
Caryn L. Heldt ◽  
Adrienne R. Minerick
Keyword(s):  
Dielectric Properties ◽  
Antiviral Activity ◽  
Kidney Cells ◽  
Porcine Kidney ◽  
Insight Into

Preparation, spectral properties and biological activities of 5-bromo-6-methyl-2'-deoxyuridine and 5-iodo-6-methyl-2'-deoxyuridine

1980 ◽  
Vol 45 (8) ◽  
pp. 2364-2370 ◽  
Author(s):  
Antonín Holý ◽  
Erik De Clercq
Keyword(s):  
Antiviral Activity ◽  
Spectral Properties ◽  
De Novo ◽  
Biological Activities ◽  
Rabbit Kidney ◽  
Kidney Cells ◽  
Cd Spectra ◽  
Methyl Derivatives ◽  
Primary Rabbit

Reaction of 3',5'-di-O-benzoyl-6-methyl-2'-deoxyuridine (IIa) with elementary bromine or iodine afforded 5-halogeno derivatives IIc and IId which on methanolysis gave 5-bromo-6-methyl-2'-deoxyurine (Ic) and 5-iodo-6-methyl-2'-deoxyurine (Id), respectively. The CD spectra of Ic, Id and 6-methyl-2'-deoxyuridine (Ia) are compared and discussed with regard to determination of the nucleoside conformation. Unlike 5-bromo- and 5-iodo-2'-deoxyuridine, the 6-methyl derivatives Ic and Id exhibit neither antibacterial nor antiviral activity. Nor do they exert any antimetabolic effect on the de novo DNA synthesis in primary rabbit kidney cells.

Fertilization state ofAscaris suumdetermined by electrorotation

2006 ◽  
Vol 80 (1) ◽  
pp. 25-31 ◽  
Author(s):  
C. Dalton ◽  
A.D. Goater ◽  
H.V. Smith
Keyword(s):  
Dielectric Properties ◽  
Physicochemical Properties ◽  
Parasitic Nematode ◽  
Invasive Technique ◽  
Non Invasive ◽  
Egg Morphology ◽  
Parasite Biology ◽  
Response Modelling ◽  
Non Destructive ◽  
Insight Into

AbstractElectrorotation is a non-invasive technique that is capable of detecting changes in the morphology and physicochemical properties of microorganisms. The first detailed electrorotation study of the egg (ovum) of a parasitic nematode, namelyAscaris suumis described to show that electrorotation can rapidly differentiate between fertilized and non-fertilized eggs. Support for this conclusion is by optical microscopy of egg morphology, and also from modelling of the electrorotational response. Modelling was used to determine differences in the dielectric properties of the unfertilized and fertilized eggs, and also to investigate specific differences in the spectra of fertilized eggs only, potentially reflecting embryogenesis. The potential of electrorotation as an investigative tool is shown, as undamaged eggs can be subjected to further non-destructive and destructive techniques, which could provide further insight into parasite biology and epidemiology.

Reply by the author to J. Korringa and R. J. S. Brown

Geophysics ◽  
1984 ◽  
Vol 49 (2) ◽  
pp. 203-203
Author(s):  
James Lange
Keyword(s):  
Dielectric Properties ◽  
Theoretical Model ◽  
Physical Properties ◽  
Porous Materials ◽  
Experimental Model ◽  
Volume Fraction ◽  
Dielectric Material ◽  
Microscopic Structure ◽  
Dielectric Fluids ◽  
Insight Into

An important feature of the dielectric properties of water in porous materials is that it does not behave like many other dielectric fluids of simpler microscopic structure. As a basis for evaluating the deviance of the dielectric properties of water, an experimental model is used in my paper. This experimental model is the volume fraction model and is determined from direct measurement. It involves no theoretical suppositions about the geometry of the composite dielectric material. This approach is taken to illustrate the unique physical properties of water rather than to adopt some theoretical model which depends upon some extraordinary insight into the “approximate” geometry of the composite dielectrics.

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