Second-Generation Computer-Assisted Inhibitor Design Method

Author(s):  
Renee L. DesJarlais ◽  
George L. Seibel ◽  
Irwin D. Kuntz
Joints ◽  
2018 ◽  
Vol 06 (02) ◽  
pp. 090-094 ◽  
Author(s):  
Matteo Denti ◽  
Francesco Soldati ◽  
Francesca Bartolucci ◽  
Emanuela Morenghi ◽  
Laura De Girolamo ◽  
...  

Purpose The development of new computer-assisted navigation technologies in total knee arthroplasty (TKA) has attracted great interest; however, the debate remains open as to the real reliability of these systems. We compared conventional TKA with last generation computer-navigated TKA to find out if navigation can reach better radiographic and clinical outcomes. Methods Twenty patients with tricompartmental knee osteoarthritis were prospectively selected for conventional TKA (n = 10) or last generation computer-navigated TKA (n = 10). Data regarding age, gender, operated side, and previous surgery were collected. All 20 patients received the same cemented posterior-stabilized TKA. The same surgical instrumentation, including alignment and cutting guides, was used for both the techniques. A single radiologist assessed mechanical alignment and tibial slope before and after surgery. A single orthopaedic surgeon performed clinical evaluation at 1 year after the surgery. Wilcoxon's test was used to compare the outcomes of the two groups. Statistical significance was set at p < 0.05. Results No significant differences in mechanical axis or tibial slope was found between the two groups. The clinical outcome was equally good with both techniques. At a mean follow-up of 15.5 months (range, 13–25 months), all patients from both groups were generally satisfied with a full return to daily activities and without a significance difference between them. Conclusion Our data showed that clinical and radiological outcomes of TKA were not improved by the use of computer-assisted instruments, and that the elevated costs of the system are not warranted. Level of Evidence This is a Level II, randomized clinical trial.


Author(s):  
Alperen Acemoglu ◽  
Nikhil Deshpande ◽  
Jinoh Lee ◽  
Darwin G. Caldwell ◽  
Leonardo S. Mattos

2013 ◽  
Vol 804 ◽  
pp. 167-173
Author(s):  
Huan Wen Ding ◽  
Guang Wen Yu ◽  
Qiang Tu ◽  
Jian Jian Shen ◽  
Ying Jun Wang

To establish a new three-dimensional (3D) digital design method for osteotomy and assess its application value in the surgical treatment of hemivertebrae. Preoperative 3D digital designs for osteotomy of the hemivertebrae were performed, which included computer simulation of the osteotomy and the internal fixation process, and computer-assisted design (CAD) of the templates for osteotomy of the hemivertebrae, pedicle screw positioning, and internal fixation rods. Template-guided osteotomy of the hemivertebrae plus pedicle screw and rod internal fixation were accurately implemented. The preoperative use of this new computer-aided 3D digitized and paperless surgical design can improve the safety, accuracy, and operative time for osteotomy in the treatment of hemivertebrae.


Author(s):  
Philip B.K. Potter

Foreign policy analysis (FPA) is the study of how states, or the individuals that lead them, make foreign policy, execute foreign policy, and react to the foreign policies of other states. This topical breadth results in a subfield that encompasses a variety of questions and levels of analysis, and a correspondingly diverse set of methodological approaches. There are four methods which have become central in foreign policy analysis: archival research, content analysis, interviews, and focus groups. The first major phase of FPA research is termed “comparative foreign policy.” Proponents of comparative foreign policy sought to achieve comprehensive theories of foreign policy behavior through quantitative analysis of “events” data. An important strand of this behavioral work addressed the relationship between trade dependence and foreign policy compliance. On the other hand, second-generation FPA methodology largely abandoned universalized theory-building in favor of historical methods and qualitative analysis. Second-generation FPA researchers place particular emphasis on developing case study methodologies driven by social science principles. Meanwhile, the third-generation of FPA scholarship combines innovative quantitative and qualitative methods. Several methods of foreign policy analysis used by third-generation FPA researchers include computer assisted coding, experiments, simulation, surveys, network analysis, and prediction markets. Ultimately, additional attention should be given to determining the degree to which current methods of foreign policy analysis allow predictive or prescriptive conclusions. FPA scholars should also focus more in reengaging foreign policy analysis with the core of international relations research.


1977 ◽  
Vol 35 ◽  
pp. 195-197
Author(s):  
D.D. Polojentsev

The Pulkovo Observatory computing laboratory began its activities in 1956. Originally it was equipped with card-punched machines. An essential work of processing astronomical data was carried out with the help of these machines ([1] and other).With the development of the computing techniques in the USSR, the laboratory has been equipped with more modern computing devices. At present the Laboratory disposes of the third generation computer ES-1020 of the Ryad type, as well as the second generation computers Minsk-22 and Nairi-K.


2011 ◽  
Vol 368-373 ◽  
pp. 3857-3861
Author(s):  
Lei Bai ◽  
Zeng Feng Yan ◽  
Shu Ping Zhang

Partial current rules of the National Standard of Fire Code are disjointed from the current development of large commercial building; as a result, part of the design cannot be carried out according to the specifications. The new digital fire control design method can solve this difficulty. This paper is to take a large commercial building as an engineering example, introducing the new design concept of “independent fire protection unit” and “quasi-safety area” to adjust the program; then, on the basis of fire safety engineering principles, it uses the computer-assisted method to predict and assess the dangers of fire and the safety of evacuation, and thus demonstrating the feasibility of this method.


2014 ◽  
Vol 1036 ◽  
pp. 388-393
Author(s):  
Gheorghe Pleşu

The complex helical surfaces specific for the rotors of the helical compressors and of the screw pumps imply the production of a series of tools providing a high productivity. The staggered-tooth milling cutter achieve these conditions but their design gives rise to difficult problems. In order to optimize their parameters and to facilitate their design, a package of programs has been created to select the constructive parameters of the tool, to calculate the profiles of the plates, the angles of the surface of section, the dimensions of the elements of attachment. In order to include all these elements in an efficient system of design, a series of regular calculations were applied for various parameters that were then included through the CAD software for design and documentation AutoCAD; at the same time, several applications of verification, construction and simulation of the functioning of the tool and of the cutting process were designed. The method applied in this case reduced to a considerable extent the time of design and it also improved the constructive solutions of the staggered-tooth milling cutter.


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