Advances in the Use of Multifunctional Mesoporous Silica Nanoparticles and Related Nanomaterials as Carriers for the Cancer Treatment

2018 ◽  
Vol 19 (2) ◽  
pp. 131-141 ◽  
Author(s):  
Chunyu Song ◽  
Xinghua Wang ◽  
Yujun Wang ◽  
Hongbo Yu ◽  
Yali Cui ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Cancer Treatment ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles

Cancer cell membrane-cloaked mesoporous silica nanoparticles with a pH-sensitive gatekeeper for cancer treatment

2019 ◽  
Vol 175 ◽  
pp. 477-486 ◽  
Author(s):  
Chang-Ming Liu ◽  
Guang-Bing Chen ◽  
Hui-Hong Chen ◽  
Jia-Bin Zhang ◽  
Hui-Zhang Li ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Mesoporous Silica ◽  
Cancer Treatment ◽  
Silica Nanoparticles ◽  
Cancer Cell ◽  
Mesoporous Silica Nanoparticles ◽  
Ph Sensitive

scholarly journals Mesoporous Silica Nanoparticles as Carriers for Therapeutic Biomolecules

Pharmaceutics ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 432 ◽  
Author(s):  
Rafael R. Castillo ◽  
Daniel Lozano ◽  
María Vallet-Regí
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Nucleic Acids ◽  
Cancer Treatment ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Therapeutic Action ◽  
The Creation

The enormous versatility of mesoporous silica nanoparticles permits the creation of a large number of nanotherapeutic systems for the treatment of cancer and many other pathologies. In addition to the controlled release of small drugs, these materials allow a broad number of molecules of a very different nature and sizes. In this review, we focus on biogenic species with therapeutic abilities (proteins, peptides, nucleic acids, and glycans), as well as how nanotechnology, in particular silica-based materials, can help in establishing new and more efficient routes for their administration. Indeed, since the applicability of those combinations of mesoporous silica with bio(macro)molecules goes beyond cancer treatment, we address a classification based on the type of therapeutic action. Likewise, as illustrative content, we highlight the most typical issues and problems found in the preparation of those hybrid nanotherapeutic materials.

Mesoporous silica nanoparticles as a versatile nanocarrier for cancer treatment: A review

2021 ◽  
Vol 328 ◽  
pp. 115417
Author(s):  
Arezoo Sodagar Taleghani ◽  
Ali Taghvaie Nakhjiri ◽  
Mohammad Javad Khakzad ◽  
Seyed Mahdi Rezayat ◽  
Pedram Ebrahimnejad ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Cancer Treatment ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles

scholarly journals Progress in Mesoporous Silica Nanoparticles as Drug Delivery Agents for Cancer Treatment

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 152
Author(s):  
Eleen Dayana Mohamed Isa ◽  
Haslina Ahmad ◽  
Mohd Basyaruddin Abdul Rahman ◽  
Martin R. Gill
Keyword(s):  
Drug Delivery ◽  
Surface Modification ◽  
Mesoporous Silica ◽  
Cancer Treatment ◽  
Silica Nanoparticles ◽  
High Stability ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
High Surface Area ◽  
Surgical Removal

Cancer treatment and therapy have made significant leaps and bounds in these past decades. However, there are still cases where surgical removal is impossible, metastases are challenging, and chemotherapy and radiotherapy pose severe side effects. Therefore, a need to find more effective and specific treatments still exists. One way is through the utilization of drug delivery agents (DDA) based on nanomaterials. In 2001, mesoporous silica nanoparticles (MSNs) were first used as DDA and have gained considerable attention in this field. The popularity of MSNs is due to their unique properties such as tunable particle and pore size, high surface area and pore volume, easy functionalization and surface modification, high stability and their capability to efficiently entrap cargo molecules. This review describes the latest advancement of MSNs as DDA for cancer treatment. We focus on the fabrication of MSNs, the challenges in DDA development and how MSNs address the problems through the development of smart DDA using MSNs. Besides that, MSNs have also been applied as a multifunctional DDA where they can serve in both the diagnostic and treatment of cancer. Overall, we argue MSNs provide a bright future for both the diagnosis and treatment of cancer.

Sign in / Sign up

Export Citation Format

Share Document