Development of a Continuous Plug Flow Process for Preparation of a Key Intermediate for Brivanib Alaninate

Nowadays, the Industry 4.0 concept affects every area of the industrial, economic, social and personal sectors. The most significant changings are the automation and the digitalization. This is also true for the material handling processes, where the handling systems use more and more automated machines; planning, operation and optimization of different logistic processes are based on many digital data collected from the material flow process. However, new methods and devices require new solutions which define new research directions. In this paper we describe the state of the art of the material handling researches and draw the role of the UMi-TWINN partner institutes in these fields. As a result of this H2020 EU project, scientific excellence of the University of Miskolc can be increased and new research activities will be started.

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HEAT TRANSFER ENHANCEMENT USING FERROFLUIDIC PLUG FLOW IN MICROCHANNELS

10.1615/ihtc16.hte.022833 ◽

2018 ◽

Author(s):

Nicolette Gan Jia Gui ◽

Cameron Stanley ◽

Gary Rosengarten

Keyword(s):

Heat Transfer ◽

Heat Transfer Enhancement ◽

Plug Flow ◽

Transfer Enhancement

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Parameters Measurement for Multiphase Flow Process

ACTA AUTOMATICA SINICA ◽

10.3724/sp.j.1004.2013.01923 ◽

2013 ◽

Vol 39 (11) ◽

pp. 1923 ◽

Cited By ~ 6

Author(s):

Chao TAN ◽

Feng DONG

Keyword(s):

Multiphase Flow ◽

Flow Process ◽

Parameters Measurement

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Diffuser Efficiency and Flow Process of Supersonic Wind Tunnels with Free Jet Test Section

10.21236/ada377566 ◽

1950 ◽

Cited By ~ 2

Author(s):

Rudolf Hermann

Keyword(s):

Test Section ◽

Wind Tunnels ◽

Flow Process ◽

Free Jet

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Frequency-Response Approach to Modelling Continuous Reactors

Water Quality Research Journal ◽

10.2166/wqrj.1971.015 ◽

1971 ◽

Vol 6 (1) ◽

pp. 249-272

Author(s):

P.B. Melynk ◽

J.D. Norman ◽

A.W. Wilson

Keyword(s):

Frequency Response ◽

Flow Model ◽

Plug Flow ◽

Order Reaction ◽

Parameter Estimates ◽

Second Order Reaction ◽

Mixing Conditions ◽

Bode Plot ◽

Flow Through ◽

Search Routine

Abstract It is postulated that the mixing conditions in a flow-through reactor can be characterized as having either completely mixed, completely plug flow, or some network of completely mixed and plug flow component vessels. A frequency-response technique is used to obtain an experimental Bodé plot for arbitrarily mixed vessels. The interpretation of the Bodé plot is discussed, and , in light of this interpretation, a network of plug flow and completely mixed components is specified as a flow model. A Rosenbrock search routine is used to improve the parameter estimates of the model. To verify the model, a second order reaction was run through the vessel and the experimentally measured conversion was compared to that predicted by the model. It is shown that the modeling technique, in addition to describing the mixing in the system, will indicate inactive volume, as well as measure the extent of any channeling or short circuiting in the reactor.

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Steady State Measurement of Oxygenation Capacity

Water Science & Technology ◽

10.2166/wst.1985.0139 ◽

1985 ◽

Vol 17 (2-3) ◽

pp. 303-311

Author(s):

Kees de Korte ◽

Peter Smits

Keyword(s):

Steady State ◽

Activated Sludge ◽

Plug Flow ◽

Usual Method ◽

Steady State Method ◽

State Measurement ◽

Flow Systems ◽

Air System ◽

State Method ◽

Steady State Measurement

The usual method for OC measurement is the non-steady state method (reaeration) in tapwater or, sometimes, in activated sludge. Both methods are more or less difficult and expensive. The steady state method with activated sludge is presented. Fundamentals are discussed. For complete mixed aeration tanks, plug flow systems with diffused air aeration and carousels the method is described more in detail and the results of measurements are presented. The results of the steady state measurements of the diffused air system are compared with those of the reaeration method in tapwater. The accuracy of the measurements in the 3 systems is discussed. Measurements in other aeration systems are described briefly. It is concluded that the steady state OC measurement offers advantages in comparison with the non-steady state method and is useful for most purposes.

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Sprat – A Simple River Quality Impact Model for Intermittent Discharges

Water Science & Technology ◽

10.2166/wst.1989.0171 ◽

1989 ◽

Vol 21 (12) ◽

pp. 1793-1796

Author(s):

C. P. Crockett ◽

R. W. Crabtree ◽

H. R. Markland

Keyword(s):

Plug Flow ◽

River System ◽

Response Assessment ◽

River Basin Management ◽

Impact Model ◽

Basin Management ◽

Potential Accuracy ◽

North West ◽

River Quality ◽

Receiving Waters

The detrimental influence of storm sewer overflows on urban river quality has been widely recognised for many years. One objective of the WRc River Basin Management programme is the development of a river impact model capable of predicting the transient quality changes in receiving waters due to intermittent storm sewage discharges. The production of SPRAT (Spill Pollution Response Assessment Technique) is the first step in the development of such a model. SPRAT incorporates a number of significant simplifications, most notably plug flow and instantaneous mixing, and does not implicitly take into account the effects of dispersion. These simplifications reflect the large errors associated with the model inputs. These errors severely limit the potential accuracy of any river impact model. The model has been applied to the Bolton river system in North West England. The development and application of SPRAT has enabled the requirements for a more sophisticated river quality impact model to be clearly defined, in addition to highlighting the problems associated with gathering suitable data with which to build and calibrate such a model.

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Tertiary nitrification in pilot-plant plug-flow fixed-film reactors with long-term ammonium deficiency

Water Science & Technology ◽

10.2166/wst.1994.0746 ◽

1994 ◽

Vol 29 (10-11) ◽

pp. 61-67 ◽

Cited By ~ 2

Author(s):

M. Fruhen ◽

K. Böcker ◽

S. Eidens ◽

D. Haaf ◽

M. Liebeskind ◽

...

Keyword(s):

Pilot Plant ◽

Effective Means ◽

Plug Flow ◽

Nitrification Rate ◽

Industrial Project ◽

Transfer Processes ◽

Fixed Film ◽

Film Reactor ◽

Observation Period

The objective of this study is to investigate to what extent the nitrification capacity of a pilot-plant fixed-film reactor changes during extensive periods of nutrient supply deficiency. The examined pilot-plant was an upflow reactor filled with swelling clay of medium grain size (6 to 8 mm). The experiments revealed that the maximum nitrification rate remained practically constant during the first weeks after the onset of unregulated ammonium supply. The capacity declined slowly, dropping to approximately 66% of the initial capacity after about ten weeks. Still ammonium peaks of up to 8 mg/l were readily nitrified throughout the entire period of the experiment. The reduction in nitrification capacity during the observation period did not result from decay processes of biomass but from the reactor becoming blocked and thus hampering transfer processes. It could be observed that the detached organisms attached again further up. This semi-industrial project demonstrated that a plug-flow fixed-film reactor can be used as effective means of tertiary nitrification.

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