Glutathione Peroxidase (GPx)-like Antioxidant Activity of the Organoselenium Drug Ebselen:  Unexpected Complications with Thiol Exchange Reactions

2005 ◽  
Vol 127 (32) ◽  
pp. 11477-11485 ◽  
Author(s):  
Bani Kanta Sarma ◽  
G. Mugesh
Keyword(s):  
Antioxidant Activity ◽  
Glutathione Peroxidase ◽  
Exchange Reactions ◽  
Thiol Exchange

scholarly journals Antioxidant Activity of the Isoflavonoids from the Roots of Maackia amurensis

2013 ◽  
Vol 8 (5) ◽  
pp. 1934578X1300800 ◽  
Author(s):  
Nadezda I. Kulesh ◽  
Sergey A. Fedoreyev ◽  
Marina V. Veselova ◽  
Natalia P. Mischenko ◽  
Vladimir A. Denisenko ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Glutathione Peroxidase ◽  
Column Chromatography ◽  
Thiobarbituric Acid ◽  
Formalin Injection ◽  
Thiobarbituric Acid Reactive Substances ◽  
H Nmr ◽  
Maackia Amurensis

Seven isoflavonoids, including a new glycoside, (6a R,11a R)-medicarpin-3- O-gentiobioside (6), were isolated from the roots of Maackia amurensis using repeated column chromatography on a Toyopearl HW-50F sorbent and identified by HPLC–PDA–MS, 1H NMR, 13C, 1H–1H COSY, HSQC NMR and HMBC NMR analyses as daidzin (1), genistein-7- O-gentiobioside (2), pseudobaptigenin-7- O-gentiobioside (3), formononetin-7- O-gentiobioside (4), (6a R,11a R)-maackiain-3- O-gentiobioside (5), and 5- O-methylgenistein-7- O-gentiobioside (7). In the model of oxidative stress induced by formalin injection, the isolated isoflavone and pterocarpan glucosides 1-7 were shown to reduce the formation of malondialdehyde (MDA) and other thiobarbituric acid reactive substances (TBARS), as well as glutathione peroxidase (GPO) activity in rats.

Introduction of a catalytic triad increases the glutathione peroxidase-like activity of diaryl diselenides

2015 ◽  
Vol 13 (34) ◽  
pp. 9072-9082 ◽  
Author(s):  
Debasish Bhowmick ◽  
Govindasamy Mugesh
Keyword(s):  
Antioxidant Activity ◽  
Glutathione Peroxidase ◽  
Catalytic Triad

Glutathione peroxidase-like antioxidant activity of amine and amide-based diselenides is described.

Antioxidant Activity of Enzymatic Hydrolysates of High-Temperature Soybean Meal Pretreated with High Pressures

2015 ◽  
Vol 1092-1093 ◽  
pp. 1519-1524 ◽  
Author(s):  
Jing Xu ◽  
Yu Ting Wang ◽  
Xiao Yu Wang ◽  
Xin Ru Li ◽  
Qian Xin Dang
Keyword(s):  
Antioxidant Activity ◽  
High Pressure ◽  
Superoxide Dismutase ◽  
High Temperature ◽  
Glutathione Peroxidase ◽  
Molecular Mass ◽  
Soybean Meal ◽  
High Pressures ◽  
Relative Molecular Mass ◽  
Mda Content

Effect of high-temperature soybean meal hydrolysates was to be studied in this paper. Hhigh-temperature soybean meal was treated by high pressure. And Alcalase 2.4 L was used to hydrolyze high-temperature soybean meal, three kinds of solutions with relative molecular mass of > 10 000 Da, 5000 Da – 10 000 Da and < 5 000 Da were obtained by ultrafiltration of hydrolysates, and they were administrated mice by gastric perfusion, respectively. Levels of superoxide dismutase (SOD), glutathione peroxidase (GSH-PX) and malondialdehyde (MDA) in liver were separately tested with reagent kits. Results showed that SOD and GSH-PX activities were significantly improved and MDA content was reduced in liver of mice by hydrolysates, which indicated that high-temperature soybean meal hydrolysates can improve antioxidant indexes of mice and enhance antioxidation capacity of body.

