Direct, One-Step Growth of NiSe2 on Cellulose Paper: A Low-Cost, Flexible, and Wearable with Smartphone Enabled Multifunctional Sensing Platform for Customized Noninvasive Personal Healthcare Monitoring

Cross-coupling between substrates that can be easily derived from phenols is highly attractive due to the abundance and low cost of phenols. Here, we report a dual nickel/palladium-catalyzed reductive cross-coupling between aryl tosylates and aryl triflates; both substrates can be accessed in just one step from readily available phenols. The reaction has a broad functional group tolerance and substrate scope (>60 examples). Furthermore, it displays low sensitivity to steric effects demonstrated by the synthesis of a 2,2’disubstituted biaryl and a fully substituted aryl product. The widespread presence of phenols in natural products and pharmaceuticals allow for straightforward late-stage functionalization, illustrated with examples such as Ezetimibe and tyrosine. NMR spectroscopy and DFT calculations indicate that the nickel catalyst is responsible for activating the aryl triflate, while the palladium catalyst preferentially reacts with the aryl tosylate.

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Surface Modification of Poly(Vinylchloride) for Manufacturing Advanced Catheters

Current Medicinal Chemistry ◽

10.2174/0929867327666200227152150 ◽

2020 ◽

Vol 27 (10) ◽

pp. 1616-1633 ◽

Cited By ~ 2

Author(s):

Oana Cristina Duta ◽

Aurel Mihail Ţîţu ◽

Alexandru Marin ◽

Anton Ficai ◽

Denisa Ficai ◽

...

Keyword(s):

Surface Modification ◽

Chemical Modification ◽

Medical Devices ◽

Low Cost ◽

Physical And Mechanical Properties ◽

Polymeric Materials ◽

Modern Medicine ◽

Structural Failure ◽

Chemical Grafting ◽

One Step

Polymeric materials, due to their excellent physicochemical properties and versatility found applicability in multiples areas, including biomaterials used in tissue regeneration, prosthetics (hip, artificial valves), medical devices, controlled drug delivery systems, etc. Medical devices and their applications are very important in modern medicine and the need to develop new materials with improved properties or to improve the existent materials is increasing every day. Numerous reasearches are activated in this domain in order to obtain materials/surfaces that does not have drawbacks such as structural failure, calcifications, infections or thrombosis. One of the most used material is poly(vinylchloride) (PVC) due to its unique properties, availability and low cost. The most common method used for obtaining tubular devices that meet the requirements of medical use is the surface modification of polymers without changing their physical and mechanical properties, in bulk. PVC is a hydrophobic polymer and therefore many research studies were conducted in order to increase the hydrophilicity of the surface by chemical modification in order to improve biocompatibility, to enhance wettability, reduce friction or to make lubricious or antimicrobial coatings. Surface modification of PVC can be achieved by several strategies, in only one step or, in some cases, in two or more steps by applying several techniques consecutively to obtain the desired modification / performances. The most common processes used for modifying the surface of PVC devices are: plasma treatment, corona discharge, chemical grafting, electric discharge, vapour deposition of metals, flame treatment, direct chemical modification (oxidation, hydrolysis, etc.) or even some physical modification of the roughness of the surface.

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Smart Wearable Sensors Based on Triboelectric Nanogenerator for Personal Healthcare Monitoring

Micromachines ◽

10.3390/mi12040352 ◽

2021 ◽

Vol 12 (4) ◽

pp. 352

Author(s):

Ruonan Li ◽

Xuelian Wei ◽

Jiahui Xu ◽

Junhuan Chen ◽

Bin Li ◽

...

Keyword(s):

Medical Care ◽

Health Monitoring ◽

Wearable Sensors ◽

The Elderly ◽

The Body ◽

Assessment System ◽

Triboelectric Nanogenerator ◽

Personal Healthcare ◽

Healthcare Monitoring ◽

Smart Wearable

Accurate monitoring of motion and sleep states is critical for human health assessment, especially for a healthy life, early diagnosis of diseases, and medical care. In this work, a smart wearable sensor (SWS) based on a dual-channel triboelectric nanogenerator was presented for a real-time health monitoring system. The SWS can be worn on wrists, ankles, shoes, or other parts of the body and cloth, converting mechanical triggers into electrical output. By analyzing these signals, the SWS can precisely and constantly monitor and distinguish various motion states, including stepping, walking, running, and jumping. Based on the SWS, a fall-down alarm system and a sleep quality assessment system were constructed to provide personal healthcare monitoring and alert family members or doctors via communication devices. It is important for the healthy growth of the young and special patient groups, as well as for the health monitoring and medical care of the elderly and recovered patients. This work aimed to broaden the paths for remote biological movement status analysis and provide diversified perspectives for true-time and long-term health monitoring, simultaneously.

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One step “growth to spinning” of biaxially multilayered CNT web electrode for long cycling Li-O2 batteries

Carbon ◽

10.1016/j.carbon.2021.06.031 ◽

2021 ◽

Author(s):

Young Shik Cho ◽

Hyunjin Kim ◽

Minhoo Byeon ◽

Yeonsu Jung ◽

DongJoon Lee ◽

...

Keyword(s):

One Step ◽

Step Growth

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T4-like Bacteriophages Isolated from Pig Stools Infect Yersinia pseudotuberculosis and Yersinia pestis Using LPS and OmpF as Receptors

Viruses ◽

10.3390/v13020296 ◽

2021 ◽

Vol 13 (2) ◽

pp. 296

Author(s):

Mabruka Salem ◽

Maria I. Pajunen ◽

Jin Woo Jun ◽

Mikael Skurnik

Keyword(s):

Yersinia Pseudotuberculosis ◽

Host Recognition ◽

Tail Fiber ◽

Long Tail ◽

Phage T4 ◽

One Step ◽

In Trans ◽

Step Growth ◽

Resistant Strains ◽

Salmonella Phage

The Yersinia bacteriophages fPS-2, fPS-65, and fPS-90, isolated from pig stools, have long contractile tails and elongated heads, and they belong to genus Tequatroviruses in the order Caudovirales. The phages exhibited relatively wide host ranges among Yersinia pseudotuberculosis and related species. One-step growth curve experiments revealed that the phages have latent periods of 50–80 min with burst sizes of 44–65 virions per infected cell. The phage genomes consist of circularly permuted dsDNA of 169,060, 167,058, and 167,132 bp in size, respectively, with a G + C content 35.3%. The number of predicted genes range from 267 to 271. The phage genomes are 84–92% identical to each other and ca 85% identical to phage T4. The phage receptors were identified by whole genome sequencing of spontaneous phage-resistant mutants. The phage-resistant strains had mutations in the ompF, galU, hldD, or hldE genes. OmpF is a porin, and the other genes encode lipopolysaccharide (LPS) biosynthetic enzymes. The ompF, galU, and hldE mutants were successfully complemented in trans with respective wild-type genes. The host recognition was assigned to long tail fiber tip protein Gp38, analogous to that of T-even phages such as Salmonella phage S16, specifically to the distal β-helices connecting loops.

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