MR/SPECT Imaging Guided Photothermal Therapy of Tumor-Targeting Fe@Fe3O4 Nanoparticles in Vivo with Low Mononuclear Phagocyte Uptake

A novel NIR-II probe QT-RGD consisting of a NIR-II fluorophore and two tumor-targeting cyclic-RGD peptides was reported. In vitro and in vivo studies show that it could be successfully used for multimodal NIR-II/PA/SPECT imaging and photothermal therapy of malignant tumor.

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Multi-layered tumor-targeting photothermal-doxorubicin releasing nanotubes eradicate tumors in vivo with negligible systemic toxicity

Nanoscale ◽

10.1039/c8nr00663f ◽

2018 ◽

Vol 10 (18) ◽

pp. 8536-8546 ◽

Cited By ~ 16

Author(s):

Daquan Wang ◽

Lingjie Meng ◽

Zhaofu Fei ◽

Chen Hou ◽

Jiangang Long ◽

...

Keyword(s):

Carbon Nanotubes ◽

Photothermal Therapy ◽

Tumor Targeting ◽

Single Walled Carbon Nanotubes ◽

Layer By Layer ◽

Assembly Process ◽

Small Molecule Drug ◽

Walled Carbon Nanotubes ◽

Layer Assembly

Multi-layered single-walled carbon nanotubes, termed SWNT@BSA@Au-S-PEG-FA@DOX, which integrate photothermal therapy with small molecule drug delivery, were prepared using a facile layer-by-layer assembly process.

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RGD-Conjugated Dendrimer-Modified Gold Nanorods for in Vivo Tumor Targeting and Photothermal Therapy

Molecular Pharmaceutics ◽

10.1021/mp9001415 ◽

2009 ◽

Vol 7 (1) ◽

pp. 94-104 ◽

Cited By ~ 221

Author(s):

Zhiming Li ◽

Peng Huang ◽

Xuejun Zhang ◽

Jing Lin ◽

Sen Yang ◽

...

Keyword(s):

Gold Nanorods ◽

Photothermal Therapy ◽

Tumor Targeting

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The synergistic effect of folate and RGD dual ligand of nanographene oxide on tumor targeting and photothermal therapy in vivo

Nanoscale ◽

10.1039/c5nr05067g ◽

2015 ◽

Vol 7 (44) ◽

pp. 18584-18594 ◽

Cited By ~ 48

Author(s):

Cheol Jang ◽

Jong Hyun Lee ◽

Abhishek Sahu ◽

Giyoong Tae

Keyword(s):

Synergistic Effect ◽

Photothermal Therapy ◽

Tumor Targeting

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In vivo Imaging-Guided Nanoplatform for Tumor Targeting Delivery and Combined Chemo-, Gene- and Photothermal Therapy

Theranostics ◽

10.7150/thno.28241 ◽

2018 ◽

Vol 8 (20) ◽

pp. 5662-5675 ◽

Cited By ~ 18

Author(s):

Cheng Li ◽

Xiao-Quan Yang ◽

Ming-Zhen Zhang ◽

Yuan-Yang Song ◽

Kai Cheng ◽

...

Keyword(s):

In Vivo Imaging ◽

Photothermal Therapy ◽

Tumor Targeting ◽

Targeting Delivery

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Development of theranostic dual-layered Au-liposome for effective tumor targeting and photothermal therapy

Journal of Nanobiotechnology ◽

10.1186/s12951-021-01010-3 ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Miyeon Jeon ◽

Gaeun Kim ◽

Wooseung Lee ◽

Seungki Baek ◽

Han Na Jung ◽

...

Keyword(s):

In Vivo Imaging ◽

Photothermal Therapy ◽

Tumor Targeting ◽

Therapeutic Strategy ◽

Tumor Growth Inhibition ◽

Positron Emission ◽

Anti Cancer ◽

Good Biocompatibility ◽

Targeting Ability

Abstract Background Photothermal therapy (PTT) is an emerging anti-cancer therapeutic strategy that generates hyperthermia to ablate cancer cells under laser irradiation. Gold (Au) coated liposome (AL) was reported as an effective PTT agent with good biocompatibility and excretory property. However, exposed Au components on liposomes can cause instability in vivo and difficulty in further functionalization. Results Herein, we developed a theranostic dual-layered nanomaterial by adding liposomal layer to AL (LAL), followed by attaching polyethylene glycol (PEG) and radiolabeling. Functionalization with PEG improves the in vivo stability of LAL, and radioisotope labeling enables in vivo imaging of LAL. Functionalized LAL is stable in physiological conditions, and 64Cu labeled LAL (64Cu-LAL) shows a sufficient blood circulation property and an effective tumor targeting ability of 16.4%ID g−1 from in vivo positron emission tomography (PET) imaging. Also, intravenously injected LAL shows higher tumor targeting, temperature elevation in vivo, and better PTT effect in orthotopic breast cancer mouse model compared to AL. The tumor growth inhibition rate of LAL was 3.9-fold higher than AL. Conclusion Based on these high stability, in vivo imaging ability, and tumor targeting efficiency, LAL could be a promising theranostic PTT agent. Graphic Abstract

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Destruction of Fibroadenomas Using Photothermal Heating of Fe3O4 Nanoparticles: Experiments and Models

Applied Sciences ◽

10.3390/app10175844 ◽

2020 ◽

Vol 10 (17) ◽

pp. 5844 ◽

Cited By ~ 1

Author(s):

Ivan B. Yeboah ◽

Selassie Wonder King Hatekah ◽

Yvonne Kafui Konku-Asase ◽

Abu Yaya ◽

Kwabena Kan-Dapaah

Keyword(s):

