Vitamin D Daily short-term Supplementation does not Affect Glycemic Outcomes of Patients with Type 2 Diabetes

2016 ◽  
Vol 86 (5-6) ◽  
pp. 169-183 ◽  
Author(s):  
Stavri Chrysostomou
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Vitamin D Supplementation ◽  
Inverse Association ◽  
Glycemic Status ◽  
Positive Effects ◽  
Vitamin D Levels ◽  
Glycemic Outcomes ◽  
The Impact

There is currently insufficient evidence of a beneficial effect to recommend vitamin D supplementation for optimizing glycemic status in patients with type 2 diabetes mellitus (T2DM). Taking into consideration the significant extra-skeletal effect of vitamin D on pancreatic β-cell function and insulin secretion and the large number of scientific evidence supporting the inverse association between vitamin D status and hyperglycemia, this review article aims to examine whether vitamin D supplementation therapies are beneficial to patients with T2DM considering specific factors through randomized controlled trials (RCTs). EBSCOhost and Medline databases were searched from the beginning of 2009 until the end of 2014 for RCTs in patients with T2DM. Parameters, such as baseline vitamin D levels, frequency/dosage of supplementation, length of the study and type of supplementation, were independently assessed, based on their effect on glycemic status. Although all different types of supplementation were safe and effective in the achievement of vitamin D sufficiency in a dose-dependent way, the impact on glycemic status was different. 14 RCTs were included with daily supplementations ranging from 400-11.200 IU/daily, 40.000-50.000 IU/weekly and 100.000-300.000 IU/intramuscularly or once given, for a period from 8 to 24 weeks. Daily supplementation of vitamin D (up to 11.200 IU) showed no effect, whereas combined supplementation, with calcium (≥300 mg), and with vitamin D doses similar to the RDA, showed positive effects. Additionally, high weekly doses of vitamin D (40.000-50.000 IU) were effective on glycemic outcomes but available data are limited.

scholarly journals VITAMIN D SUPPLEMENTATION AND HBA1C LEVELS IN TYPE 2 DIABETIC PATIENTS

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Mahesh Kumar Singh
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Vitamin D Supplementation ◽  
Diabetic Patients ◽  
Inverse Association ◽  
Natural Diet ◽  
Vitamin D Levels ◽  
Tertiary Center ◽  
Hba1c Levels

Introduction: Type 2 diabetes mellitus (T2DM) is a major public health problem, with an estimated 65 million patients in India. Studies shown that low serum 25(OH)D concentrations are associated with an increased risk of type 2 diabetes and shown the beneficial effect of vitamin D supplementation on insulin sensitivity. Vitamin D is formed in humans by subcutaneous photosynthesis from its precursor, 7-dehydrocholesterol by exposing themselves to the sun. older age is associated with a decrease in 7-dehydrocholesterol concentration in the human skin. This lifestyle habit and their natural diet of low vitamin D consumption may cause poor glucose control in diabetic patients. The purpose of this study was to examine the association between serum 25(OH)D and glycosylated hemoglobin (HbA1c) levels. Material and Methods: This was a prospective observational study of T2DM patients aged 18 and above who attended the outpatient clinics of a tertiary center. The following variables were collected from the cases: age, sex, type of diabetes, HbA1c result. Baseline HbA1c and vitamin D levels were recorded prior to supplementation and after a period of 6 months of supplementation with vitamin D, HbA1c and vitamin D levels were recorded once again.  Results: A total of 169 patients were included in the study and whose follow up was completed at the end of 6 months. Mean age of the study population was 46.87 ± 15.99. there were 74(43.79%) male and 95(56.21%) female.  Mean HbA1c pre-supplementation (%) was   9.58 ± 2.41 while post supplementation was 7.21 ± 1.08. There was a significant reduction of HbA1c of T2DM (P < 0.0001). Vitamin D levels pre-supplementation (nmol/L) (mean ± SD) was 38.54 ± 29.54 while, Vitamin D levels post-supplementation (nmol/L) (mean ± SD) was 38.54  ± 29.54. There was a significant increase of vitamin D levels of T2DM (P < 0.0001). Conclusion: Significant inverse association between vitamin levels D and HbA1c in T2DM patients was observed. Also there was significant reduction in HbA1c as vitamin D levels increased. Regular screening of vitamin levels D and HbA1c in T2DM patients is advised. Keywords: Vitamin D, diabetes, T2DM, 25-hydroxyvitamin D

Association of genetic polymorphisms in vitamin D receptor (ApaI, TaqI and FokI) with vitamin D and glycemic status in type 2 diabetes patients from Southern India

