A Single Antibody Catalyzes Multiple Chemical Transformations upon Replacement of the Functionalized Small Nonprotein Components

2009 ◽  
Vol 131 (2) ◽  
pp. 456-457 ◽  
Author(s):  
Fumihiro Ishikawa ◽  
Takeshi Tsumuraya ◽  
Ikuo Fujii
Keyword(s):  
Chemical Transformations ◽  
Multiple Chemical

Doubleisomerization / cycloisomerization / aromatization of 1-(allyloxy)-2-(cyclopropylmethyl)benzenes to give 2-ethyl-3-isopropylbenzofurans using multitasking single rhodium catalyst

2021 ◽  
Author(s):  
Yuta Sato ◽  
Tsuyoshi Matsuzaki ◽  
Tsunayoshi Takehara ◽  
Makoto Sako ◽  
Takeyuki Suzuki ◽  
...  
Keyword(s):  
Rhodium Catalyst ◽  
Reaction Vessel ◽  
Chemical Transformations ◽  
Catalyst Systems ◽  
Multiple Chemical ◽  
Single Reaction

Multitasking single-catalyst systems that allow multiple chemical transformations within a single reaction vessel are important for the development of eco-compatible chemistry. Here, we have developed a rhodium-catalyzed system that transforms...

scholarly journals Infrequent Metadynamics Study of Rare-event Electrostatic Channeling

2021 ◽  
Author(s):  
Yan Xie ◽  
Scott Calabrese Barton
Keyword(s):  
Rare Event ◽  
Cascade Reactions ◽  
Single Step ◽  
Chemical Transformations ◽  
Transport Efficiency ◽  
Multiple Chemical

The efficiency of cascade reactions, which consist of multiple chemical transformations that occur in a single step without purification steps, is limited by the transport efficiency of intermediates between adjacent...

Oleacin and oleocanthal: Two olive oil bioactives in multiple chemical forms

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
T Michel ◽  
A Termentzi ◽  
E Gikas ◽  
M Halabalaki ◽  
AB Smith ◽  
...  
Keyword(s):  
Olive Oil ◽  
Chemical Forms ◽  
Multiple Chemical

PET in patients with clear-cut multiple chemical sensitivity (MCS)

2002 ◽  
Vol 41 (06) ◽  
pp. 233-239 ◽  
Author(s):  
C. Hausteiner ◽  
A. Drzezga ◽  
P. Bartenstein ◽  
M. Schwaiger ◽  
H. Förstl ◽  
...  
Keyword(s):  
Single Photon ◽  
Photon Emission ◽  
Multiple Chemical Sensitivity ◽  
Environmental Chemicals ◽  
Chemical Sensitivity ◽  
Clear Cut ◽  
Positron Emission ◽  
Symptom Complex ◽  
Brain Changes ◽  
Multiple Chemical

SummaryAim: Multiple chemical sensitivity (MCS) is a controversially discussed symptom complex. Patients afflicted by MCS react to very low and generally nontoxic concentrations of environmental chemicals. It has been suggested that MCS leads to neurotoxic damage or neuroimmunological alteration in the brain detectable by positron emission tomography (PET) and single photon emission computer tomography (SPECT). These methods are often applied to MCS patients for diagnosis, although they never proved appropriate. Method: We scanned 12 MCS patients with PET, hypothesizing that it would reveal abnormal findings. Results: Mild glucose hypometabolism was present in one patient. In comparison with normal controls, the patient group showed no significant functional brain changes. Conclusion: This first systematic PET study in MCS patients revealed no hint of neurotoxic or neuroimmuno-logical brain changes of functional significance.

