Adhesion between Molecules and Calcium Oxalate Crystals:  Critical Interactions in Kidney Stone Formation

2003 ◽  
Vol 125 (10) ◽  
pp. 2854-2855 ◽  
Author(s):  
Xiaoxia Sheng ◽  
Michael D. Ward ◽  
Jeffrey A. Wesson
Keyword(s):  
Calcium Oxalate ◽  
Kidney Stone ◽  
Stone Formation ◽  
Calcium Oxalate Crystals ◽  
Oxalate Crystals ◽  
Kidney Stone Formation

856 Calcium oxalate crystals could be englobed by macrophages during kidney stone formation in vitro and in vivo models

2012 ◽  
Vol 11 (1) ◽  
pp. e856-e856a
Author(s):  
A. Okada ◽  
K. Taguchi ◽  
Y. Hirose ◽  
K. Niimi ◽  
Y. Fujii ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Kidney Stone ◽  
Stone Formation ◽  
Calcium Oxalate Crystals ◽  
In Vivo Models ◽  
Oxalate Crystals ◽  
Kidney Stone Formation

2086 RENAL MACROPHAGES COULD ENGLOBE CALCIUM OXALATE CRYSTALS DURING KIDNEY STONE FORMATION IN VITRO AND IN VIVO MODELS

2012 ◽  
Vol 187 (4S) ◽  
Author(s):  
Atsushi Okada ◽  
Takahiro Yasui ◽  
Kazumi Taguchi ◽  
Yasuhiko Hirose ◽  
Kazuhiro Niimi ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Kidney Stone ◽  
Stone Formation ◽  
Calcium Oxalate Crystals ◽  
In Vivo Models ◽  
Oxalate Crystals ◽  
Kidney Stone Formation

The Effect of Ethane-1-Hydroxy-1,1-Diphosphonate (EHDP) on Calcium Oxalate Crystalluria in Recurrent Renal Stone-Formers

1974 ◽  
Vol 47 (1) ◽  
pp. 13-22 ◽  
Author(s):  
W. G. Robertson ◽  
M. Peacock ◽  
R. W. Marshall ◽  
F. Knowles
Keyword(s):  
Calcium Oxalate ◽  
Stone Formation ◽  
Basal Diet ◽  
Sodium Oxalate ◽  
Calcium Oxalate Crystals ◽  
Calcium Oxalate Dihydrate ◽  
Calcium Oxalate Stone ◽  
Oxalate Crystals ◽  
Stone Formers

1. The volume, size and type of calcium oxalate crystals excreted in the urine of a group of patients with recurrent ‘idiopathic’ stones were studied on a controlled basal diet, after an oral supplement of sodium oxalate and after oral administration of ethane-1-hydroxy-1,1-diphosphonate (EHDP) for 4 weeks. 2. Before administration of EHDP the stone-formers passed the large crystals and aggregates of calcium oxalate dihydrate characteristic of recurrent calcium oxalate stone-formers. For the same level of urine saturation and crystalluria EHDP caused a significant reduction in the proportion of large crystals and aggregates excreted. Studies by light-microscopy confirmed that EHDP caused a striking change in the size and habit of calcium oxalate crystals in some but not all of the urine samples examined. 3. The decrease in average crystal size during the administration of EHDP was attributed to the observed increase in the ability of urine to inhibit the growth and aggregation of calcium oxalate crystals as measured by a growth system in vitro. 4. The possible use of EHDP as a therapeutic agent in the treatment of calcium oxalate stone-formation is discussed.

Analysis of HK-2 cells exposed to oxalate and calcium oxalate crystals: proteomic insights into the molecular mechanisms of renal injury and stone formation

2009 ◽  
Vol 38 (1) ◽  
pp. 7-15 ◽  
Author(s):  
Shushang Chen ◽  
Xiaofeng Gao ◽  
Yinghao Sun ◽  
Chuanliang Xu ◽  
Linhui Wang ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Renal Injury ◽  
Molecular Mechanisms ◽  
Stone Formation ◽  
Calcium Oxalate Crystals ◽  
Oxalate Crystals

Adhesion force between calcium oxalate monohydrate crystal and kidney epithelial cells and possible relevance for kidney stone formation

2006 ◽  
Vol 300 (1) ◽  
pp. 131-140 ◽  
Author(s):  
Yakov I. Rabinovich ◽  
Madhavan Esayanur ◽  
Saijit Daosukho ◽  
Karen J. Byer ◽  
Hassan E. El-Shall ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Calcium Oxalate ◽  
Kidney Stone ◽  
Adhesion Force ◽  
Stone Formation ◽  
Calcium Oxalate Monohydrate ◽  
Kidney Epithelial Cells ◽  
Kidney Stone Formation

scholarly journals Protective Effect of Degraded Porphyra yezoensis Polysaccharides on the Oxidative Damage of Renal Epithelial Cells and on the Adhesion and Endocytosis of Nanocalcium Oxalate Crystals

2021 ◽  
Vol 2021 ◽  
pp. 1-15
Author(s):  
Qian-Long Peng ◽  
Chuang-Ye Li ◽  
Yao-Wang Zhao ◽  
Xin-Yuan Sun ◽  
Hong Liu ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Epithelial Cells ◽  
Oxidative Damage ◽  
Protective Effect ◽  
Calcium Oxalate ◽  
Kidney Stone ◽  
Stone Formation ◽  
Porphyra Yezoensis ◽  
Renal Epithelial Cells ◽  
Kidney Stone Formation

The protective effects of Porphyra yezoensis polysaccharides (PYPs) with molecular weights of 576.2 (PYP1), 105.4 (PYP2), 22.47 (PYP3), and 3.89 kDa (PYP4) on the oxidative damage of human kidney proximal tubular epithelial (HK-2) cells and the differences in adherence and endocytosis of HK-2 cells to calcium oxalate monohydrate crystals before and after protection were investigated. Results showed that PYPs can effectively reduce the oxidative damage of oxalic acid to HK-2 cells. Under the preprotection of PYPs, cell viability increased, cell morphology improved, reactive oxygen species levels decreased, mitochondrial membrane potential increased, S phase cell arrest was inhibited, the cell apoptosis rate decreased, phosphatidylserine exposure reduced, the number of crystals adhered to the cell surface reduced, but the ability of cells to endocytose crystals enhanced. The lower the molecular weight, the better the protective effect of PYP. The results in this article indicated that PYPs can reduce the risk of kidney stone formation by protecting renal epithelial cells from oxidative damage and reducing calcium oxalate crystal adhesion, and PYP4 with the lowest molecular weight may be a potential drug for preventing kidney stone formation.

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