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Sandhiya Selvarajan ◽  
Akila Srinivasan ◽  
Deepanjali Surendran ◽  
Jayanthi Mathaiyan ◽  
Sadishkumar Kamalanathan
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Southern India ◽  
Glycemic Status ◽  
Genotype Frequencies ◽  
South Indian ◽  
Vitamin D Levels ◽  
Vdr Polymorphisms ◽  
Diabetes Patients

Abstract Objectives To evaluate the association of VDR polymorphisms (FokI, TaqI and ApaI) with vitamin D levels and glycemic status in type 2 diabetes patients from Southern India. Methods In this observational study, genotype frequencies and vitamin D levels of 200 cases (type 2 diabetes patients) were compared with 300 controls (unrelated anonymised stored samples of healthy volunteers) from south India. Serum 25 (OH) D levels were measured by immunoassay technique, glycated hemoglobin (HbA1c) was measured using HPLC and genotyping of VDR polymorphisms were carried out using Real time Polymerase Chain Reaction (RT PCR). Results About 69.2% of type 2 diabetes patients were found to have vitamin D deficiency. FokI polymorphism showed variations in serum 25 (OH) D levels, with AA and AG genotypes having significantly lower serum 25 (OH) D levels as compared to GG [13.24 (8.4) ng/ml, 15.02 (7.07) ng/ml and 20.67 (13.64) ng/ml respectively]. There was no difference in HbA1c levels with respect to the vitamin D levels and VDR polymorphisms. Conclusions AA and AG genotypes of FokI polymorphisms are associated with low serum 25 (OH) D levels. However there was no association between VDR polymorphisms and glycemic status in south Indian type 2 diabetes patients.

scholarly journals Prospective Evaluation of Vitamin D Supplementation on Peripheral Neuropathy in Type 2 Diabetes Mellitus -A Review

2021 ◽  
pp. 260-266
Author(s):  
Faisal Suliman Algaows ◽  
Fatema Abdullah Althkerallah ◽  
Norah Abdulmohsen Alsuwailem ◽  
Amnah Abdulnasser Mawlan Ahmed ◽  
Razan Fahad Alwagdani ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Peripheral Neuropathy ◽  
Vitamin D Insufficiency ◽  
Vitamin D Supplementation ◽  
Vitamin D Levels

Diabetic neuropathy is a long-term consequence of diabetes that can cause significant morbidity and a decline in quality of life in many individuals. Low vitamin D levels, in addition to causing rickets in infants and chondrosteoma in adults, may have a role in the development of DM and its underlying disorders, according to a growing body of evidence. Vitamin D deficiency has been linked to type 1 or type 2 diabetes, as well as the microvascular and macrovascular problems that come with it. Vitamin D insufficiency has been linked to diabetic peripheral neuropathy (DPN) as an independent risk factor. Vitamin D, both topical and oral, has been shown to considerably improve DPN symptoms and pain.

The impact of vitamin D levels on glycemic control and bone mineral density in postmenopausal women with type 2 diabetes

2015 ◽  
Vol 38 (12) ◽  
pp. 1365-1372 ◽  
Author(s):  
I. Perez-Diaz ◽  
G. Sebastian-Barajas ◽  
Z. G. Hernandez-Flores ◽  
R. Rivera-Moscoso ◽  
H. K. Osorio-Landa ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Glycemic Control ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Mineral Density ◽  
Vitamin D Levels ◽  
The Impact

scholarly journals Hypovitaminosis D and effect of vitamin D supplementation in type 2 diabetes mellitus: a rural population based study

2019 ◽  
Vol 6 (4) ◽  
pp. 1293
Author(s):  
Sathiyanarayanan Janakiraman ◽  
Girija Subramanian
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Vitamin D Supplementation ◽  
Vitamin D Levels ◽  
Short Period ◽  
Before And After ◽  
The Mean

Background: Deficiency of Vitamin D in general population and its association with various disease conditions have been studied worldwide. Type 2 Diabetes mellitus is increasing at an alarming rate in Indian subcontinent, contributing to increased morbidity and mortality. This study aimed to estimate level of Vitamin D and its association with patients with type 2 diabetes mellitus of rural origin. This study objective was to estimate the Vitamin D level of patients with Type 2 Diabetes mellitus and the effect of Vitamin D supplementation on glycemic statusMethods: This study was conducted at the Department of General medicine for a period of 1 year. Eighty patients with type 2 Diabetes mellitus were recruited in the study and baseline parameters of glycemic control and Vitamin D levels were assessed. Only 36 patients complied with the recommendation and evaluated further.Results: All the patients included in the study had insufficient or deficient levels of Vitamin D. The mean vitamin D levels before and after supplementation were 17.75±6.30 and 29.33±6.34 respectively. The mean plasma HbA1c level before and after supplementation were 7.78 and 7.30 respectively. Patients after vitamin D replacement showed significant improvement in their glycaemic status.Conclusions: Vitamin D supplementation of 2000 IU/day had shown to improve the glycaemic status. The beneficial effect of Vitamin D on diabetes was evident in a short period of supplementation.

