Intraperitoneal Administration of a Cisplatin-Loaded Nanogel through a Hybrid System Containing an Alginic Acid-Based Nanogel and an In Situ Cross-Linkable Hydrogel for Peritoneal Dissemination of Ovarian Cancer

SummaryPraeperitoneal administration of colloidal 198Au complicating the treatment of anascitic ovarian cancer is reported. Typical scintiscans and various clinical findings of muscle necrosis and radiation myositis are described. Administration of larger amount of saline solution preceding the radiogold instillation controlled by simultaneous scintiscanning are suggested as safety measures in patients when no ascitic fluid is present.

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Experimental study of antitumour activity and effects on leukocyte count of intraperitoneal administration and hyperthermic intraperitoneal chemoperfusion (HIPEC) with dioxadet in a rat model of ovarian cancer

Journal of Chemotherapy ◽

10.1179/1973947815y.0000000040 ◽

2016 ◽

Vol 28 (3) ◽

pp. 203-209 ◽

Cited By ~ 2

Author(s):

Vladimir Grigorjevich Bespalov ◽

Galina Sergeevna Kireeva ◽

Olesya Alexandrovna Belyaeva ◽

Konstantin Yurjevich Senchik ◽

Alexandr Nikolaevich Stukov ◽

...

Keyword(s):

Ovarian Cancer ◽

Experimental Study ◽

Rat Model ◽

Leukocyte Count ◽

Antitumour Activity ◽

Intraperitoneal Administration ◽

Intraperitoneal Chemoperfusion

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Malignant extracellular vesicles carrying MMP1 mRNA facilitate peritoneal dissemination in ovarian cancer

Nature Communications ◽

10.1038/ncomms14470 ◽

2017 ◽

Vol 8 (1) ◽

Cited By ~ 104

Author(s):

Akira Yokoi ◽

Yusuke Yoshioka ◽

Yusuke Yamamoto ◽

Mitsuya Ishikawa ◽

Shun-ichi Ikeda ◽

...

Keyword(s):

Ovarian Cancer ◽

Extracellular Vesicles ◽

Peritoneal Dissemination

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Targeted therapy - the intraperitoneal administration of cisplatin in ovarian cancer

Inpharma Weekly ◽

10.2165/00128413-199007260-00049 ◽

1990 ◽

Vol &NA; (726) ◽

pp. 20-21

Author(s):

&NA;

Keyword(s):

Ovarian Cancer ◽

Targeted Therapy ◽

Intraperitoneal Administration

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In situ studies on alginic acid synthesis and other aspects of the metabolism of Laminaria digitata

Canadian Journal of Botany ◽

10.1139/b72-023 ◽

1972 ◽

Vol 50 (1) ◽

pp. 177-184 ◽

Cited By ~ 10

Author(s):

Johan A. Hellebust ◽

Arne Haug

Keyword(s):

Amino Acids ◽

Time Course ◽

Alginic Acid ◽

Acid Synthesis ◽

Short Term ◽

Fresh Weight Basis ◽

Mannuronic Acid ◽

Guluronic Acid ◽

Rate Of Photosynthesis

Amino acids, particularly alanine and aspartate, become more strongly labeled than mannitol in short-term 14C-photoassimilation experiments. The amino acids are the most likely sources of carbon for alginic acid synthesis and respiration in the dark, in contrast to mannitol, which appears to be relatively unavailable. Temperature is very important in determining the rate of loss of recent photoassimilate in L. digitata. The rate of photosynthesis, on a fresh weight basis, is much higher for blades than for stipes.The time course for incorporation of photoassimilated carbon into alginate differs for the stipe and blade both in light and dark periods. Very little 14C enters alginate in blades in the dark, while alginate in stipes acquires considerable amounts of activity during dark periods. Alginate in both blade and stipe acquires 14C predominantly in mannuronic acid residues of their alginate during short-term photoassimilation periods, while guluronic acid residues become relatively more rapidly labeled during dark periods.

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