Fe3o4 Nanoparticles ◽

Breast Imaging ◽

Photothermal Therapy ◽

Near Infrared ◽

Integrated Approach ◽

Mie Scattering ◽

Optical Absorption Coefficient ◽

Benign Tumors ◽

Patient Anxiety

Conventionally, observation (yearly breast imaging) is preferred to therapy to manage small-sized fibroadenomas because they are normally benign tumors. However, recent reports of increased cancer risk coupled with patient anxiety due to fear of malignancy motivate the need for non-aggressive interventions with minimal side-effects to destroy such tumors. Here, we describe an integrated approach composed of experiments and models for photothermal therapy for fibroadenomas destruction. We characterized the optical and structural properties and quantified the heat generation performance of Fe3O4 nanoparticles (NPs) by experiments. On the basis of the optical and structural results, we obtained the optical absorption coefficient of the Fe3O4 NPs via predictions based on the Mie scattering theory and integrated it into a computational model to predict in-vivo thermal damage profiles of NP-embedded fibroadenomas located within a multi-tissue breast model and irradiated with near-infrared 810 nm laser. In a series of temperature-controlled parametric studies, we demonstrate the feasibility of NP-mediated photothermal therapy for the destruction of small fibroadenomas and the influence of tumor size on the selection of parameters such as NP concentration, treatment duration and irradiation protocols (treatment durations and laser power). The implications of the results are then discussed for the development of an integrated strategy for a noninvasive photothermal therapy for fibroadenomas.

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Biomimetic Upconversion Nanoparticles and Gold Nanoparticles for Novel Simultaneous Dual-Modal Imaging-Guided Photothermal Therapy of Cancer

Cancers ◽

10.3390/cancers12113136 ◽

2020 ◽

Vol 12 (11) ◽

pp. 3136 ◽

Cited By ~ 1

Author(s):

Ruliang Wang ◽

Han Yang ◽

Rongxin Fu ◽

Ya Su ◽

Xue Lin ◽

...

Keyword(s):

Cell Membrane ◽

Cancer Cell ◽

Photothermal Therapy ◽

Tumor Targeting ◽

Imaging System ◽

Imaging Systems ◽

Coated Nanoparticles ◽

Cancer Theranostics

Multimodal imaging-guided near-infrared (NIR) photothermal therapy (PTT) is an interesting and promising cancer theranostic method. However, most of the multimodal imaging systems provide structural and functional information used for imaging guidance separately by directly combining independent imaging systems with different detectors, and many problems arise when trying to fuse different modal images that are serially taken by inviting extra markers or image fusion algorithms. Further, most imaging and therapeutic agents passively target tumors through the enhanced permeability and retention (EPR) effect, which leads to low utilization efficiency. To address these problems and systematically improve the performance of the imaging-guided PTT methodology, we report a novel simultaneous dual-modal imaging system combined with cancer cell membrane-coated nanoparticles as a platform for PTT-based cancer theranostics. A novel detector with the ability to detect both high-energy X-ray and low-energy visible light at the same time, as well as a dual-modal imaging system based on the detector, was developed for simultaneous dual-modal imaging. Cancer cell membrane-coated upconversion nanoparticles (CC-UCNPs) and gold nanoparticles (CC-AuNPs) with the capacity for immune evasion and active tumor targeting were engineered for highly specific imaging and high-efficiency PTT therapy. In vitro and in vivo evaluation of macrophage escape and active homologous tumor targeting were performed. Cancer cell membrane-coated nanoparticles (CC-NPs) displayed excellent immune evasion ability, longer blood circulation time, and higher tumor targeting specificity compared to normal PEGylated nanoparticles, which led to highly specific upconversion luminescence (UCL) imaging and PTT-based anti-tumor efficacy. The anti-cancer efficacy of the dual-modal imaging-guided PTT was also evaluated both in vitro and in vivo. Dual-modal imaging yielded precise anatomical and functional information for the PTT process, and complete tumor ablation was achieved with CC-AuNPs. Our biomimetic UCNP/AuNP and novel simultaneous dual-modal imaging combination could be a promising platform and methodology for cancer theranostics.

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AIE nanoparticles camouflaged with tumor cell-derived exosomes for NIR-II imaging-guided photothermal therapy

10.1101/2021.04.19.440457 ◽

2021 ◽

Author(s):

Yirun Li ◽

Xiaoxiao Fan ◽

Yuanyuan Li ◽

Runze Chen ◽

Huwei Ni ◽

...

Keyword(s):

Tumor Cell ◽

Photothermal Therapy ◽

Tumor Targeting ◽

Near Infrared ◽

Specific Targeting ◽

Specific Tumor ◽

Targeting Ability ◽

Targeting Strategy

Nanoparticles (NPs) assisted photothermal therapy (PTT) is a promising cancer treatment modality and has attracted the attention of the scientific mainstream. However, developing NPs that exhibit efficient optical properties and specific tumor targeting capability simultaneously is difficult. Herein, we develop hybrid nanovesicles consisting of tumor cell-derived exosomes (EXO) and organic aggregation-induced emission (AIE) nanoparticles (TT3-oCB NP@EXOs) with enhanced second near-infrared (NIR-II, 900-1700 nm) fluorescence property and PTT functionality. Compared with TT3-oCB NPs, TT3-oCB NP@EXOs exhibit excellent biocompatibility, specific targeting ability in vitro, homing to homologous tumors in vivo, and prolonged circulation time. Furthermore, TT3-oCB NP@EXOs were utilized as biomimetic NPs for NIR-II fluorescence imaging-guided PTT of tumors, due to their high and stable photothermal conversion capacity under 808 nm irradiation. Therefore, the tumor cell-derived EXO/AIE NP hybrid nanovesicles may provide an alternative artificial targeting strategy for improving tumor diagnosis and PTT.

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