Phosphorylcholine-Based pH-Responsive Diblock Copolymer Micelles as Drug Delivery Vehicles:  Light Scattering, Electron Microscopy, and Fluorescence Experiments

2006 ◽  
Vol 7 (3) ◽  
pp. 817-828 ◽  
Author(s):  
Cristiano Giacomelli ◽  
Lucile Le Men ◽  
Redouane Borsali ◽  
Joséphine Lai-Kee-Him ◽  
Alain Brisson ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Drug Delivery ◽  
Light Scattering ◽  
Diblock Copolymer ◽  
Ph Responsive ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Copolymer Micelles

scholarly journals Functionalized β-Cyclodextrin Immobilized on Ag-Embedded Silica Nanoparticles as a Drug Carrier

2019 ◽  
Vol 20 (2) ◽  
pp. 315 ◽  
Author(s):  
Eun Kang ◽  
Yu Baek ◽  
Eunil Hahm ◽  
Sang Lee ◽  
Xuan-Hung Pham ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Drug Delivery ◽  
Drug Carrier ◽  
Silica Nanoparticle ◽  
Surface Modifications ◽  
Ag Nps ◽  
Drug Delivery Vehicles ◽  
Transmission Electron ◽  
Delivery Vehicles ◽  
Simple Surface

Cyclodextrins (CDs) have beneficial characteristics for drug delivery, including hydrophobic interior surfaces. Nanocarriers with β-CD ligands have been prepared with simple surface modifications as drug delivery vehicles. In this study, we synthesized β-CD derivatives on an Ag-embedded silica nanoparticle (NP) (SiO2@Ag NP) structure to load and release doxorubicin (DOX). Cysteinyl-β-CD and ethylenediamine-β-CD (EDA-β-CD) were immobilized on the surface of SiO2@Ag NPs, as confirmed by transmission electron microscopy (TEM), ultraviolet-visible (UV-Vis) spectrophotometry, and Fourier transform infrared (FTIR) spectroscopy. DOX was introduced into the β-CD on the SiO2@Ag NPs and then successfully released. Neither cysteinyl-β-CD and EDA-β-CD showed cytotoxicity, while DOX-loaded cysteinyl-β-CD and EDA-β-CD showed a significant decrease in cell viability in cancer cells. The SiO2@Ag NPs with β-CD provide a strategy for designing a nanocarrier that can deliver a drug with controlled release from modified chemical types.

scholarly journals Facile synthesis of Prussian blue nanoparticles as pH-responsive drug carriers for combined photothermal-chemo treatment of cancer

RSC Advances ◽  
2017 ◽  
Vol 7 (1) ◽  
pp. 248-255 ◽  
Author(s):  
Huajian Chen ◽  
Yan Ma ◽  
Xianwen Wang ◽  
Xiaoyi Wu ◽  
Zhengbao Zha
Keyword(s):  
Drug Delivery ◽  
Prussian Blue ◽  
Cancer Cells ◽  
Drug Carriers ◽  
High Efficacy ◽  
Ph Responsive ◽  
Facile Synthesis ◽  
Drug Delivery Vehicles ◽  
Prussian Blue Nanoparticles ◽  
Delivery Vehicles

Multifunctional PEGylated PB-DOX NPs with a lipid-PEG shell were developed as a gram-scale manner and used as novel pH-responsive drug delivery vehicles for combined photothermal-chemo treatment of cancer cells with high efficacy.

Fe3O4@carbon@zeolitic imidazolate framework-8 nanoparticles as multifunctional pH-responsive drug delivery vehicles for tumor therapy in vivo

2015 ◽  
Vol 3 (46) ◽  
pp. 9033-9042 ◽  
Author(s):  
Mengni He ◽  
Jiajia Zhou ◽  
Jian Chen ◽  
Fangcai Zheng ◽  
Dongdong Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Tumor Therapy ◽  
Controlled Drug Release ◽  
Ph Responsive ◽  
Zeolitic Imidazolate Framework ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

Controlled drug release is a promising approach for cancer therapy due to its merits of reduced systemic toxicity and enhanced antitumor efficacy.

Tailored Viscosity Reduction in Aqueous Hydroxypropylcellulose Solutions

1995 ◽  
Vol 394 ◽  
Author(s):  
Victoria A. Prevysh ◽  
Richard J. Spontak ◽  
Saad A. Khan
Keyword(s):  
Electron Microscopy ◽  
Drug Delivery ◽  
Pharmaceutical Industry ◽  
Viscosity Reduction ◽  
Self Organization ◽  
Solution Viscosity ◽  
Dynamic Rheology ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

AbstractPolysaccharides, including cellulosic derivatives such as hydroxypropylcellulose (HPC), are used extensively in the pharmaceutical industry due to their biocompatibility and self-organization properties. While drug delivery vehicles employing, for instance, aqueous polysaccharide gels are desirable, production of such gels can be hindered by tremendously high solution viscosity. In this work, we describe a novel means by which to reduce the viscosity and enhance the solubility of aqueous HPC. Here, the efficacy of several additives which promote HPC viscosity reduction through molecular salting-in is examined by dynamic rheology and light/electron microscopy.

Dendrimers: General Aspects, Applications and Structural Exploitations as Prodrug/Drug-delivery Vehicles in Current Medicine

2018 ◽  
Vol 18 (5) ◽  
pp. 439-457 ◽  
Author(s):  
Merina Mariyam ◽  
Kajal Ghosal ◽  
Sabu Thomas ◽  
Nandakumar Kalarikkal ◽  
Mahima S. Latha
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
General Aspects
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