scholarly journals Biocompatible Fe-Based Micropore Metal-Organic Frameworks as Sustained-Release Anticancer Drug Carriers

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2490 ◽  
Author(s):  
Xin Leng ◽  
Xiaoxv Dong ◽  
Wenping Wang ◽  
Na Sai ◽  
Chunjing Yang ◽  
...  
Keyword(s):  
Sustained Release ◽  
Anticancer Drug ◽  
High Performance ◽  
Hot Spot ◽  
Metal Organic Frameworks ◽  
Annexin V ◽  
Drug Carriers ◽  
Design And Synthesis ◽  
Metal Organic

Sustained-release preparation is a hot spot in antitumor drug research, where the first task is to select suitable drug carriers. Research has revealed that carboxylic acid iron metal–organic frameworks (MOFs), constructed from iron (Fe) ions and terephthalic acid, are nontoxic and biocompatible. Due to the breathing effect, the skeleton of this mesoporous material is flexible and can reversibly adapt its pore size through drug adsorption. Therefore, we chose one kind of Fe-MOF, MIL-53(Fe), as a carrier for the anticancer drug oridonin (Ori). In this work, we report the design and synthesis of MIL-53(Fe) and explore its ability as a transport vehicle to deliver Ori. MIL-53(Fe) is characterized by scanning electron microscopy and X-ray powder diffraction. A loading capacity of 56.25 wt % was measured by high performance liquid chromatography. This carrier was safe and nontoxic (cell viability > 95.27%), depending on the results of 3-(4,5-dimethylthiazol-2-yl)--2,5-diphenyltetrazolium bromide assays, lactate dehydrogenase assays, and Annexin V-fluoresce isothiocyanate/propidium iodide double-staining assays. After loading the drug, the structure of the MIL-53(Fe) was not destroyed, and Ori was amorphous in MIL-53(Fe). Based on an analysis of the Ori release profile, results suggest that it lasts for more than seven days in vitro. The cumulative release rate of Ori at the seventh day was about 82.23% and 91.75% in phosphate buffer saline solution at 37 °C under pH 7.2 and pH 5.5, respectively. HepG2 cells were chosen to study the cytotoxicity of Ori@MIL-53(Fe), and the results show that the anticancer ratio of Ori@MIL-53(Fe) system reaches 90.62%. Thus, MIL-53 can be used as a carrier for anticancer drugs and Ori@MIL-53(Fe) is a promising sustained-release drug delivery system for the cancer therapy.

Insights into binding manners of a Fe doping MOF-808 in high-performance adsorption: A case of antimony adsorption

2021 ◽  
Author(s):  
Baihe Sun ◽  
Kai Zhang ◽  
Zhong Ren ◽  
Chenquan Ni ◽  
Huiqin Hu ◽  
...  
Keyword(s):  
Environmental Remediation ◽  
High Performance ◽  
Hot Spot ◽  
Metal Organic Frameworks ◽  
Fe Doping ◽  
Adsorption Sites ◽  
Adsorption Technology ◽  
Metal Organic ◽  
Full Utilization

The full utilization of adsorption sites is crucial for adsorption technology. Metal-organic frameworks (MOFs), which are hot spot materials in environmental remediation, are not satisfied in many cases for their...

Computational investigation of metal organic frameworks for storage and delivery of anticancer drugs

2017 ◽  
Vol 5 (35) ◽  
pp. 7342-7351 ◽  
Author(s):  
Ilknur Erucar ◽  
Seda Keskin
Keyword(s):  
Anticancer Drugs ◽  
Anticancer Drug ◽  
Metal Organic Frameworks ◽  
Drug Carriers ◽  
Computational Investigation ◽  
Drug Molecules ◽  
Metal Organic

The potential of metal organic frameworks (MOFs) as binary drug carriers was computationally investigated for storage and delivery of two anticancer drug molecules, methotrexate (MTX) and 5-fluorouracil (5-FU).

