Dual-Responsive Dual-Drug-Loaded Bioinspired Polydopamine Nanospheres as an Efficient Therapeutic Nanoplatform against Drug-Resistant Cancer Cells

Conventional cancer chemotherapy is facing difficulties in improving the bioavailability, overcoming the severe adverse side effect of chemotherapeutics and reversing the multidrug resistance of cancer cells. To address these challenges,...

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pH/Redox Dual-Responsive Polyplex with Effective Endosomal Escape for Codelivery of siRNA and Doxorubicin against Drug-Resistant Cancer Cells

ACS Applied Materials & Interfaces ◽

10.1021/acsami.9b02016 ◽

2019 ◽

Vol 11 (18) ◽

pp. 16296-16310 ◽

Cited By ~ 20

Author(s):

Yan Gao ◽

Li Jia ◽

Qi Wang ◽

Haiyang Hu ◽

Xiuli Zhao ◽

...

Keyword(s):

Cancer Cells ◽

Endosomal Escape ◽

Drug Resistant ◽

Dual Responsive

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Knockdown of UbcH10 Enhances the Chemosensitivity of Dual Drug Resistant Breast Cancer Cells to Epirubicin and Docetaxel

International Journal of Molecular Sciences ◽

10.3390/ijms16034698 ◽

2015 ◽

Vol 16 (3) ◽

pp. 4698-4712 ◽

Cited By ~ 15

Author(s):

Cheng Wang ◽

Yun-Hao Pan ◽

Ming Shan ◽

Ming Xu ◽

Jia-Lin Bao ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Breast Cancer Cells ◽

Drug Resistant ◽

Dual Drug

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Soft drug-resistant ovarian cancer cells invade via two distinct mechanisms utilizing myosin IIB

10.1101/099655 ◽

2017 ◽

Author(s):

Aastha Kapoor ◽

Bhushan Thakur ◽

Melissa Monteiro ◽

Alakesh Das ◽

Sejal Desai ◽

...

Keyword(s):

Ovarian Cancer ◽

Cancer Cells ◽

Ovarian Cancer Cells ◽

Drug Resistant ◽

Protease Inhibition ◽

Invasion Mechanisms ◽

Soft Drug ◽

Metalloproteinase 9 ◽

Independent Mode ◽

Dual Drug

The failure of chemotherapeutic drugs in treatment of various cancers is attributed to the acquisition of drug resistance. However, the invasion mechanisms of drug-resistant cancer cells remains incompletely understood. Here we address this question from a biophysical perspective by mapping the phenotypic alterations in ovarian cancer cells (OCCs) resistant to cisplatin and paclitaxel. We show that cisplatin-resistant (CisR), paclitaxel-resistant (PacR) and dual drug-resistant (i.e., resistant to both drugs) OCCs are softer and more contractile than drug-sensitive cells. Protease inhibition suppresses invasion of CisR cells but not of PacR and dual cells, suggesting protease-dependent mode of invasion in CisR cells and protease-independent mode in PacR and dual cells. Despite these differences, actomyosin contractility, mediated by the RhoA-ROCK2-Myosin IIB signaling pathway regulates both modes of invasion. Myosin IIB modulates matrix metalloproteinase-9 (MMP-9) secretion in CisR cells and nuclear squeezing in PacR and dual cells, thereby highlighting its importance as a potential therapeutic target for treatment of drug-resistant ovarian cancer cells.

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Near-infrared light and magnetic field dual-responsive porous silicon-based nanocarriers to overcome multidrug resistance in breast cancer cells with enhanced efficiency

Journal of Materials Chemistry B ◽

10.1039/c9tb02340b ◽

2020 ◽

Vol 8 (3) ◽

pp. 546-557 ◽

Cited By ~ 2

Author(s):

Jiachen Li ◽

Weiwei Zhang ◽

Yan Gao ◽

Haibei Tong ◽

Zhenyu Chen ◽

...

Keyword(s):

Breast Cancer ◽

Magnetic Field ◽

Cancer Cells ◽

Breast Cancer Cells ◽

Near Infrared ◽

Drug Carriers ◽

Infrared Light ◽

Drug Resistant ◽

Dual Responsive ◽

Silicon Based

Magnetic and photothermal PSiNPs@(Fe3O4/Au) nanocomposites as anticancer drug carriers improved combined chemo-photothermal therapeutic efficacy of drug-resistant breast cancer cells.

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