Gracilaria lemaneiformis Polysaccharide as Integrin-Targeting Surface Decorator of Selenium Nanoparticles to Achieve Enhanced Anticancer Efficacy

2014 ◽  
Vol 6 (16) ◽  
pp. 13738-13748 ◽  
Author(s):  
Wenting Jiang ◽  
Yuanting Fu ◽  
Fang Yang ◽  
Yufeng Yang ◽  
Ting Liu ◽  
...  
Keyword(s):  
Selenium Nanoparticles ◽  
Gracilaria Lemaneiformis ◽  
Anticancer Efficacy

Differential effects of amino acid surface decoration on the anticancer efficacy of selenium nanoparticles

2014 ◽  
Vol 43 (4) ◽  
pp. 1854-1861 ◽  
Author(s):  
Yanxian Feng ◽  
Jianyu Su ◽  
Zhennan Zhao ◽  
Wenjie Zheng ◽  
Hualian Wu ◽  
...  
Keyword(s):  
Amino Acid ◽  
Selenium Nanoparticles ◽  
Anticancer Efficacy ◽  
Differential Effects ◽  
Surface Decoration

scholarly journals BIOGENIC SELENIUM NANOPARTICLES FOR THEIR THERAPEUTIC APPLICATION

2019 ◽  
pp. 4-9
Author(s):  
AWANISH KUMAR ◽  
KUMAR SURANJIT PRASAD
Keyword(s):  
Trace Element ◽  
Environmental Remediation ◽  
Pharmaceutical Research ◽  
Selenium Nanoparticles ◽  
Elemental Selenium ◽  
Essential Trace Element ◽  
Natural Ecosystems ◽  
Anticancer Efficacy ◽  
Living Organisms ◽  
Biogenic Selenium Nanoparticles

Biosynthesis is an eloquent, safe, biocompatible, eco-friendly, and recyclable way of preparing selenium nanoparticles (SeNPs). Selenium occurs in multiple oxidation states, for example, +6, +4, 0, or −2. Selenium (Se) is an essential trace element with a very narrow margin between the lowest acceptable levels of intake and toxicity. Selenium is an essential trace element required for all living organisms. Despite its essentiality, selenium is a potentially toxic element to natural ecosystems due to its bioaccumulation potential that is why it is biologically available in the environment. Selenium is a trace element commonly found in materials of the earth’s crust, and it is essential for humans, animals, and plants. Oxyanions of selenium, that is selenite and selenate, are biologically available. Selenium in the form of selenate ion (SeO42−) is more toxic to most organisms than selenite (SeO32−). Contrarily, elemental selenium (Se0) is inOsoluble and less toxic in comparison to other forms of selenium. Nanoselenium (Se0) in the range of 100–500 nm has similar bioavailability to other forms of selenium into plants, animals, humans, and microorganisms. Biologically synthesized SeNP has many biological applications in the field of medical and pharmaceutical research to combat threats to human health. Biogenic SeNPs have anticancer (cytotoxic) activity, antioxidant activity, and antimicrobial activity. Researches are going on with special interest of SeNPs. Conjugation of antibiotics with SeNPs enhances their anticancer efficacy. SeNPs have also applications in nanobiosensors and environmental remediation.

scholarly journals GE11 peptide conjugated selenium nanoparticles for EGFR targeted oridonin delivery to achieve enhanced anticancer efficacy by inhibiting EGFR-mediated PI3K/AKT and Ras/Raf/MEK/ERK pathways

Drug Delivery ◽  
2017 ◽  
Vol 24 (1) ◽  
pp. 1549-1564 ◽  
Author(s):  
Jiang Pi ◽  
Jinhuan Jiang ◽  
Huaihong Cai ◽  
Fen Yang ◽  
Hua Jin ◽  
...  
Keyword(s):  
Selenium Nanoparticles ◽  
Anticancer Efficacy

Design and Characterization of a Cancer-Targeted Drug Co-Delivery System Composed of Liposomes and Selenium Nanoparticles

