Controlling the phase and morphology of amorphous Se nanoparticles: their prolonged stabilization and anticancer efficacy

2018 ◽  
Vol 54 (63) ◽  
pp. 8753-8756 ◽  
Author(s):  
Apurav Guleria ◽  
Snigdha Chakraborty ◽  
Suman Neogy ◽  
Dharmendra K. Maurya ◽  
Soumyakanti Adhikari
Keyword(s):  
Amorphous Selenium ◽  
Selenium Nanoparticles ◽  
Biological Applications ◽  
Anticancer Efficacy ◽  
Se Nanoparticles

Resolving issues related to the synthesis and stabilization of amorphous selenium nanoparticles: recycling of a matrix and promising biological applications.

Differential effects of amino acid surface decoration on the anticancer efficacy of selenium nanoparticles

2014 ◽  
Vol 43 (4) ◽  
pp. 1854-1861 ◽  
Author(s):  
Yanxian Feng ◽  
Jianyu Su ◽  
Zhennan Zhao ◽  
Wenjie Zheng ◽  
Hualian Wu ◽  
...  
Keyword(s):  
Amino Acid ◽  
Selenium Nanoparticles ◽  
Anticancer Efficacy ◽  
Differential Effects ◽  
Surface Decoration

scholarly journals BIOGENIC SELENIUM NANOPARTICLES FOR THEIR THERAPEUTIC APPLICATION

2019 ◽  
pp. 4-9
Author(s):  
AWANISH KUMAR ◽  
KUMAR SURANJIT PRASAD
Keyword(s):  
Trace Element ◽  
Environmental Remediation ◽  
Pharmaceutical Research ◽  
Selenium Nanoparticles ◽  
Elemental Selenium ◽  
Essential Trace Element ◽  
Natural Ecosystems ◽  
Anticancer Efficacy ◽  
Living Organisms ◽  
Biogenic Selenium Nanoparticles

Biosynthesis is an eloquent, safe, biocompatible, eco-friendly, and recyclable way of preparing selenium nanoparticles (SeNPs). Selenium occurs in multiple oxidation states, for example, +6, +4, 0, or −2. Selenium (Se) is an essential trace element with a very narrow margin between the lowest acceptable levels of intake and toxicity. Selenium is an essential trace element required for all living organisms. Despite its essentiality, selenium is a potentially toxic element to natural ecosystems due to its bioaccumulation potential that is why it is biologically available in the environment. Selenium is a trace element commonly found in materials of the earth’s crust, and it is essential for humans, animals, and plants. Oxyanions of selenium, that is selenite and selenate, are biologically available. Selenium in the form of selenate ion (SeO42−) is more toxic to most organisms than selenite (SeO32−). Contrarily, elemental selenium (Se0) is inOsoluble and less toxic in comparison to other forms of selenium. Nanoselenium (Se0) in the range of 100–500 nm has similar bioavailability to other forms of selenium into plants, animals, humans, and microorganisms. Biologically synthesized SeNP has many biological applications in the field of medical and pharmaceutical research to combat threats to human health. Biogenic SeNPs have anticancer (cytotoxic) activity, antioxidant activity, and antimicrobial activity. Researches are going on with special interest of SeNPs. Conjugation of antibiotics with SeNPs enhances their anticancer efficacy. SeNPs have also applications in nanobiosensors and environmental remediation.

Gracilaria lemaneiformis Polysaccharide as Integrin-Targeting Surface Decorator of Selenium Nanoparticles to Achieve Enhanced Anticancer Efficacy

2014 ◽  
Vol 6 (16) ◽  
pp. 13738-13748 ◽  
Author(s):  
Wenting Jiang ◽  
Yuanting Fu ◽  
Fang Yang ◽  
Yufeng Yang ◽  
Ting Liu ◽  
...  
Keyword(s):  
Selenium Nanoparticles ◽  
Gracilaria Lemaneiformis ◽  
Anticancer Efficacy

scholarly journals Folate-targeted selenium nanoparticles deliver therapeutic siRNA to improve hepatocellular carcinoma therapy

RSC Advances ◽  
2018 ◽  
Vol 8 (46) ◽  
pp. 25932-25940 ◽  
Author(s):  
Yu Xia ◽  
Mingqi Zhao ◽  
Yi Chen ◽  
Liang Hua ◽  
Tiantian Xu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Folic Acid ◽  
Selenium Nanoparticles ◽  
Effective Strategy ◽  
Se Nanoparticles

We provide an effective strategy for the design of tumor-targeted nanodrugs against hepatocellular carcinoma by functionalising Se nanoparticles with polyethylenimine linked with folic acid and siRNA.

scholarly journals GE11 peptide conjugated selenium nanoparticles for EGFR targeted oridonin delivery to achieve enhanced anticancer efficacy by inhibiting EGFR-mediated PI3K/AKT and Ras/Raf/MEK/ERK pathways

Drug Delivery ◽  
2017 ◽  
Vol 24 (1) ◽  
pp. 1549-1564 ◽  
Author(s):  
Jiang Pi ◽  
Jinhuan Jiang ◽  
Huaihong Cai ◽  
Fen Yang ◽  
Hua Jin ◽  
...  
Keyword(s):  
Selenium Nanoparticles ◽  
Anticancer Efficacy

scholarly journals Amorphous Selenium Nanoparticles Improve Vascular Function in Rats With Chronic Isocarbophos Poisoning via Inhibiting the Apoptosis of Vascular Endothelial Cells

