scholarly journals Preparation and Characterization of ACE2 Receptor Inhibitor-Loaded Chitosan Hydrogels for Nasal Formulation to Reduce the Risk of COVID-19 Viral Infection

ACS Omega ◽  
2022 ◽  
Author(s):  
Barbara Vörös-Horváth ◽  
Pavo Živković ◽  
Krisztina Bánfai ◽  
Judit Bóvári-Biri ◽  
Judit Pongrácz ◽  
...  
Keyword(s):  
Viral Infection ◽  
Chitosan Hydrogels ◽  
Receptor Inhibitor

scholarly journals Modelling Degradation and Replication Kinetics of the Zika Virus In Vitro Infection

Viruses ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 547
Author(s):  
Veronika Bernhauerová ◽  
Veronica V. Rezelj ◽  
Marco Vignuzzi
Keyword(s):  
Mathematical Model ◽  
Viral Infection ◽  
Host Cell ◽  
Decay Time ◽  
Zika Virus ◽  
Infectious Virus ◽  
Numerical Characterization ◽  
The Mathematical Model

Mathematical models of in vitro viral kinetics help us understand and quantify the main determinants underlying the virus–host cell interactions. We aimed to provide a numerical characterization of the Zika virus (ZIKV) in vitro infection kinetics, an arthropod-borne emerging virus that has gained public recognition due to its association with microcephaly in newborns. The mathematical model of in vitro viral infection typically assumes that degradation of extracellular infectious virus proceeds in an exponential manner, that is, each viral particle has the same probability of losing infectivity at any given time. We incubated ZIKV stock in the cell culture media and sampled with high frequency for quantification over the course of 96 h. The data showed a delay in the virus degradation in the first 24 h followed by a decline, which could not be captured by the model with exponentially distributed decay time of infectious virus. Thus, we proposed a model, in which inactivation of infectious ZIKV is gamma distributed and fit the model to the temporal measurements of infectious virus remaining in the media. The model was able to reproduce the data well and yielded the decay time of infectious ZIKV to be 40 h. We studied the in vitro ZIKV infection kinetics by conducting cell infection at two distinct multiplicity of infection and measuring viral loads over time. We fit the mathematical model of in vitro viral infection with gamma distributed degradation time of infectious virus to the viral growth data and identified the timespans and rates involved within the ZIKV-host cell interplay. Our mathematical analysis combined with the data provides a well-described example of non-exponential viral decay dynamics and presents numerical characterization of in vitro infection with ZIKV.

scholarly journals Deep sequencing analysis of viral infection and evolution allows rapid and detailed characterization of viral mutant spectrum

2015 ◽  
Vol 31 (13) ◽  
pp. 2141-2150 ◽  
Author(s):  
Ofer Isakov ◽  
Antonio V. Bordería ◽  
David Golan ◽  
Amir Hamenahem ◽  
Gershon Celniker ◽  
...  
Keyword(s):  
Viral Infection ◽  
Deep Sequencing ◽  
Sequencing Analysis ◽  
Detailed Characterization ◽  
Viral Mutant ◽  
Mutant Spectrum ◽  
Deep Sequencing Analysis

Attainment and characterization of carboxymethyl chitosan hydrogels by enzymatic cross-linking

2019 ◽  
Vol 138 (5) ◽  
pp. 3635-3643
Author(s):  
Andreia de Araújo Morandim-Giannetti ◽  
Patrick de Oliveira Wecchi ◽  
Paula de Araújo Silvério ◽  
Regina Carlstron ◽  
Patrícia Alessandra Bersanetti
Keyword(s):  
Carboxymethyl Chitosan ◽  
Cross Linking ◽  
Chitosan Hydrogels

scholarly journals Immunological Characterization of the Teleost Adipose Tissue and Its Modulation in Response to Viral Infection and Fat-Content in the Diet

PLoS ONE ◽  
2014 ◽  
Vol 9 (10) ◽  
pp. e110920 ◽  
Author(s):  
Jaime Pignatelli ◽  
Rosario Castro ◽  
Aitor González Granja ◽  
Beatriz Abós ◽  
Lucia González ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Viral Infection ◽  
Fat Content ◽  
Immunological Characterization

Synthesis and Characterization of Chitosan Hydrogels Containing 5-Aminosalicylic Acid Nanopendents for Colon: Specific Drug Delivery

2010 ◽  
Vol 99 (12) ◽  
pp. 4955-4961 ◽  
Author(s):  
Mohammad Reza Saboktakin ◽  
Roya M. Tabatabaie ◽  
Abel Maharramov ◽  
Mohammad Ali Ramazanov
Keyword(s):  
Drug Delivery ◽  
Synthesis And Characterization ◽  
Specific Drug ◽  
Aminosalicylic Acid ◽  
Colon Specific Drug Delivery ◽  
Chitosan Hydrogels

Characterization of PVA (Polyvinyl Alcohol)/Chitosan Hydrogels as Vascular Tissue Engineering Scaffolds

2008 ◽  
Vol 269 (1) ◽  
pp. NA-NA
Author(s):  
Nihal Engin Vrana ◽  
Yurong Liu ◽  
Garret Brian McGuinness ◽  
Paul Aidan Cahill
Keyword(s):  
Tissue Engineering ◽  
Polyvinyl Alcohol ◽  
Vascular Tissue ◽  
Vascular Tissue Engineering ◽  
Tissue Engineering Scaffolds ◽  
Chitosan Hydrogels

The expression and functional characterization of RIG-I-like receptors (RLRs) of mast cells in response to viral infection

2013 ◽  
Vol 69 (2) ◽  
pp. e81
Author(s):  
Mizuho Takeuchi ◽  
Minoru Fukuda ◽  
Hiroko Ushio ◽  
Junko Kawasaki ◽  
Francois Niyonsaba ◽  
...  
Keyword(s):  
Mast Cells ◽  
Viral Infection ◽  
Functional Characterization

scholarly journals Characterization of a Novel Binding Protein for Fortilin/TCTP — Component of a Defense Mechanism against Viral Infection in Penaeus monodon

PLoS ONE ◽  
2012 ◽  
Vol 7 (3) ◽  
pp. e33291 ◽  
Author(s):  
Tanate Panrat ◽  
Patuma Sinthujaroen ◽  
Benjamas Nupan ◽  
Warapond Wanna ◽  
Martti Tapani Tammi ◽  
...  
Keyword(s):  
Viral Infection ◽  
Defense Mechanism ◽  
Binding Protein ◽  
Penaeus Monodon
Sign in / Sign up

Export Citation Format

Share Document