scholarly journals Platelet Rich Plasma: a short overview of certain bioactive components

Open Medicine ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. 242-247 ◽  
Author(s):  
Voja Pavlovic ◽  
Milan Ciric ◽  
Vladimir Jovanovic ◽  
Predrag Stojanovic
Keyword(s):  
Wound Healing ◽  
Reference Data ◽  
Platelet Rich Plasma ◽  
Physiological Role ◽  
Potential Effect ◽  
Bioactive Components ◽  
Bioactive Substances ◽  
New Approach ◽  
Different Tissues

AbstractPlatelet rich plasma (PRP) represents a relatively new approach in regenerative medicine. It is obtained from patient’s own blood and contains different growth factors and other biomolecules necessary for wound healing. Since there are various protocols for PRP preparing, it usually results with PRP generation with different amounts of bioactive substances, which finally may modulate the intensity of wound healing. The reference data about potential effect of some PRP compounds on wound healing, in different tissues, are still controversial. This review summarizes recently known facts about physiological role of certain PRP components and guidance for further research. Also, this review discusses different procedure for PRP generation and potential effect of leukocytes on wound healing.

scholarly journals Potential therapeutic manipulations of the CXCR3 chemokine axis for the treatment of inflammatory fibrosing diseases

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 1197
Author(s):  
Morgan K. Groover ◽  
Jillian M. Richmond
Keyword(s):  
Wound Healing ◽  
Tumor Metastasis ◽  
Ex Vivo ◽  
Experimental Models ◽  
The Body ◽  
Human Tissues ◽  
Inflammatory Processes ◽  
Opinion Article ◽  
Different Tissues

Chemokines play important roles in homeostasis and inflammatory processes. While their roles in leukocyte recruitment are well-appreciated, chemokines play additional roles in the body, including mediating or regulating angiogenesis, tumor metastasis and wound healing. In this opinion article, we focus on the role of CXCR3 and its ligands in fibrotic processes. We emphasize differences of the effects of each ligand, CXCL9, CXCL10 and CXCL11, on fibroblasts in different tissues of the body. We include discussions of differences in signaling pathways that may account for protective or pro-fibrotic effects of each ligand in different experimental models and ex vivo analysis of human tissues. Our goal is to highlight potential reasons why there are disparate findings in different models, and to suggest ways in which this chemokine axis could be manipulated for the treatment of fibrosis.

Role of Bovine Fetal Platelet-rich Plasma (PRP) on Skin Wound Healing in Mice

2019 ◽  
Vol 16 (1) ◽  
pp. 18-26
Author(s):  
Mardin O. Mohammed ◽  
Osman J. Ali ◽  
Sozan A. Muhamad ◽  
Salam H. Ibrahim ◽  
Goran M. Raouf ◽  
...  
Keyword(s):  
Wound Healing ◽  
Platelet Rich Plasma ◽  
Skin Wound ◽  
Skin Wound Healing

The Role of “Eye Platelet Rich Plasma” (E-Prp) for Wound Healing in Ophthalmology

2012 ◽  
Vol 13 (7) ◽  
pp. 1257-1265 ◽  
Author(s):  
Jorge L. Alio ◽  
Francisco Arnalich-Montiel ◽  
Alejandra E. Rodriguez
Keyword(s):  
Wound Healing ◽  
Platelet Rich Plasma

scholarly journals Comparing the role of subcision suction method with and without the injection of platelet-rich plasma in the treatment of depressed scars

2017 ◽  
Vol 2 (2) ◽  
Author(s):  
Nouran Abd El-Aziz Abou Khedr ◽  
Tarek Mahmoud Hussein ◽  
Ayat Mohamed El-Sayed Abd El-Fatah
Keyword(s):  
Wound Healing ◽  
Platelet Rich Plasma ◽  
Slight Improvement ◽  
Moderate Improvement ◽  
Acne Scars ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
Short Time

