Inhibitory Effects of Tea Catechins andO-Methylated Derivatives of (−)-Epigallocatechin-3-O-gallate on Mouse Type IV Allergy

2000 ◽  
Vol 48 (11) ◽  
pp. 5649-5653 ◽  
Author(s):  
Masazumi Suzuki ◽  
Kyoji Yoshino ◽  
Mari Maeda-Yamamoto ◽  
Toshio Miyase ◽  
Mitsuaki Sano
Keyword(s):  
Inhibitory Effects ◽  
Tea Catechins ◽  
Type Iv ◽  
Type Iv Allergy ◽  
Derivatives Of

Inhibitory Effects of the C-2 Epimeric Isomers of Tea Catechins on Mouse Type IV Allergy

2004 ◽  
Vol 52 (15) ◽  
pp. 4660-4663 ◽  
Author(s):  
Kyoji Yoshino ◽  
Kenjiro Ogawa ◽  
Toshio Miyase ◽  
Mitsuaki Sano
Keyword(s):  
Inhibitory Effects ◽  
Tea Catechins ◽  
Type Iv ◽  
Type Iv Allergy

Inhibitory Effects of Edible Higher Basidiomycetes Mushroom Extracts on Mouse Type IV Allergy

2002 ◽  
Vol 4 (1) ◽  
pp. 5 ◽  
Author(s):  
Mitsuaki Sano ◽  
Kyoji Yoshino ◽  
Tsunetomo Matsuzawa ◽  
Tetsuro Ikekawa
Keyword(s):  
Inhibitory Effects ◽  
Type Iv ◽  
Type Iv Allergy ◽  
Mushroom Extracts

Inhibitory Effects of Edible and Medicinal Mushroom Extract on Mouse Type IV Allergy

2001 ◽  
Vol 3 (2-3) ◽  
pp. 1
Author(s):  
Mitsuaki Sano ◽  
Kyoji Yoshino ◽  
Tsunetomo Matsuzawa ◽  
Tetsuro Ikekawa
Keyword(s):  
Medicinal Mushroom ◽  
Inhibitory Effects ◽  
Mushroom Extract ◽  
Type Iv ◽  
Type Iv Allergy

scholarly journals Inhibitory Effects of Pu-erh Tea Leaves on Mouse Type IV Allergy

2012 ◽  
Vol 03 (03) ◽  
pp. 394-400 ◽  
Author(s):  
Katsuko Yamazaki ◽  
Kyoji Yoshino ◽  
Chihiro Yagi ◽  
Toshio Miyase ◽  
Mitsuaki Sano
Keyword(s):  
Inhibitory Effects ◽  
Tea Leaves ◽  
Type Iv ◽  
Type Iv Allergy

scholarly journals Amide Derivatives of Ginkgolide B and Their Inhibitory Effects on PAF-Induced Platelet Aggregation

ACS Omega ◽  
2021 ◽  
Author(s):  
Qiang Shang ◽  
Xiaobo Zhou ◽  
Ming-Rong Yang ◽  
Jing-Guang Lu ◽  
Yu Pan ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Ginkgolide B ◽  
Inhibitory Effects ◽  
Amide Derivatives ◽  
Derivatives Of

scholarly journals Growth Inhibitory Effects of Ester Derivatives of Menahydroquinone-4, the Reduced Form of Vitamin K2(20), on All-Trans Retinoic Acid-Resistant HL60 Cell Line

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 758
Author(s):  
Hirofumi Yamakawa ◽  
Shuichi Setoguchi ◽  
Shotaro Goto ◽  
Daisuke Watase ◽  
Kazuki Terada ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Adverse Effects ◽  
Vitamin K2 ◽  
Reduced Form ◽  
Inhibitory Effects ◽  
Hl60 Cells ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Growth Inhibitory ◽  
Derivatives Of

The first-choice drug for acute promyelocytic leukemia (APL), all-trans retinoic acid (ATRA), frequently causes drug-resistance and some adverse effects. Thus, an effective and safe agent for ATRA-resistant APL is needed. Menaquinone-4 (MK-4, vitamin K2(20)), used for osteoporosis treatment, does not have serious adverse effects. It has been reported that MK-4 has growth-inhibitory effects on HL60 cells by inducing apoptosis via the activation of Bcl-2 antagonist killer 1 (BAK). However, the effect of MK-4 on ATRA-resistant APL has not been reported. Here, we show that ester derivatives of menahydroquinone-4 (MKH; a reduced form of MK-4), MKH 1,4-bis-N,N-dimethylglycinate (MKH-DMG) and MKH 1,4-bis-hemi-succinate (MKH-SUC), exerted strong growth-inhibitory effects even on ATRA-resistant HL60 (HL-60R) cells compared with ATRA and MK-4. MKH delivery after MKH-SUC treatment was higher than that after MK-4 treatment, and the results indicated apoptosis induced by BAK activation. In contrast, for MKH-DMG, reconversion to MKH was slow and apoptosis was not observed. We suggest that the ester forms, including monoesters of MKH-DMG, exhibit another mechanism independent of apoptosis. In conclusion, the MKH derivatives (MKH-SUC and MKH-DMG) inhibited not only HL60 cells but also HL-60R cells, indicating a potential to overcome ATRA resistance.

