Biomimetic Nucleation of Metal–Organic Frameworks on Silk Fibroin Nanoparticles for Designing Core–Shell-Structured pH-Responsive Anticancer Drug Carriers

2021 ◽  
Author(s):  
Yuping Chen ◽  
Hesong Wu ◽  
Tao Yang ◽  
Guanshan Zhou ◽  
Yuyin Chen ◽  
...  
Keyword(s):  
Silk Fibroin ◽  
Anticancer Drug ◽  
Metal Organic Frameworks ◽  
Drug Carriers ◽  
Core Shell ◽  
Ph Responsive ◽  
Silk Fibroin Nanoparticles ◽  
Metal Organic

Computational investigation of metal organic frameworks for storage and delivery of anticancer drugs

2017 ◽  
Vol 5 (35) ◽  
pp. 7342-7351 ◽  
Author(s):  
Ilknur Erucar ◽  
Seda Keskin
Keyword(s):  
Anticancer Drugs ◽  
Anticancer Drug ◽  
Metal Organic Frameworks ◽  
Drug Carriers ◽  
Computational Investigation ◽  
Drug Molecules ◽  
Metal Organic

The potential of metal organic frameworks (MOFs) as binary drug carriers was computationally investigated for storage and delivery of two anticancer drug molecules, methotrexate (MTX) and 5-fluorouracil (5-FU).

Fabrication and application of copper metal–organic frameworks as nanocarriers for pH-responsive anticancer drug delivery

2022 ◽  
Author(s):  
Zahra Gharehdaghi ◽  
Rahmatollah Rahimi ◽  
Seyed Morteza Naghib ◽  
Fatemeh Molaabasi
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Metal Organic Frameworks ◽  
Ph Responsive ◽  
Copper Metal ◽  
Anticancer Drug Delivery ◽  
Metal Organic

scholarly journals Biocompatible Fe-Based Micropore Metal-Organic Frameworks as Sustained-Release Anticancer Drug Carriers

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2490 ◽  
Author(s):  
Xin Leng ◽  
Xiaoxv Dong ◽  
Wenping Wang ◽  
Na Sai ◽  
Chunjing Yang ◽  
...  
Keyword(s):  
Sustained Release ◽  
Anticancer Drug ◽  
High Performance ◽  
Hot Spot ◽  
Metal Organic Frameworks ◽  
Annexin V ◽  
Drug Carriers ◽  
Design And Synthesis ◽  
Metal Organic

Sustained-release preparation is a hot spot in antitumor drug research, where the first task is to select suitable drug carriers. Research has revealed that carboxylic acid iron metal–organic frameworks (MOFs), constructed from iron (Fe) ions and terephthalic acid, are nontoxic and biocompatible. Due to the breathing effect, the skeleton of this mesoporous material is flexible and can reversibly adapt its pore size through drug adsorption. Therefore, we chose one kind of Fe-MOF, MIL-53(Fe), as a carrier for the anticancer drug oridonin (Ori). In this work, we report the design and synthesis of MIL-53(Fe) and explore its ability as a transport vehicle to deliver Ori. MIL-53(Fe) is characterized by scanning electron microscopy and X-ray powder diffraction. A loading capacity of 56.25 wt % was measured by high performance liquid chromatography. This carrier was safe and nontoxic (cell viability > 95.27%), depending on the results of 3-(4,5-dimethylthiazol-2-yl)--2,5-diphenyltetrazolium bromide assays, lactate dehydrogenase assays, and Annexin V-fluoresce isothiocyanate/propidium iodide double-staining assays. After loading the drug, the structure of the MIL-53(Fe) was not destroyed, and Ori was amorphous in MIL-53(Fe). Based on an analysis of the Ori release profile, results suggest that it lasts for more than seven days in vitro. The cumulative release rate of Ori at the seventh day was about 82.23% and 91.75% in phosphate buffer saline solution at 37 °C under pH 7.2 and pH 5.5, respectively. HepG2 cells were chosen to study the cytotoxicity of Ori@MIL-53(Fe), and the results show that the anticancer ratio of Ori@MIL-53(Fe) system reaches 90.62%. Thus, MIL-53 can be used as a carrier for anticancer drugs and Ori@MIL-53(Fe) is a promising sustained-release drug delivery system for the cancer therapy.

