Vorgeburtlicher Androgen- einfluss auf süchtiges Verhalten in                     der Adoleszenz

Zusammenfassung. Hintergrund: Im Vergleich zu Frauen konsumieren Männer häufiger Alkohol, Tabak sowie illegale Drogen und sind anfälliger für pathologisches Glücksspiel und süchtiges Internetspielen. Die genannten Geschlechtsunterschiede deuten sich bereits im Adoleszentenalter an. Entsprechendes Konsumverhalten steht mit externalisierenden Auffälligkeiten der Jugendlichen in Zusammenhang. Neben sozialen Einflussfaktoren spielen biologische Faktoren eine zentrale Rolle für die Entstehung dieser Geschlechtsunterschiede. Bereits pränatal beeinflussen Androgene und Östrogene die Entwicklung des Gehirns mit bis ins Erwachsenenalter anhaltenden funktionellen und strukturellen Effekten. Intrauterine Sexualhormonexposition ist mit mütterlichen Risikofaktoren wie Stress und Substanzkonsum assoziiert. Ziel: Diese narrative Übersichtsarbeit diskutiert, welche Bedeutung vorgeburtlicher Androgeneinfluss im Mutterleib für die Entwicklung von süchtigem Verhalten und Selbstregulation im späteren Leben haben könnte. Zu diesem Thema wurden in den letzten Jahren tierexperimentelle Untersuchungen mit direkter Modulation pränataler Androgenisierung und klinische assoziative Studien basierend auf Biomarkern wie dem Zeige-/Ringfingerlängenverhältnis (2D:4D) durchgeführt. Ergebnis: Die aktuelle Studienlage lässt vermuten, dass eine verstärkte Androgenisierung des Gehirns während der intrauterinen Entwicklung das Risiko für süchtiges Verhalten und Selbstregulationsdefizite im späteren Leben erhöht. Abschließend werden Präventionsmöglichkeiten in der Schwangerschaft basierend auf diesem Modell diskutiert und ein kurzer Einblick in die Maternal Health and Infant Development in the Follow-up after Pregnancy and a Mindfulness Intervention Studie gegeben. Diese ist ein Teilprojekt des IMAC-Mind Forschungsverbundes zur Verbesserung der psychischen Gesundheit und zur Verringerung der Suchtgefahr im Kindes- und Jugendalter durch Achtsamkeit.

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Diffusion of Handwashing Knowledge and Water Treatment Practices From Mothers in an Antenatal Hygiene Promotion Program to Nonpregnant Friends and Relatives, Machinga District, Malawi

International Quarterly of Community Health Education ◽

10.1177/0272684x18797063 ◽

2018 ◽

Vol 39 (1) ◽

pp. 63-69

Author(s):

Anu Rajasingham ◽

Janell A. Routh ◽

Anagha Loharikar ◽

Elly Chemey ◽

Tracy Ayers ◽

...

Keyword(s):

Water Treatment ◽

Maternal Health ◽

Service Use ◽

Free Water ◽

Antenatal Clinic ◽

Maternal Health Service ◽

Middle Income ◽

Treatment Practices ◽

Hygiene Practices

Access to safe drinking water and improved hygiene are essential for preventing diarrheal diseases in low- and middle-income countries. Integrating water treatment and hygiene products into antenatal clinic care can motivate water treatment and handwashing among pregnant women. Free water hygiene kits (water storage containers, sodium hypochlorite water treatment solution, and soap) and refills of water treatment solution and soap were integrated into antenatal care and delivery services in Machinga District, Malawi, resulting in improved water treatment and hygiene practices in the home and increased maternal health service use. To determine whether water treatment and hygiene practices diffused from maternal health program participants to friends and relatives households in the same communities, we assessed the practices of 106 nonpregnant friends and relatives of these new mothers at baseline and 1-year follow-up. At follow-up, friends and relatives were more likely than at baseline to have water treatment products observable in the home (33.3% vs. 1.2%, p < 0.00001) and detectable free chlorine residual in their water, confirming water treatment (35.7% vs. 1.4%; p < 0.00001). Qualitative data from in-depth interviews also suggested that program participants helped motivate adoption of water treatment and hygiene behaviors among their friends and relatives.

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Reducing Levels of Perfectionism in Gifted and Talented Youth Through a Mindfulness Intervention

Gifted Child Quarterly ◽

10.1177/0016986220953392 ◽

2020 ◽

Vol 64 (4) ◽

pp. 319-330

Author(s):

Sophia Olton-Weber ◽

Robyn Hess ◽

Jennifer A. Ritchotte

Keyword(s):

Gifted And Talented ◽

Repeated Measures ◽

Well Being ◽

School Students ◽

Post Intervention ◽

Mindfulness Intervention ◽

Socially Prescribed Perfectionism ◽

Mindfulness Practices ◽

Gifted Youth

Gifted youth frequently experience perfectionism, which for some can affect their emotional well-being. This study evaluated the effectiveness of a 6-week mindfulness intervention for 42 middle school students who were identified as Gifted and Talented. Participants’ levels of self-oriented and socially prescribed perfectionism, as well as their use of mindfulness practices, were evaluated pre- and post- intervention, as well as at a 5-week follow-up to assess changes in perfectionism ratings and use of mindfulness. Three Bonferroni-adjusted, one-way, repeated measures analyses of variance were performed, and the results indicated a significant decrease in self-oriented perfectionism and an increase in mindfulness at both the end of the intervention and at follow-up. These findings support the use of mindfulness as an appropriate intervention to reduce self-imposed forms of perfectionism among gifted youth.

