Rattle-Type Gold Nanorods/Porous-SiO2 Nanocomposites as Near-Infrared Light-Activated Drug Delivery Systems for Cancer Combined Chemo–Photothermal Therapy

2019 ◽  
Vol 16 (5) ◽  
pp. 1929-1938 ◽  
Author(s):  
Yanyan Yu ◽  
Min Zhou ◽  
Wei Zhang ◽  
Lei Huang ◽  
Dandan Miao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Drug Delivery Systems ◽  
Near Infrared ◽  
Delivery Systems ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Porous Sio2 ◽  
Sio2 Nanocomposites

Emerging strategies in near-infrared light triggered drug delivery using organic nanomaterials

2017 ◽  
Vol 5 (8) ◽  
pp. 1491-1499 ◽  
Author(s):  
Ai Lin Chin ◽  
Yongliang Zhong ◽  
Rong Tong
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Near Infrared ◽  
Delivery Systems ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Organic Nanomaterials

Near-infrared light has significant advantages for light-triggered drug delivery systems within deep tissues.

Near-infrared-light responsive nanoscale drug delivery systems for cancer treatment

2016 ◽  
Vol 320-321 ◽  
pp. 100-117 ◽  
Author(s):  
Guangbao Yang ◽  
Jingjing Liu ◽  
Yifan Wu ◽  
Liangzhu Feng ◽  
Zhuang Liu
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Drug Delivery Systems ◽  
Near Infrared ◽  
Delivery Systems ◽  
Infrared Light ◽  
Near Infrared Light

Gold Nanorods Coated with Mesoporous Silica Shell as Drug Delivery System for Remote Near Infrared Light-Activated Release and Potential Phototherapy

Small ◽  
2015 ◽  
Vol 11 (19) ◽  
pp. 2323-2332 ◽  
Author(s):  
Ji Liu ◽  
Christophe Detrembleur ◽  
Marie-Claire De Pauw-Gillet ◽  
Stéphane Mornet ◽  
Christine Jérôme ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery System ◽  
Delivery System ◽  
Gold Nanorods ◽  
Near Infrared ◽  
Silica Shell ◽  
Infrared Light ◽  
Near Infrared Light

scholarly journals Stimuli-Responsive Nanofibers Containing Gold Nanorods for On-Demand Drug Delivery Platforms

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1319
Author(s):  
Baljinder Singh ◽  
Nutan Shukla ◽  
Junkee Kim ◽  
Kibeom Kim ◽  
Myoung-Hwan Park
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Gold Nanorods ◽  
Drug Delivery Systems ◽  
Near Infrared ◽  
Resonance Effect ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
On Demand ◽  
Multiple Drugs

On-demand drug delivery systems using nanofibers have attracted significant attention owing to their controllable properties for drug release through external stimuli. Near-infrared (NIR)-responsive nanofibers provide a platform where the drug release profile can be achieved by the on-demand supply of drugs at a desired dose for cancer therapy. Nanomaterials such as gold nanorods (GNRs) exhibit absorbance in the NIR range, and in response to NIR irradiation, they generate heat as a result of a plasmon resonance effect. In this study, we designed poly (N-isopropylacrylamide) (PNIPAM) composite nanofibers containing GNRs. PNIPAM is a heat-reactive polymer that provides a swelling and deswelling property to the nanofibers. Electrospun nanofibers have a large surface-area-to-volume ratio, which is used to effectively deliver large quantities of drugs. In this platform, both hydrophilic and hydrophobic drugs can be introduced and manipulated. On-demand drug delivery systems were obtained through stimuli-responsive nanofibers containing GNRs and PNIPAM. Upon NIR irradiation, the heat generated by the GNRs ensures shrinking of the nanofibers owing to the thermal response of PNIPAM, thereby resulting in a controlled drug release. The versatility of the light-responsive nanofibers as a drug delivery platform was confirmed in cell studies, indicating the advantages of the swelling and deswelling property of the nanofibers and on–off drug release behavior with good biocompatibility. In addition, the system has potential for the combination of chemotherapy with multiple drugs to enhance the effectiveness of complex cancer treatments.

Gold nanorods@mSiO2 with a smart polymer shell responsive to heat/near-infrared light for chemo-photothermal therapy

2012 ◽  
Vol 22 (31) ◽  
pp. 16095 ◽  
Author(s):  
Hongyan Tang ◽  
Shun Shen ◽  
Jia Guo ◽  
Baisong Chang ◽  
Xinguo Jiang ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Light ◽  
Polymer Shell ◽  
Near Infrared Light ◽  
Smart Polymer
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