scholarly journals Alkaloid-Rich Crude Extracts, Fractions and Piperamide Alkaloids of Piper guineense Possess Promising Antibacterial Effects

Antibiotics ◽  
2018 ◽  
Vol 7 (4) ◽  
pp. 98 ◽  
Author(s):  
Eunice Mgbeahuruike ◽  
Pia Fyhrquist ◽  
Heikki Vuorela ◽  
Riitta Julkunen-Tiitto ◽  
Yvonne Holm
Keyword(s):  
Antibacterial Activity ◽  
Pathogenic Bacteria ◽  
Bacterial Resistance ◽  
Hot Water ◽  
Bacterial Strains ◽  
Inhibitory Effects ◽  
Piper Guineense ◽  
E Coli ◽  
Growth Inhibitory ◽  
Derivatives Of

Piper guineense is a food and medicinal plant commonly used to treat infectious diseases in West-African traditional medicine. In a bid to identify new antibacterial compounds due to bacterial resistance to antibiotics, twelve extracts of P. guineense fruits and leaves, obtained by sequential extraction, as well as the piperine and piperlongumine commercial compounds were evaluated for antibacterial activity against human pathogenic bacteria. HPLC-DAD and UHPLC/Q-TOF MS analysis were conducted to characterize and identify the compounds present in the extracts with promising antibacterial activity. The extracts, with the exception of the hot water decoctions and macerations, contained piperamide alkaloids as their main constituents. Piperine, dihydropiperine, piperylin, dihydropiperylin or piperlonguminine, dihydropiperlonguminine, wisanine, dihydrowisanine and derivatives of piperine and piperidine were identified in a hexane extract of the leaf. In addition, some new piperamide alkaloids were identified, such as a piperine and a piperidine alkaloid derivative and two unknown piperamide alkaloids. To the best of our knowledge, there are no piperamides reported in the literature with similar UVλ absorption maxima and masses. A piperamide alkaloid-rich hexane leaf extract recorded the lowest MIC of 19 µg/mL against Sarcina sp. and gave promising growth inhibitory effects against S. aureus and E. aerogenes as well, inhibiting the growth of both bacteria with a MIC of 78 µg/mL. Moreover, this is the first report of the antibacterial activity of P. guineense extracts against Sarcina sp. and E. aerogenes. Marked growth inhibition was also obtained for chloroform extracts of the leaves and fruits against P. aeruginosa with a MIC value of 78 µg/mL. Piperine and piperlongumine were active against E. aerogenes, S. aureus, E. coli, S. enterica, P. mirabilis and B. cereus with MIC values ranging from 39–1250 µg/mL. Notably, the water extracts, which were almost devoid of piperamide alkaloids, were not active against the bacterial strains. Our results demonstrate that P. guineense contains antibacterial alkaloids that could be relevant for the discovery of new natural antibiotics.

scholarly journals Quaternary Salts of Chitosan: History, Antimicrobial Features, and Prospects

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Douglas de Britto ◽  
Rejane Celi Goy ◽  
Sergio Paulo Campana Filho ◽  
Odilio B. G. Assis
Keyword(s):  
Physical Chemistry ◽  
Antimicrobial Activity ◽  
Drug Delivery Systems ◽  
Antimicrobial Properties ◽  
Water Soluble ◽  
Chemical Characteristics ◽  
Packaging Materials ◽  
Inhibitory Effects ◽  
Quaternary Salts ◽  
Derivatives Of

Recently, increasing attention has been paid to water-soluble derivatives of chitosan at its applications. The chemical characteristics and the antimicrobial properties of these salts can play significant role in pharmacological and food areas mainly as carriers for drug delivery systems and as antimicrobial packaging materials. In the current paper, a historical sequence of the main preparative methods, physical chemistry aspects, and antimicrobial activity of chitosan quaternized derivatives are presented and briefly discussed. In general, the results indicated that the quaternary derivatives had better inhibitory effects than the unmodified chitosan.

Inhibitory Effects of Tea Catechins on Cancer Metastasis

1997 ◽  
pp. 583-586
Author(s):  
Mari Maeda Yamamoto ◽  
Kazuhiro Osada ◽  
Yuichi Yamaguchi ◽  
Kenkou Tsuji
Keyword(s):  
Cancer Metastasis ◽  
Inhibitory Effects ◽  
Tea Catechins

Post-initiation inhibitory effects of green tea catechins on 7,12-dimethylbenz[a]anthracene-induced mammary gland carcinogenesis in female Sprague–Dawley rats

1997 ◽  
Vol 116 (1) ◽  
pp. 47-52 ◽  
Author(s):  
Hikaru Tanaka ◽  
Masao Hirose ◽  
Mayumi Kawabe ◽  
Masashi Sano ◽  
Yasuko Takesada ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Green Tea ◽  
Sprague Dawley ◽  
Inhibitory Effects ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
Sprague Dawley Rats
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