Tuning and understanding the electronic effect of Co-Mo-O sties in bifunctional electrocatalysts for ultralong-lasting rechargable zinc-air battery

2021 ◽  
Author(s):  
Yi Guan ◽  
Nan Li ◽  
Jiao He ◽  
Yongliang Li ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Electronic Effect ◽  
Metal Organic Frameworks ◽  
Core Shell ◽  
Zeolitic Imidazolate Frameworks ◽  
Assembly Strategy ◽  
The Core ◽  
Bifunctional Electrocatalysts ◽  
Metal Organic ◽  
Air Battery

Herein, we report a post-assembly strategy by growing the bimetallic Co/Zn zeolitic imidazolate frameworks (BIMZIF) on the surface of the customized Mo metal-organic frameworks (MOFs) (Mo-MOF) to prepare the core-shell...

Core-shell ZIF-8@polydopamine nanoparticles obtained by mitigating polydopamine coating induced self-etching of MOFs: prototypical metal ion reservoirs for sticking to and killing bacteria

2021 ◽  
Author(s):  
Yingxue Tu ◽  
Caifen Lei ◽  
Fei Deng ◽  
Yiang Chen ◽  
Ying Wang ◽  
...  
Keyword(s):  
Metal Ions ◽  
Metal Ion ◽  
Biomedical Applications ◽  
Metal Organic Frameworks ◽  
Core Shell ◽  
Metal Organic

Metal organic frameworks (MOFs) have the potential to boost the undervalued biomedical applications of metal ions. Such endeavor has been hindered by the challenge of how to avoid the (cyto)toxicity...

Metal-Organic Frameworks-Derived CoMOF-D@Si@C Core-Shell Structure for High-Performance Lithium-Ion Battery Anode

2021 ◽  
pp. 138814
Author(s):  
Zhilin Yan ◽  
Jiyang Liu ◽  
Yangfan Lin ◽  
Zheng Deng ◽  
Xueqin He ◽  
...  
Keyword(s):  
Lithium Ion Battery ◽  
Shell Structure ◽  
High Performance ◽  
Metal Organic Frameworks ◽  
Lithium Ion ◽  
Core Shell ◽  
Metal Organic ◽  
Core Shell Structure ◽  
Battery Anode

Computational investigation of metal organic frameworks as potential drug carriers for antihypertensive amlodipine

AIChE Journal ◽  
2021 ◽  
Author(s):  
Jiaqi Liu ◽  
Zhen Yang ◽  
Yuanyuan Che ◽  
Yaojie Zhang ◽  
Zhihao Zhang ◽  
...  
Keyword(s):  
Metal Organic Frameworks ◽  
Drug Carriers ◽  
Potential Drug ◽  
Computational Investigation ◽  
Metal Organic

Screening of bio-compatible metal–organic frameworks as potential drug carriers using Monte Carlo simulations

2014 ◽  
Vol 2 (7) ◽  
pp. 766-774 ◽  
Author(s):  
María C. Bernini ◽  
David Fairen-Jimenez ◽  
Marcelo Pasinetti ◽  
Antonio J. Ramirez-Pastor ◽  
Randall Q. Snurr
Keyword(s):  
Monte Carlo ◽  
Monte Carlo Simulations ◽  
Metal Organic Frameworks ◽  
Drug Carriers ◽  
Potential Drug ◽  
Metal Organic

Atomic Co-N4 and Co nanoparticles confined in COF@ZIF-67 derived core-shell carbon frameworks: Bifunctional non-precious metal catalysts toward ORR and HER

2021 ◽  
Author(s):  
Qing Xu ◽  
Minghao Liu ◽  
Qiyang Miao ◽  
Shuai Yang ◽  
Ping Wu ◽  
...  
Keyword(s):  
Precious Metal ◽  
Metal Organic Frameworks ◽  
Metal Catalysts ◽  
Core Shell ◽  
Covalent Organic Frameworks ◽  
Precious Metal Catalysts ◽  
Metal Organic ◽  
Co Nanoparticles

Constructing heterostructures of covalent organic frameworks (COFs) and metal organic frameworks (MOFs) have gained great attention for various applications due to their well-defined skeletons, ordered porosity and designable functions. Herein,...

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