Evidence of Formation of Adenine Dimer Cation Radical in DNA: The Importance of Adenine Base Stacking

2010 ◽  
Vol 114 (16) ◽  
pp. 5600-5604 ◽  
Author(s):  
Kazuo Kobayashi
Keyword(s):  
Cation Radical ◽  
Base Stacking ◽  
Adenine Base

scholarly journals Effect of Base Stacking on the Acid−Base Properties of the Adenine Cation Radical [A•+] in Solution: ESR and DFT Studies

2008 ◽  
Vol 130 (31) ◽  
pp. 10282-10292 ◽  
Author(s):  
Amitava Adhikary ◽  
Anil Kumar ◽  
Deepti Khanduri ◽  
Michael D. Sevilla
Keyword(s):  
Cation Radical ◽  
Dft Studies ◽  
Base Stacking ◽  
Acid Base ◽  
Base Properties

Anomalous Base-Stacking of the N1-Oxide of AMP

1977 ◽  
Vol 32 (11-12) ◽  
pp. 901-904 ◽  
Author(s):  
H. H. Mantsch ◽  
O. Bârzu
Keyword(s):  
Aqueous Solution ◽  
Chemical Shifts ◽  
Base Stacking ◽  
Receptor Molecule ◽  
H Nmr ◽  
Nucleotide Analog ◽  
Stacking Pattern ◽  
Intermolecular Association ◽  
The Individual ◽  
Adenine Base

Abstract The intermolecular association in aqueous solution of the N1-oxide nucleotide analog of adenosine-5′-monophosphate has been investigated by 1H-NMR spectroscopy over the concentration range 0.0006-0.6 ᴍ. The concentration profile of individual chemical shifts provides evidence for an unusual stacking pattern compared to that of the natural nucleotide AMP, involving only the imidazole moiety of the adenine base. The different stacking pattern of this nucleotide analog suggests that the exact stacking geometry of natural nucleotides interacting with nucleotide-depending enzymes, is achieved by adjusting to the geometry of the individual receptor molecule.

NADH in Solution: A Single State

2019 ◽  
Author(s):  
Joachim Hönes ◽  
Julia Wack ◽  
Katja Schmitz
Keyword(s):  
Aqueous Solution ◽  
Base Stacking ◽  
Spectroscopic Evidence ◽  
Single State

<div>Spectroscopic evidence is presented to show that NADH in aqueous solution does not exist as a folded/unfolded equilibrium but as a single state. The molecule is folded but without base stacking between dihydronicotinamide and adenine.<br></div>

Conducting Cation-Radical Salts Bedt-TTF with Metal Complex Anions

1991 ◽  
Vol 62-64 ◽  
pp. 513-514
Author(s):  
N.D. Kushch ◽  
A.A. Ignatiev ◽  
V.N. Laukhin ◽  
M.K. Makova ◽  
V.A. Merzhanov ◽  
...  
Keyword(s):  
Metal Complex ◽  
Cation Radical ◽  
Complex Anions

scholarly journals Structure-guided engineering of adenine base editor with minimized RNA off-targeting activity

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Jianan Li ◽  
Wenxia Yu ◽  
Shisheng Huang ◽  
Susu Wu ◽  
Liping Li ◽  
...  
Keyword(s):  
Rna Editing ◽  
Potential Interaction ◽  
Reporter System ◽  
Independent Manner ◽  
Robust Detection ◽  
Guide Rna ◽  
Highly Efficient ◽  
Adenine Base

AbstractBoth adenine base editors (ABEs) and cytosine base editors (CBEs) have been recently revealed to induce transcriptome-wide RNA off-target editing in a guide RNA-independent manner. Here we construct a reporter system containing E.coli Hokb gene with a tRNA-like motif for robust detection of RNA editing activities as the optimized ABE, ABEmax, induces highly efficient A-to-I (inosine) editing within an E.coli tRNA-like structure. Then, we design mutations to disrupt the potential interaction between TadA and tRNAs in structure-guided principles and find that Arginine 153 (R153) within TadA is essential for deaminating RNAs with core tRNA-like structures. Two ABEmax or mini ABEmax variants (TadA* fused with Cas9n) with deletion of R153 within TadA and/or TadA* (named as del153/del153* and mini del153) are successfully engineered, showing minimized RNA off-targeting, but comparable DNA on-targeting activities. Moreover, R153 deletion in recently reported ABE8e or ABE8s can also largely reduce their RNA off-targeting activities. Taken together, we develop a strategy to generate engineered ABEs (eABEs) with minimized RNA off-targeting activities.

Application of Trajectory Surface Hopping to the Study of a Symmetry-Forbidden Intramolecular Hole Transfer Process in Bismethyleneadamantane Cation Radical

1999 ◽  
Vol 121 (48) ◽  
pp. 11171-11178 ◽  
Author(s):  
Garth A. Jones ◽  
Barry K. Carpenter ◽  
Michael N. Paddon-Row
Keyword(s):  
Transfer Process ◽  
Cation Radical ◽  
Hole Transfer ◽  
Surface Hopping
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