scholarly journals Rational Design of Monodisperse Mesoporous Silica Nanoparticles for Phytase Immobilization

ACS Omega ◽  
2020 ◽  
Vol 5 (46) ◽  
pp. 30237-30242
Author(s):  
Chunling Xin ◽  
Xia Wang ◽  
LiLi Liu ◽  
Jinmei Yang ◽  
Suqing Wang ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Rational Design ◽  
Mesoporous Silica Nanoparticles

The rational design of NAMI-A-loaded mesoporous silica nanoparticles as antiangiogenic nanosystems

2015 ◽  
Vol 3 (30) ◽  
pp. 6338-6346 ◽  
Author(s):  
Hao Hu ◽  
Yuanyuan You ◽  
Lizhen He ◽  
Tianfeng Chen
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anticancer Drugs ◽  
Rational Design ◽  
Mesoporous Silica Nanoparticles ◽  
Antiangiogenic Activity

Herein we demonstrate the use of RGD-modified MSNs as a vehicle for anticancer drugs to achieve enhanced antiangiogenic activity.

scholarly journals Preparation and Study of the Antibacterial Applications and Oxidative Stress Induction of Copper Maleamate-Functionalized Mesoporous Silica Nanoparticles

Pharmaceutics ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 30 ◽  
Author(s):  
Diana Díaz-García ◽  
Perla Ardiles ◽  
Sanjiv Prashar ◽  
Antonio Rodríguez-Diéguez ◽  
Paulina Páez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Catalytic Oxidation ◽  
Rational Design ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carriers ◽  
Stress Generation ◽  
Bacterial Cells ◽  
Oxidation Activity

Mesoporous silica nanoparticles (MSNs) are an interesting class of nanomaterials with potential applications in different therapeutic areas and that have been extensively used as drug carriers in different fields of medicine. The present work is focused on the synthesis of MSNs containing a maleamato ligand (MSN-maleamic) and the subsequent coordination of copper(II) ions (MSN-maleamic-Cu) for the exploration of their potential application as antibacterial agents. The Cu-containing nanomaterials have been characterized by different techniques and the preliminary antibacterial effect of the supported maleamato-copper(II) complexes has been tested against two types of bacteria (Gram positive and Gram negative) in different assays to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The biological results showed a moderate antibacterial activity against Escherichia coli which motivated a more detailed study of the antibacterial mechanism of action of the synthesized maleamate-containing nanosystems and whose findings showed oxidative stress generation in bacterial cells. All the prepared nanomaterials were also tested as catalysts in the “solvent free” selective oxidation of benzyl alcohol, to observe if there is a potential correlation between the catalytic oxidation capacity of the materials and the observed oxidative stress in bacteria. This may help in the future, for a more accurate rational design of antibacterial nanosystems, based on their observed catalytic oxidation activity.

Recent Advances in Application of Azobenzenes Grafted on Mesoporous Silica Nanoparticles in Controlled Drug Delivery Systems Using Light as External Stimulus

2020 ◽  
Vol 20 (11) ◽  
pp. 1001-1016
Author(s):  
Sandra Ramírez-Rave ◽  
María Josefa Bernad-Bernad ◽  
Jesús Gracia-Mora ◽  
Anatoly K. Yatsimirsky
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
Delivery Systems ◽  
Surface Reactivity ◽  
External Stimulus ◽  
Recent Advances

Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.

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