Glutathione Peroxidase-like Antioxidant Activity of Diaryl Diselenides:  A Mechanistic Study

2001 ◽  
Vol 123 (5) ◽  
pp. 839-850 ◽  
Author(s):  
G. Mugesh ◽  
Arunashree Panda ◽  
Harkesh B. Singh ◽  
Narayan S. Punekar ◽  
Ray J. Butcher
Keyword(s):  
Antioxidant Activity ◽  
Glutathione Peroxidase ◽  
Mechanistic Study

scholarly journals In VivoAntioxidant Activity of Deacetylasperulosidic Acid in Noni

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
De-Lu Ma ◽  
Mai Chen ◽  
Chen X. Su ◽  
Brett J. West
Keyword(s):  
Antioxidant Activity ◽  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Catalase Activity ◽  
Antioxidant Properties ◽  
Superoxide Dismutase Activity ◽  
Morinda Citrifolia ◽  
Control Group ◽  
Dose Dependent

Deacetylasperulosidic acid (DAA) is a major phytochemical constituent ofMorinda citrifolia(noni) fruit. Noni juice has demonstrated antioxidant activityin vivoand in human trials. To evaluate the role of DAA in this antioxidant activity, Wistar rats were fed 0 (control group), 15, 30, or 60 mg/kg body weight per day for 7 days. Afterwards, serum malondialdehyde concentration and superoxide dismutase and glutathione peroxidase activities were measured and compared among groups. A dose-dependent reduction in malondialdehyde was evident as well as a dose-dependent increase in superoxide dismutase activity. DAA ingestion did not influence serum glutathione peroxidase activity. These results suggest that DAA contributes to the antioxidant activity of noni juice by increasing superoxide dismutase activity. The fact that malondialdehyde concentrations declined with increased DAA dose, despite the lack of glutathione peroxidase-inducing activity, suggests that DAA may also increase catalase activity. It has been previously reported that noni juice increases catalase activityin vivobut additional research is required to confirm the effect of DAA on catalase. Even so, the current findings do explain a possible mechanism of action for the antioxidant properties of noni juice that have been observed in human clinical trials.

A Novel Glutathione Peroxidase Mimic with Antioxidant Activity

2001 ◽  
Vol 387 (2) ◽  
pp. 250-256 ◽  
Author(s):  
Xiaojun Ren ◽  
Liquan Yang ◽  
Junqiu Liu ◽  
Dan Su ◽  
Delin You ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Glutathione Peroxidase ◽  
Peroxidase Mimic

Sublethal ischemia alters myocardial antioxidant activity in canine heart

1993 ◽  
Vol 264 (1) ◽  
pp. H33-H39 ◽  
Author(s):  
S. Hoshida ◽  
T. Kuzuya ◽  
H. Fuji ◽  
N. Yamashita ◽  
H. Oe ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Ischemic Myocardium ◽  
Ischemia And Reperfusion ◽  
Canine Heart ◽  
Ischemic Insult ◽  
Sod Activity ◽  
Regional Ischemia ◽  
Canine Myocardium

We examined antioxidant activity in the pre-conditioned canine myocardium with four 5-min episodes of regional ischemia and reperfusion. Immediately after repetitive brief ischemia, mitochondrial Mn-superoxide dismutase (SOD) activity in the ischemic myocardium significantly increased compared with that in the nonischemic myocardium (18.7 +/- 2.1 vs. 14.9 +/- 1.0 U/mg protein, P < 0.05). Although no difference was seen in the activity between these regions after 3 h of the sublethal ischemia, a significant increase in the activity of the ischemic myocardium reappeared after 24 h compared with that of the nonischemic myocardium (26.7 +/- 0.9 vs. 20.8 +/- 0.9 U/mg protein, P < 0.05). Mn-SOD content increased gradually in the ischemic myocardium after sublethal ischemia, with a peak after 24 h (2.8 +/- 0.1 vs. 2.1 +/- 0.1 microgram/mg protein, P < 0.05). There were no differences in the activity and content of Cu, Zn-SOD between these regions after sublethal ischemia. Activities of glutathione peroxidase and reductase were significantly higher and lower, respectively, in the ischemic myocardium than those of the nonischemic myocardium immediately after repetitive brief ischemia, but no differences between these regions were seen in activities after 3 or 24 h. These results indicate that a brief ischemic insult alters myocardial antioxidant activity not only immediately after but also 24 h after sublethal ischemia.

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