Association of genetic polymorphisms in vitamin D receptor (ApaI, TaqI and FokI) with vitamin D and glycemic status in type 2 diabetes patients from Southern India

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Sandhiya Selvarajan ◽  
Akila Srinivasan ◽  
Deepanjali Surendran ◽  
Jayanthi Mathaiyan ◽  
Sadishkumar Kamalanathan
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Southern India ◽  
Glycemic Status ◽  
Genotype Frequencies ◽  
South Indian ◽  
Vitamin D Levels ◽  
Vdr Polymorphisms ◽  
Diabetes Patients

Abstract Objectives To evaluate the association of VDR polymorphisms (FokI, TaqI and ApaI) with vitamin D levels and glycemic status in type 2 diabetes patients from Southern India. Methods In this observational study, genotype frequencies and vitamin D levels of 200 cases (type 2 diabetes patients) were compared with 300 controls (unrelated anonymised stored samples of healthy volunteers) from south India. Serum 25 (OH) D levels were measured by immunoassay technique, glycated hemoglobin (HbA1c) was measured using HPLC and genotyping of VDR polymorphisms were carried out using Real time Polymerase Chain Reaction (RT PCR). Results About 69.2% of type 2 diabetes patients were found to have vitamin D deficiency. FokI polymorphism showed variations in serum 25 (OH) D levels, with AA and AG genotypes having significantly lower serum 25 (OH) D levels as compared to GG [13.24 (8.4) ng/ml, 15.02 (7.07) ng/ml and 20.67 (13.64) ng/ml respectively]. There was no difference in HbA1c levels with respect to the vitamin D levels and VDR polymorphisms. Conclusions AA and AG genotypes of FokI polymorphisms are associated with low serum 25 (OH) D levels. However there was no association between VDR polymorphisms and glycemic status in south Indian type 2 diabetes patients.

scholarly journals Study on the correlation between Vitamin D and HbA1c in type 2 diabetes mellitus

2021 ◽  
Vol 9 (4) ◽  
pp. 219-224
Author(s):  
Dr. A Ponnambalam ◽  
◽  
Dr. M Arun ◽  
Dr. G. Prabhu ◽  
◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Hypovitaminosis D ◽  
Vitamin D Supplementation ◽  
Type 2 Dm ◽  
Vitamin D Levels

Background: Type 2 diabetes mellitus (DM) is associated with increased morbidity and mortalitydue to the development of complications, especially due to poor glycemic control. Besides its role incalcium homeostasis, Vitamin D has been involved in the pathophysiology as well as glycemiccontrol of type 2 DM. Methods: 100 patients diagnosed with type 2 DM were included. Vitamin Dlevels along with glycosylated haemoglobin were measured in all the individuals. Results: Vitamin Ddeficiency was observed in 48% of the patients. Vitamin D levels were not associated with markersof glycemic control (HbA1c). Conclusions: Hypovitaminosis D was observed nearly in half of thepatients with type 2 diabetes, suggesting a potential for vitamin D supplementation in type 2 DMpatients.

scholarly journals Effects of 12 Months of Vitamin D Supplementation on Physical Fitness Levels in Postmenopausal Women with Type 2 Diabetes

2021 ◽  
Vol 6 (4) ◽  
pp. 87
Author(s):  
Claudio Melibeu Bentes ◽  
Pablo B. Costa ◽  
Monique Resende ◽  
Claudia Netto ◽  
Ingrid Dias ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Physical Fitness ◽  
Postmenopausal Women ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Physical Tests

Introduction: It is common for postmenopausal women to receive a vitamin D supplementation prescription to assist in preventing future falls and to maintain bone health. However, the association between vitamin D supplementation and physical fitness components has not been studied in older women with diabetes. Objective: We examined the influence of 12 months of vitamin D supplementation on the components of physical fitness in postmenopausal women with type 2 diabetes mellitus (T2DM). Methods: Thirty-five postmenopausal women (62.48 ± 7.67 years; 154.6 ± 5.11 cm; 73.93 ± 15.43 kg; 31.13 ± 5.82 BMI) with a diagnosis of T2DM participated in this longitudinal study where participants were supplemented with 1000 IU/day of vitamin D over 12 months. Subjects performed fasting blood samples, anthropometric assessments, body composition, clinical exams, and physical tests at 6-month intervals (P0, P6, and P12). Results and Conclusion: Vitamin D supplementation alone was effective in postmenopausal women in increasing serum vitamin D levels, altering muscle strength levels, promoting improvements in muscle function, as well as preventing and controlling fragility caused by T2DM and aging.

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