HPLC-DAD–MSnanalysis of multiple chemical constituents in a Chinese herbal preparation Shuang-Huang-Lian injection

2014 ◽  
Author(s):  
Jiayu Zhang ◽  
Qian Zhang ◽  
Ying Liu ◽  
Wei Cai ◽  
Fang Wang ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Herbal Preparation ◽  
Chinese Herbal ◽  
Multiple Chemical

BODIPY Fluorophores for Membrane Potential Imaging

2019 ◽  
Author(s):  
Jenna Franke ◽  
Benjamin Raliski ◽  
Steven Boggess ◽  
Divya Natesan ◽  
Evan Koretsky ◽  
...  
Keyword(s):  
Mammalian Cells ◽  
Water Solubility ◽  
Water Soluble ◽  
Voltage Sensitivity ◽  
Chemical Transformations ◽  
Direct Modification ◽  
Biological Compatibility ◽  
Meso Position ◽  
Ionizable Groups ◽  
Boron Center

Fluorophores based on the BODIPY scaffold are prized for their tunable excitation and emission profiles, mild syntheses, and biological compatibility. Improving the water-solubility of BODIPY dyes remains an outstanding challenge. The development of water-soluble BODIPY dyes usually involves direct modification of the BODIPY fluorophore core with ionizable groups or substitution at the boron center. While these strategies are effective for the generation of water-soluble fluorophores, they are challenging to implement when developing BODIPY-based indicators: direct modification of BODIPY core can disrupt the electronics of the dye, complicating the design of functional indicators; and substitution at the boron center often renders the resultant BODIPY incompatible with the chemical transformations required to generate fluorescent sensors. In this study, we show that BODIPYs bearing a sulfonated aromatic group at the meso position provide a general solution for water-soluble BODIPYs. We outline the route to a suite of 5 new sulfonated BODIPYs with 2,6-disubstitution patterns spanning a range of electron-donating and -withdrawing propensities. To highlight the utility of these new, sulfonated BODIPYs, we further functionalize them to access 13 new, BODIPY-based voltage-sensitive fluorophores. The most sensitive of these BODIPY VF dyes displays a 48% ΔF/F per 100 mV in mammalian cells. Two additional BODIPY VFs show good voltage sensitivity (≥24% ΔF/F) and excellent brightness in cells. These compounds can report on action potential dynamics in both mammalian neurons and human stem cell-derived cardiomyocytes. Accessing a range of substituents in the context of a water soluble BODIPY fluorophore provides opportunities to tune the electronic properties of water-soluble BODIPY dyes for functional indicators.

Strongly Coupled Redox-Linked Conformational Switching at the Active Site of the Non-Heme Iron-Dependent Dioxygenase, TauD

2019 ◽  
Author(s):  
Christopher John ◽  
Greg M. Swain ◽  
Robert P. Hausinger ◽  
Denis A. Proshlyakov
Keyword(s):  
Active Site ◽  
Structural Model ◽  
Heme Iron ◽  
Chemical Transformations ◽  
Experimental Conditions ◽  
Strongly Coupled ◽  
Non Heme Iron ◽  
Reversible Redox ◽  
Wide Range ◽  
Complex Structural

2-Oxoglutarate (2OG)-dependent dioxygenases catalyze C-H activation while performing a wide range of chemical transformations. In contrast to their heme analogues, non-heme iron centers afford greater structural flexibility with important implications for their diverse catalytic mechanisms. We characterize an <i>in situ</i> structural model of the putative transient ferric intermediate of 2OG:taurine dioxygenase (TauD) by using a combination of spectroelectrochemical and semi-empirical computational methods, demonstrating that the Fe (III/II) transition involves a substantial, fully reversible, redox-linked conformational change at the active site. This rearrangement alters the apparent redox potential of the active site between -127 mV for reduction of the ferric state and 171 mV for oxidation of the ferrous state of the 2OG-Fe-TauD complex. Structural perturbations exhibit limited sensitivity to mediator concentrations and potential pulse duration. Similar changes were observed in the Fe-TauD and taurine-2OG-Fe-TauD complexes, thus attributing the reorganization to the protein moiety rather than the cosubstrates. Redox difference infrared spectra indicate a reorganization of the protein backbone in addition to the involvement of carboxylate and histidine ligands. Quantitative modeling of the transient redox response using two alternative reaction schemes across a variety of experimental conditions strongly supports the proposal for intrinsic protein reorganization as the origin of the experimental observations.

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