Facile Ultrasound-Triggered Release of Calcein and Doxorubicin from Iron-Based Metal-Organic Frameworks

2020 ◽  
Vol 16 (9) ◽  
pp. 1359-1369
Author(s):  
Mihad Ibrahim ◽  
Rana Sabouni ◽  
Ghaleb A. Husseini ◽  
Abdollah Karami ◽  
Reenu Geetha Bai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Encapsulation Efficiency ◽  
Metal Organic Frameworks ◽  
In Vitro Release ◽  
Triggered Release ◽  
Anticancer Drug Delivery ◽  
Metal Organic ◽  
Iron Based

Metal-organic frameworks (MOFs) are promising new nanocarriers with potential use in anticancer drug delivery. However, there is a scarcity of studies on the uptake and release of guest molecules associated with MOF nanovehicles, and their mechanism is poorly understood. In this work, newly developed iron-based MOFs, namely Fe-NDC nanorods, were investigated as potential nanocarriers for calcein (as a model drug/dye) and Doxorubicin (a chemotherapeutic drug (DOX)). Calcein was successfully loaded by equilibrating its solution with the MOFs nanoparticles under constant stirring. The calcein average encapsulation efficiency achieved was 43.13%, with a corresponding capacity of 17.74 wt.%. In-vitro calcein release was then carried out at 37°C in phosphate buffer saline (PBS) using ultrasound (US) as an external trigger. MOFs released an average of 17.8% (without US), whereas they released up to 95.2% of their contents when 40-kHz US at ~1 W/cm2 was applied for 10 min. The Cytotoxic drug DOX was also encapsulated in Fe-NDC, and its In-vitro release profile was determined under the same conditions. DOX encapsulation efficiency and capacity were found to be 16.10% and 13.37 wt.%, respectively. In-vitro release experiments demonstrated significant release, reaching 80% in 245 minutes, under acoustic irradiation, compared to around 6% in the absence of US. Additionally, experimental results showed that Fe-NDC nanoparticles are biocompatible even at relatively high concentrations, with an MCF-7 IC50 of 1022 g/ml. Our work provides a promising platform for anticancer drug delivery by utilizing biocompatible Fe-NDC nanoparticles and US as an external trigger mechanism.

Design and Synthesis of Conductive Metal‐Organic Frameworks and Their Composites for Supercapacitors

2021 ◽  
Author(s):  
Ting Yue ◽  
Chenfeng Xia ◽  
Xiaobang Liu ◽  
Zhitong Wang ◽  
Kai Qi ◽  
...  
Keyword(s):  
Metal Organic Frameworks ◽  
Design And Synthesis ◽  
Metal Organic

Rational strategies for proton-conductive metal–organic frameworks

2021 ◽  
Author(s):  
Dae-Woon Lim ◽  
Hiroshi Kitagawa
Keyword(s):  
Solid State ◽  
Potential Application ◽  
High Performance ◽  
Metal Organic Frameworks ◽  
Metal Organic ◽  
Solid State Electrolytes

Since the transition of energy platforms, the proton-conductive metal–organic frameworks (MOFs) exhibiting high performance have been extensively investigated with rational strategies for their potential application in solid-state electrolytes.

Recent progress in the design and synthesis of zeolite-like metal–organic frameworks (ZMOFs)

2021 ◽  
Author(s):  
Xinyao Liu ◽  
Yunling Liu
Keyword(s):  
Building Block ◽  
High Stability ◽  
Recent Progress ◽  
Metal Organic Frameworks ◽  
Excellent Performance ◽  
Design And Synthesis ◽  
Molecular Building Block ◽  
Secondary Building Units ◽  
Metal Organic

ZMOFs are a subset of MOFs that exhibit zeolite-like topologies. Using molecular building block strategy, many ZMOFs with high stability and excellent performance can be rationally designed and synthesized using different secondary building units.

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