Complex Compounds of Glycyrrhizic Acid with Antimicrobial Drugs

2003 ◽  
Vol 37 (9) ◽  
pp. 485-488 ◽  
Author(s):  
R. M. Kondratenko ◽  
L. A. Baltina ◽  
S. R. Mustafina ◽  
A. F. Ismagilova ◽  
F. S. Zarudii ◽  
...  
Keyword(s):  
Glycyrrhizic Acid ◽  
Complex Compounds ◽  
Antimicrobial Drugs

scholarly journals COMPLEX COMPOUNDS BASED ON PINOSTROBIN OXIME

2021 ◽  
pp. 219-226
Author(s):  
Sergazy Mynzhasarovich Adekenov ◽  
Gabiden Maratovich Baysarov ◽  
Anar Nikhanbaevna Zhabayeva ◽  
Lyubov' Petrovna Suntsova ◽  
Aleksandr Valer'yevich Dushkin
Keyword(s):  
Intermolecular Interaction ◽  
Glycyrrhizic Acid ◽  
Water Solubility ◽  
Solid Dispersions ◽  
Magnesium Carbonate ◽  
Complex Compounds ◽  
Disodium Salt ◽  
Mechanochemical Treatment ◽  
Melting Peak ◽  
Scanning Calorimetry

The article studied the structural features of solid dispersions of pinostrobin oxime with arabinogalactan, disodium salt of glycyrrhizic acid, polyvinylpyrrolidone and basic magnesium carbonate obtained by mechanochemical treatment. The obtained complexes of pinostrobin oxime with arabinogalactan, disodium salt of glycyrrhizic acid, polyvinylpyrrolidone, and basic magnesium carbonate have increased water solubility in comparison with the initial pinostrobin oxime. The thermal effects of pinostrobin oxime and its complex compounds have been studied by differential scanning calorimetry. At the same time, on the DSC-curve, the melting peak of solid dispersions of pinostrobin oxime with disodium salt of glycyrrhizated acid and pinostrobin oxime with arabinogalactan is not displayed, which is associated with the intermolecular interaction of the components of the complex, where the molecule of pinostrobin oxime forms a bond with a complexformation agent during mechanochemical treatment. The complex of pinostrobin oxime with magnesium carbonate is not formed, as evidenced by the thermal curve, where the melting of the sample begins at 182 °C, and complete destruction occurs at a temperature of 782 °C, which is similar to the melting peak of the initial pinostrobin oxime. The results of studying intermolecular bonds in complexes of pinostrobin oxime by the method of NMR-relaxation indicate that the times of spin-lattice and spin-spin relaxation are very sensitive to intermolecular interaction and to the diffusion mobility of molecules.

scholarly journals Water-Soluble Substances of Arglabin

2020 ◽  
Vol 22 (3) ◽  
pp. 205
Author(s):  
S.M. Adekenov ◽  
А.N. Zhabayeva ◽  
G.М. Baisarov
Keyword(s):  
Complex Formation ◽  
Sesquiterpene Lactone ◽  
Glycyrrhizic Acid ◽  
Water Solubility ◽  
Magnesium Carbonate ◽  
Complex Compounds ◽  
Disodium Salt ◽  
Water Soluble ◽  
Mechanochemical Treatment ◽  
Complexing Agents

The article discusses the results of a study of the water solubility of natural sesquiterpene lactone arglabin, in particular, its ability to complex formation with complexing agents polyvinylpyrrolidone, the disodium salt of glycyrrhizic acid, magnesium carbonate. Mechanocomposites with polyvinylpyrrolidone and disodium salt of glycyrrhizic acid, which have increased water solubility, were obtained by the method of mechanochemical treatment of arglabin native. At the same time, the best result of dissolution in water is achieved by a two-hour treatment with polyvinylpyrrolidone and with disodium salt of glycyrrhizic acid. The water solubility of complex compounds of arglabin with polyvinylpyrrolidone increases by 4.61 times, and with disodium salt of glycyrrhizic acid by 4.42 times.

scholarly journals MOLECULAR COMPLEXES OF MONOAMMONIUM SALT OF GLYCYRRHIZIC ACID WITH SOME UREA AND THEIR ANTIBIOTIC ACTIVITY

2021 ◽  
Vol 19 (3) ◽  
pp. 160-167
Author(s):  
Yu.T. Isaev ◽  
◽  
I.R. Askarov ◽  
S.A. Rustamov ◽  
D.U. Egamberdiev ◽  
...  
Keyword(s):  
Glycyrrhizic Acid ◽  
Fungicidal Activity ◽  
Pathogenic Fungus ◽  
Equilibrium Constants ◽  
Molecular Complexes ◽  
Complex Compounds ◽  
Antibiotic Activity ◽  
Polar Groups ◽  
Ir Spectroscopic ◽  
Complexation Process

This article reports on obtaining the inclusion compounds of the monoammonium-glycyrrhizin salts with urea, thiourea and methylolthiourea. The compounds were obtained by the liquid phase way, and their structures were characterized by the UV- and IR-Spectroscopic methods. Proceeding from the spectral data, it was concluded that the complexation occurs through the interaction of polar groups of the components. The composition of the complexes was studied using the method of isomolar series. Equilibrium constants and changes in Gibbs free energy of the complexation process were also calculated. The biological activity of complex compounds was studied on the example of fungicidal activity of one of the most common pathogenic fungus Fusarium. The obtained compounds can be used as as fungicides and stimulants in agriculture.