2020 ◽  
Vol 20 (9) ◽  
pp. 5295-5304
Author(s):  
Guangshan Xuan ◽  
Min Zhang ◽  
Yang Chen ◽  
Shan Huang ◽  
Imshik Lee
Keyword(s):  
Folic Acid ◽  
Zeta Potential ◽  
Cellular Uptake ◽  
Delivery System ◽  
Mtt Assay ◽  
Hela Cells ◽  
Selenium Nanoparticles ◽  
Spherical Particles ◽  
Anticancer Efficacy ◽  
Targeted Drug

A drug co-delivery system composed of selenium nanoparticles (SeNPs) has attracted increasing interest due to its ability to increase the anticancer efficacy against multidrug-resistant cancer cells. In this study, a cancer-targeted drug co-delivery system combining fluorescein-loaded liposomes and SeNPs was designed and evaluated. The system was developed by coating SeNPs and fluorescein-loaded liposomes with folic acid-chitosan conjugates (FA-CS-SeNPs-Lips). Folic acid-chitosan conjugates (FA-CS) were synthesized by coupling folic acid (FA) with chitosan (CS), and the structure was confirmed by performing Fourier transform spectroscopy (FT-IR) and nuclear magnetic resonance (1H-NMR) spectroscopy. Dynamic light scattering (DLS) measurements and transmission electron microscopy (TEM) were used to evaluate the particle size, Zeta potential, and morphology. The cytotoxicity of SeNPs coated with FA-CS conjugates (FA-CS-SeNPs) toward A549 cells and HeLa cells was examined using the MTT assay. The cancer-targeting ability and drug release behaviors were evaluated in vitro by measuring the cellular uptake of fluorescein and dialysis, respectively. The FA-CS-SeNPs were uniform, spherical particles with a ~50 nm diameter and high positive Zeta potential (+57.7 mV). Based on the results of the MTT assay, FA-CS-SeNPs displayed a more significant increase in the anticancer efficacy in HeLa cells than CS-SeNPs. FA-CS-SeNPs-Lips not only slowly released fluorescein but also specifically targeted HeLa cells through selective binding between folate and folate receptors to increase the cellular uptake of fluorescein.

scholarly journals Surface decoration by Spirulina polysaccharide enhances the cellular uptake and anticancer efficacy of selenium nanoparticles

2012 ◽  
pp. 835 ◽  
Author(s):  
Tianfeng Chen ◽  
Yang ◽  
Tang ◽  
Zhong ◽  
Bai ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Selenium Nanoparticles ◽  
Anticancer Efficacy ◽  
Surface Decoration

Potentiation of in Vivo Anticancer Efficacy of Selenium Nanoparticles by Mushroom Polysaccharides Surface Decoration

2019 ◽  
Vol 67 (10) ◽  
pp. 2865-2876 ◽  
Author(s):  
Delong Zeng ◽  
Jianfu Zhao ◽  
Kar-Him Luk ◽  
Siu-To Cheung ◽  
Ka-Hing Wong ◽  
...  
Keyword(s):  
Selenium Nanoparticles ◽  
Anticancer Efficacy ◽  
Surface Decoration

Positive Surface Charge Enhances Selective Cellular Uptake and Anticancer Efficacy of Selenium Nanoparticles

2012 ◽  
Vol 51 (16) ◽  
pp. 8956-8963 ◽  
Author(s):  
Bo Yu ◽  
Yibo Zhang ◽  
Wenjie Zheng ◽  
Cundong Fan ◽  
Tianfeng Chen
Keyword(s):  
Surface Charge ◽  
Cellular Uptake ◽  
Selenium Nanoparticles ◽  
Anticancer Efficacy ◽  
Positive Surface Charge

Controlling the phase and morphology of amorphous Se nanoparticles: their prolonged stabilization and anticancer efficacy

2018 ◽  
Vol 54 (63) ◽  
pp. 8753-8756 ◽  
Author(s):  
Apurav Guleria ◽  
Snigdha Chakraborty ◽  
Suman Neogy ◽  
Dharmendra K. Maurya ◽  
Soumyakanti Adhikari
Keyword(s):  
Amorphous Selenium ◽  
Selenium Nanoparticles ◽  
Biological Applications ◽  
Anticancer Efficacy ◽  
Se Nanoparticles

Resolving issues related to the synthesis and stabilization of amorphous selenium nanoparticles: recycling of a matrix and promising biological applications.

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