Tumor-Homing Cell-Penetrating Peptide Linked to Colloidal Mesoporous Silica Encapsulated (-)-Epigallocatechin-3-gallate as Drug Delivery System for Breast Cancer Therapy in Vivo

2015 ◽  
Vol 7 (32) ◽  
pp. 18145-18155 ◽  
Author(s):  
Jie Ding ◽  
Jing Yao ◽  
Jingjing Xue ◽  
Rong Li ◽  
Bo Bao ◽  
...  
2018 ◽  
Vol 51 (5) ◽  
pp. e12488 ◽  
Author(s):  
Tingting Kong ◽  
Liying Hao ◽  
Yuanyuan Wei ◽  
Xiaoxiao Cai ◽  
Bofeng Zhu

2021 ◽  
Vol 133 ◽  
pp. 111053
Author(s):  
Dorota Bartusik-Aebisher ◽  
Grzegorz Chrzanowski ◽  
Zuzanna Bober ◽  
David Aebisher

2020 ◽  
Vol 27 (15) ◽  
pp. 2494-2513 ◽  
Author(s):  
João A. Oshiro-Júnior ◽  
Camila Rodero ◽  
Gilmar Hanck-Silva ◽  
Mariana R. Sato ◽  
Renata Carolina Alves ◽  
...  

Stimuli-responsive drug-delivery nanocarriers (DDNs) have been increasingly reported in the literature as an alternative for breast cancer therapy. Stimuli-responsive DDNs are developed with materials that present a drastic change in response to intrinsic/chemical stimuli (pH, redox and enzyme) and extrinsic/physical stimuli (ultrasound, Near-infrared (NIR) light, magnetic field and electric current). In addition, they can be developed using different strategies, such as functionalization with signaling molecules, leading to several advantages, such as (a) improved pharmaceutical properties of liposoluble drugs, (b) selectivity with the tumor tissue decreasing systemic toxic effects, (c) controlled release upon different stimuli, which are all fundamental to improving the therapeutic effectiveness of breast cancer treatment. Therefore, this review summarizes the use of stimuli-responsive DDNs in the treatment of breast cancer. We have divided the discussions into intrinsic and extrinsic stimuli and have separately detailed them regarding their definitions and applications. Finally, we aim to address the ability of these stimuli-responsive DDNs to control the drug release in vitro and the influence on breast cancer therapy, evaluated in vivo in breast cancer models.


2016 ◽  
Vol 4 (21) ◽  
pp. 3760-3769 ◽  
Author(s):  
Ning Li ◽  
Chunhua Guo ◽  
Zhenyu Duan ◽  
Lingzhu Yu ◽  
Kui Luo ◽  
...  

A Janus mPEGylated dendron–PVGLIG–DOX conjugate self-assembled into nanoparticles was employed as a matrix metalloproteinase-2/9 enzyme-sensitive and safe nanoscale drug delivery system for breast cancer therapy.


2014 ◽  
Vol 6 (9) ◽  
pp. 6469-6480 ◽  
Author(s):  
Raju Vivek ◽  
Ramar Thangam ◽  
Varukattu NipunBabu ◽  
Chandrababu Rejeeth ◽  
Srinivasan Sivasubramanian ◽  
...  

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