2021 ◽  
Vol 9 ◽  
Author(s):  
Moli Zhu ◽  
Zhitao Gao ◽  
Yutian Fu ◽  
Yue Qiu ◽  
Keke Huang ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Vascular Function ◽  
Caspase 3 ◽  
Vascular Dysfunction ◽  
Amorphous Selenium ◽  
Selenium Nanoparticles ◽  
Total Carbon ◽  
Male Rats ◽  
Intragastric Administration ◽  
Vascular Endothelial

AimThis study aimed to investigate the preventive effect and possible mechanism of amorphous selenium nanoparticles (A-SeQDs) on isocarbophos induced vascular dysfunction.MethodsA-SeQDs was made by auto redox decomposition of selenosulfate precursor. Male rats were given isocarbophos (0.5 mg/kg/2 days) by intragastric administration for 16 weeks to induce vascular dysfunction. During the course, A-SeQDs (50 mg/kg/day) was added to the water from week 5. Then, the rats were killed to observe and test the influence of A-SeQDs on the vascular dysfunction induced by isocarbophos. Finally, human umbilical vein endothelial cells (HUVECs) were treated with 10% DMEM of isocarbophos (100 μM) for 5 days to detect the related indexes. Before the use of isocarbophos treatment, different drugs were given.ResultsA-SeQDs could reduce total carbon dioxide, MDA, VCAM-1, ICAM-1, IL-1, and IL-6 while increasing oxygen saturation, NO content, and SOD activity in rats. A-SeQDs also resulted in relatively normal vascular morphology, and the expression of sodium hydrogen exchanger 1 (NHE1) and caspase-3 decreased in rats. Furthermore, in HUVECs treated with isocarbophos, A-SeQDs maintained mitochondrial membrane potential, inhibited the cleaved caspase-3 expression, and released cytochrome c from mitochondria to cytosol.ConclusionA-SeQDs can inhibit the apoptosis of HUVECs through the mitochondrial pathway, and effectively treat the impairment of vascular endothelial function caused by isocarbophos, which is NHE1-dependent.

A 10 minute approach for the phase specific synthesis of Se nanoparticles with tunable morphology: their anticancer efficacy and the role of an ionic liquid

2020 ◽  
Vol 44 (11) ◽  
pp. 4578-4589 ◽  
Author(s):  
Apurav Guleria ◽  
Dharmendra K. Maurya ◽  
Suman Neogy ◽  
B. S. Raorane ◽  
Anil K. Debnath ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Current Work ◽  
Anticancer Efficacy ◽  
Se Nanoparticles ◽  
Specific Synthesis ◽  
Tunable Morphology

The current work demonstrates a rapid and highly facile controlled phase-specific synthesis of Se nanoparticles, their anticancer efficacy and the 3-in-1 role of a RTIL.

Design and Characterization of a Cancer-Targeted Drug Co-Delivery System Composed of Liposomes and Selenium Nanoparticles

2020 ◽  
Vol 20 (9) ◽  
pp. 5295-5304
Author(s):  
Guangshan Xuan ◽  
Min Zhang ◽  
Yang Chen ◽  
Shan Huang ◽  
Imshik Lee
Keyword(s):  
Folic Acid ◽  
Zeta Potential ◽  
Cellular Uptake ◽  
Delivery System ◽  
Mtt Assay ◽  
Hela Cells ◽  
Selenium Nanoparticles ◽  
Spherical Particles ◽  
Anticancer Efficacy ◽  
Targeted Drug

A drug co-delivery system composed of selenium nanoparticles (SeNPs) has attracted increasing interest due to its ability to increase the anticancer efficacy against multidrug-resistant cancer cells. In this study, a cancer-targeted drug co-delivery system combining fluorescein-loaded liposomes and SeNPs was designed and evaluated. The system was developed by coating SeNPs and fluorescein-loaded liposomes with folic acid-chitosan conjugates (FA-CS-SeNPs-Lips). Folic acid-chitosan conjugates (FA-CS) were synthesized by coupling folic acid (FA) with chitosan (CS), and the structure was confirmed by performing Fourier transform spectroscopy (FT-IR) and nuclear magnetic resonance (1H-NMR) spectroscopy. Dynamic light scattering (DLS) measurements and transmission electron microscopy (TEM) were used to evaluate the particle size, Zeta potential, and morphology. The cytotoxicity of SeNPs coated with FA-CS conjugates (FA-CS-SeNPs) toward A549 cells and HeLa cells was examined using the MTT assay. The cancer-targeting ability and drug release behaviors were evaluated in vitro by measuring the cellular uptake of fluorescein and dialysis, respectively. The FA-CS-SeNPs were uniform, spherical particles with a ~50 nm diameter and high positive Zeta potential (+57.7 mV). Based on the results of the MTT assay, FA-CS-SeNPs displayed a more significant increase in the anticancer efficacy in HeLa cells than CS-SeNPs. FA-CS-SeNPs-Lips not only slowly released fluorescein but also specifically targeted HeLa cells through selective binding between folate and folate receptors to increase the cellular uptake of fluorescein.

scholarly journals Growth Mechanism of Amorphous Selenium Nanoparticles Synthesized byShewanellasp. HN-41

2010 ◽  
Vol 74 (4) ◽  
pp. 696-700 ◽  
Author(s):  
Kawai TAM ◽  
Cuong Tu HO ◽  
Ji-Hoon LEE ◽  
Min LAI ◽  
Chong Hyun CHANG ◽  
...  
Keyword(s):  
Growth Mechanism ◽  
Amorphous Selenium ◽  
Selenium Nanoparticles
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