Nano Spray Drying Technique as a Novel Approach To Formulate Stable Econazole Nitrate Nanosuspension Formulations for Ocular Use

2016 ◽  
Vol 13 (9) ◽  
pp. 2951-2965 ◽  
Author(s):  
Amr Maged ◽  
Azza A. Mahmoud ◽  
Mahmoud M. Ghorab
2012 ◽  
Vol 436 (1-2) ◽  
pp. 873-876 ◽  
Author(s):  
Krzysztof J. Paluch ◽  
Lidia Tajber ◽  
Bożena Adamczyk ◽  
Owen I. Corrigan ◽  
Anne Marie Healy
Keyword(s):  

2021 ◽  
Vol 12 (4) ◽  
pp. 4920-4928

Spray drying is a well-known method for preparing dried extracts from herbs. Rehmannia glutinosa root and Coix lachryma-jobi trunk are widely researched especially for diabetes treatment. The optimization of extraction conditions, namely the alcohol concentration, treated herbs and solvent ratio, extraction temperature, and time. The extracts are dried by Labplant machine with two specifications (drying inlet air temperature and flow- rate). Rehmannia glutinosa root is extracted by refluxing method for 60 minutes with 40% alcohol, the ratio of treated herbs and solvent was 1:3, at 800C by three times extract and its dried extract is prepared at a drying inlet air temperature of 90oC, 8 cycles per minute. Coix lachryma-jobi trunk is also extracted by the same method for 60 minutes with 80% alcohol, the ratio of treated herbs and solvent was 1:6, extraction temperature and time are respective 80oC and two times, spray drying conditions were 80oC (drying inlet air temperature) and 4 cycles per minute (flow- rate). The obtained dried extracts of Rehmannia glutinosa root and Coix lachryma-jobi trunk have average moisture contents of 4.52% and 3.84%, respectively. Therefore, this study is a novel approach to significantly decreasing the amount of carriers to reduce research's funds and saving dried extracts' price.


2019 ◽  
Vol 476 (24) ◽  
pp. 3705-3719 ◽  
Author(s):  
Avani Vyas ◽  
Umamaheswar Duvvuri ◽  
Kirill Kiselyov

Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we show a strong positive correlation between mRNA levels of TMEM16A and ATP7B in human SCCHN tumors. TMEM16A overexpression and depletion in SCCHN cell lines caused parallel changes in the ATP7B mRNA levels. The ATP7B increase in TMEM16A-overexpressing cells was reversed by suppression of NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that increased oxidative stress in TMEM16A-overexpressing cells liberates the chelated copper in the cytoplasm, leading to the transcriptional activation of ATP7B expression. This, in turn, decreases the efficacy of platinum compounds by promoting their vesicular sequestration. We think that such a new explanation of the mechanism of SCCHN tumors’ platinum resistance identifies novel approach to treating these tumors.


2020 ◽  
Vol 51 (3) ◽  
pp. 544-560 ◽  
Author(s):  
Kimberly A. Murphy ◽  
Emily A. Diehm

Purpose Morphological interventions promote gains in morphological knowledge and in other oral and written language skills (e.g., phonological awareness, vocabulary, reading, and spelling), yet we have a limited understanding of critical intervention features. In this clinical focus article, we describe a relatively novel approach to teaching morphology that considers its role as the key organizing principle of English orthography. We also present a clinical example of such an intervention delivered during a summer camp at a university speech and hearing clinic. Method Graduate speech-language pathology students provided a 6-week morphology-focused orthographic intervention to children in first through fourth grade ( n = 10) who demonstrated word-level reading and spelling difficulties. The intervention focused children's attention on morphological families, teaching how morphology is interrelated with phonology and etymology in English orthography. Results Comparing pre- and posttest scores, children demonstrated improvement in reading and/or spelling abilities, with the largest gains observed in spelling affixes within polymorphemic words. Children and their caregivers reacted positively to the intervention. Therefore, data from the camp offer preliminary support for teaching morphology within the context of written words, and the intervention appears to be a feasible approach for simultaneously increasing morphological knowledge, reading, and spelling. Conclusion Children with word-level reading and spelling difficulties may benefit from a morphology-focused orthographic intervention, such as the one described here. Research on the approach is warranted, and clinicians are encouraged to explore its possible effectiveness in their practice. Supplemental Material https://doi.org/10.23641/asha.12290687


2015 ◽  
Vol 21 ◽  
pp. 128
Author(s):  
Kaniksha Desai ◽  
Halis Akturk ◽  
Ana Maria Chindris ◽  
Shon Meek ◽  
Robert Smallridge ◽  
...  
Keyword(s):  

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