<p class="BodyText1">Among wound-healing modalities, platelet-rich plasma (PRP) has been used for wound healing, through the release of multiple growth factors. The platelets mediate wound healing by initiating the clotting pathway and the subsequent matrix remodelisation. The aim of the work was to study the role of injection of platelet-rich plasma in the treatment of scars. This study was conducted on thirty patients who were divided into two groups (A and B). Each group included fifteen patients. The two groups were randomly distributed by using individual sealed envelopes. Group A was subjected to subcision of their acne scars using Nokor needle, followed by suction. Group B patients were subjected to the same treatment but followed by an injection of platelet-rich plasma once per month over three months. In Group A, 6 patients (40%) showed moderate improvement, 5 patients (33.3%) showed slight improvement and 4 patients (26.7%) showed significant improvement. In Group B, 7 patients (46.7%) showed moderate improvement, 5 patients (33.3%) showed marked improvement and 3 patients (20%) showed significant improvement. There was a statistically significant difference on the independent observer’s after-treatment assessment between the groups (P=0.014). In conclusion, subcision suction leads to a persistent improvement of acne scars in a short time, and the coupling with injection of PRP is the most effective in the treatment of depressed facial scars.</p>

scholarly journals Role of platelet-rich plasma in maxillofacial surgery

2021 ◽  
Author(s):  
Sara Ahmed Hifny ◽  
Abdullrahman Saeed Alalharith ◽  
Mutasim Ahmad Idrees ◽  
Mohammed Ahmed Befle ◽  
Shihnaz Mohammed AlGarni ◽  
...  
Keyword(s):  
Wound Healing ◽  
Oral Surgery ◽  
Platelet Rich Plasma ◽  
Maxillofacial Surgery ◽  
Neck Surgery ◽  
Medical Settings ◽  
Osseointegrated Implants ◽  
Literature Evidence ◽  
Periodontal Plastic Surgery

Platelet-rich plasma (PRP) has been reported as an efficacious modality that can enhance the process of wound healing and tissue regeneration and has been validated in different medical settings, including cardiovascular surgery, otolaryngology, head and neck surgery, and maxillofacial surgery. In dental and oral surgery settings, PRP has been reported as an efficacious approach with favorable outcomes in different settings. Some of these procedures include surgical repair of the alveolar cleft, mandibular reconstruction, ablative surgical procedures, placement of osseointegrated implants, periodontal plastic surgery, and management of infrabony periodontal defects. In the present study, we aim to discuss the role and mechanisms that PRP plays in the settings of maxillofacial surgery based on evidence from the relevant studies in the literature. Evidence indicates the wide acceptance of the modality, which has been proven to increase the rate of wound healing and reduce the frequency of pain and swelling. The administration of PRP has been reported to dispense with the need for invasive approaches that might be furtherly associated with complications and different morbidities. However, in most of the favorable events where the PRP administration of was associated with enhanced outcomes, the modality was used in combination with another therapeutic approach. Therefore, further research is needed to validate the efficacy of the modality in the different settings.

The role of platelet-rich plasma gel combined with chitosan in promoting wound healing

2022 ◽  
Author(s):  
Erchang XU ◽  
Liwen ZHANG ◽  
Chao TIAN ◽  
Lanfang ZHANG ◽  
Qian BAI ◽  
...  
Keyword(s):  
Wound Healing ◽  
Platelet Rich Plasma

Impairment of Phosphatidylinositol Metabolism in a Patient with a Bleeding Disorder Associated with Defects of Initial Platelet Responses

1988 ◽  
Vol 59 (02) ◽  
pp. 175-179 ◽  
Author(s):  
Bruce Lages ◽  
Harvey J Weiss
Keyword(s):  
Phosphatidic Acid ◽  
Platelet Rich Plasma ◽  
Physiological Role ◽  
Bleeding Disorder ◽  
Phosphoinositide Metabolism ◽  
Phosphatidylinositol Metabolism ◽  
Early Activation ◽  
Activation Mechanisms ◽  
Functional Defects

SummaryPhosphoinositide/polyphosphoinositide (PI/PPI) metabolism, measured by the increase of 3H-phosphatidic acid (PA) and the decrease of 3H-phosphatidylinositol (PI) in 3H-arachidonate- labeled platelet suspensions, was assessed in five patients whose platelet functional defects included impaired initial rates of ADP, epinephrine and U44069 aggregation in platelet-rich plasma (PRP). In one patient, 3H-PA formation induced by collagen and thrombin was reduced or absent on two of three occasions, and the decrease in 3H-PI was reduced on one of these two occasions in response to collagen and A23187, and on all 3 occasions in response to thrombin. The variations in the formation of 3H-PA in this patient on different occasions broadly paralleled the variations in the initial rates of ADP and U44069 aggregation and in epinephrine aggregation seen in PRP. No such abnormalities of PI metabolism were found in four other patients with similar, but not identical, functional defects. These results suggest an impairment affecting metabolism of PI/PPI via the PI/PPI cycle in this patient's platelets. The association of abnormalities of PI metabolism with defects of initial platelet responses provides further support for a physiological role of phosphoinositide metabolism in the early activation mechanisms of platelets.

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