Diagnosis of helicobacter pylori infection: problems and prospects

2020 ◽  
pp. 54-59
Author(s):  
A. S. Molostova ◽  
N. S. Gladyshev ◽  
A. V. Svarval ◽  
R. S. Ferman ◽  
A. B. Karasyova ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Urease Activity ◽  
Diagnostic Methods ◽  
Study Group ◽  
Biochemical Method ◽  
Antimicrobial Drugs ◽  
Non Invasive ◽  
Number Of Patients ◽  
Pcr Method ◽  
Positive Results

(HP) infection was performed using invasive and non-invasive methods. The study group consisted of 95 patients with dyspepsia. HP infection was detected in 47 patients (49.4 %). The expediency of using a set of diagnostic methods for detecting HP (PCR, immunochromatographic, bacteriological and method for determining urease activity) is proved. Most often (100 %) in patients HP infection was detected in biopsies using the PCR method. Somewhat less frequently it was detected when examining biopsies with an invasive biochemical method (AMA RUT Reader) (82 %) and fecal immunochromatographic method (83 %). Despite the fact that helicobacteriosis was detected bacteriologically in a small number of patients (24 %), this method is of particular value, since it allows you to assess the sensitivity to antimicrobial drugs and probiotics, and does not give false positive results.

Benzothiazole moieties and their derivatives as antimicrobial and antiviral agents: A mini-review

2020 ◽  
Vol 11 (3) ◽  
pp. 3309-3315
Author(s):  
Manahil B Elamin ◽  
Amani Abd Elrazig Salman Abd Elaziz ◽  
Emad Mohamed Abdallah
Keyword(s):  
Scientific Literature ◽  
Antiviral Agents ◽  
Antiviral Drug ◽  
Pharmaceutical Chemistry ◽  
Heterocyclic Chemistry ◽  
Antimicrobial Drugs ◽  
Benzothiazole Derivatives ◽  
Global Concern ◽  
Pharmaceutical Molecules ◽  
Heterocyclic Moiety

Heterocyclic chemistry has provided an inexhaustible source of pharmaceutical molecules. Heterocyclic compounds such as benzothiazole moieties and its derivatives area substantial class of compounds in pharmaceutical chemistry and exhibited therapeutic capabilities, such as antitumor, anticancer, antioxidant, antidiabetic, antiviral, antimicrobial, antimalarial, anthelmintic and other activities. Besides, some antibiotics such as penicillin and cephalosporin have heterocyclic moiety. The growing prevalence of multi-drug resistant pathogens represents serious global concern,which requires the development of new antimicrobial drugs. Moreover, the emergence of pandemic SARSCoV-2 causing Covid-19 disease and all these health dilemmas urge the scientific community to examine the possible antimicrobial and antiviral capacities of some bioactive benzothiazole derivatives against these severe causative agents.This mini-review highlights some recent scientific literature on different benzothiazole molecules and their derivatives. It turns out that, there are numerous synthesized benzothiazole derivatives which exhibited different mode of actions against microorganisms or viruses and accordingly suggested them as an active candidate in the discovery of new antimicrobial or antiviral agents for clinical development. The recommended bioactive benzothiazole derivatives mentioned in the current study are mainly Schiff bases, azo dyes and metal complexes benzothiazole derivatives; the starting material for most of these derivatives are 2-aminobenzothiazole although careful pharmaceutical studies should be conducted to ensure the safety and efficacy of these bioactive synthesized molecules as an antimicrobial or antiviral drug in the future.

METHYLETHYLPYRIDINOL SUCCINATE AS POTENTIAL ADJUVANT OF ANTIMICROBIAL DRUGS

2018 ◽  
Vol 14 (64) ◽  
pp. 123
Author(s):  
E. M. Vazhnycha ◽  
G. A. Loban ◽  
N. A. Bobrova ◽  
O. V. Gancho
Keyword(s):  
Antimicrobial Drugs

STUDY ON NEW COMPLEX COMPOUNDS OF Ti(IV) AND Zr(IV) IN AQUEOUS SOLUTIONS: SYNTHESIS, STABILITY AND APPLICATION IN CLEANER TECHNOLOGIES OF NATURAL LEATHER

2008 ◽  
Vol 7 (3) ◽  
pp. 241-248 ◽  
Author(s):  
Doina Sibiescu ◽  
Ioan Rosca ◽  
Daniel Sutiman ◽  
Marian Crudu ◽  
Adrian Cailean ◽  
...  
Keyword(s):  
Aqueous Solutions ◽  
Complex Compounds ◽  
Cleaner Technologies
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