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279: Effects of tocolysis with atosiban or nifedipine on infant development: follow-up of the APOSTEL III-trial

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2018.11.300 ◽

2019 ◽

Vol 220 (1) ◽

pp. S199

Author(s):

Tijn M. van Winden ◽

Christiana A. Naaktgeboren ◽

Marijn A. Tichelaar ◽

Tobias A. Nijman ◽

Cornelieke van de Beek ◽

...

Keyword(s):

Infant Development

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Assessment of Infant Development During an 18-Month Follow-Up After Treatment of Infections in Pregnant Women with Cefuroxime Axetil

Drug Safety ◽

10.2165/00002018-200022010-00007 ◽

2000 ◽

Vol 22 (1) ◽

pp. 83-88 ◽

Cited By ~ 19

Author(s):

Wiktor Manka ◽

Rafal Solowiow ◽

Dariusz Okrzeja

Keyword(s):

Pregnant Women ◽

Infant Development ◽

Cefuroxime Axetil

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Longitudinal Data Analysis for Generalized Linear Models Under Participant-Driven Informative Follow-up: An Application in Maternal Health Epidemiology

American Journal of Epidemiology ◽

10.1093/aje/kwp353 ◽

2009 ◽

Vol 171 (2) ◽

pp. 189-197 ◽

Cited By ~ 12

Author(s):

P. Buzkova ◽

E. R. Brown ◽

G. C. John-Stewart

Keyword(s):

Data Analysis ◽

Maternal Health ◽

Longitudinal Data ◽

Generalized Linear Models ◽

Linear Models ◽

Longitudinal Data Analysis

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Neurodevelopmental Outcomes of Preterm Infants Treated with Oral Paracetamol Versus Ibuprofen for Patent Ductus Arteriosus

American Journal of Perinatology ◽

10.1055/s-0037-1601564 ◽

2017 ◽

Vol 34 (12) ◽

pp. 1185-1189 ◽

Cited By ~ 11

Author(s):

Zeynep Eras ◽

Nurdan Uras ◽

Fuat Canpolat ◽

Omer Erdeve ◽

Serife Oguz ◽

...

Keyword(s):

Patent Ductus Arteriosus ◽

Preterm Infants ◽

Infant Development ◽

Controlled Trial ◽

Ductus Arteriosus ◽

Neurodevelopmental Outcomes ◽

Significant Difference ◽

Oral Ibuprofen ◽

Patent Ductus

Objective This study aims to determine the effects of paracetamol versus ibuprofen treatment given to preterm infants for the pharmacological closure of patent ductus arteriosus (PDA) on neurodevelopmental outcomes at 18 to 24 months' corrected age. Method A follow-up study was conducted to evaluate the neurodevelopmental outcomes of preterm infants (gestational age ≤ 30 weeks) enrolled in a randomized controlled trial comparing oral paracetamol versus oral ibuprofen for the closure of PDA. The developmental assessment was done by using “Bayley Scales of Infant Development, Second Edition” at 18 to 24 months' corrected age. Results A total of 80 infants completed the trial protocol. Of the 75 infants eligible for follow-up, 61 infants (30 in the paracetamol group and 31 in the ibuprofen group) were evaluated. There was no significant difference in neurodevelopmental outcomes between the two groups. Conclusion The neurodevelopmental outcomes did not differ among the preterm infants who receive either paracetamol or ibuprofen at 18 to 24 months' corrected age.

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Use of the Ages and Stages Questionnaire and Bayley Scales of Infant Development-II in neurodevelopmental follow-up of extremely low birth weight infants

Journal of Perinatology ◽

10.1038/jp.2011.1 ◽

2011 ◽

Vol 31 (10) ◽

pp. 641-646 ◽

Cited By ~ 20

Author(s):

B J Woodward ◽

L-A Papile ◽

J R Lowe ◽

V L Laadt ◽

M L Shaffer ◽

...

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Infant Development ◽

Extremely Low Birth Weight ◽

Low Birth Weight Infants ◽

Ages And Stages Questionnaire ◽

Bayley Scales

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Mindfulness for Motor and Nonmotor Dysfunctions in Parkinson’s Disease

Parkinson s Disease ◽

10.1155/2016/7109052 ◽

2016 ◽

Vol 2016 ◽

pp. 1-13 ◽

Cited By ~ 8

Author(s):

Nadeeka N. W. Dissanayaka ◽

Farah Idu Jion ◽

Nancy A. Pachana ◽

John D. O’Sullivan ◽

Rodney Marsh ◽

...

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Rating Scale ◽

Controlled Trial ◽

Nonparametric Tests ◽

Life Questionnaire ◽

Mindfulness Intervention

Background. Motor and nonmotor symptoms negatively influence Parkinson’s disease (PD) patients’ quality of life. Mindfulness interventions have been a recent focus in PD. The present study explores effectiveness of a manualized group mindfulness intervention tailored for PD in improving both motor and neuropsychiatric deficits in PD.Methods. Fourteen PD patients completed an 8-week mindfulness intervention that included 6 sessions. The Five Facet Mindfulness Questionnaire (FFMQ), Geriatric Anxiety Inventory, Hamilton Depression Rating Scale, PD Cognitive Rating Scale, Unified PD Rating Scale, PD Quality of Life Questionnaire, and Outcome Questionnaire (OQ-45) were administered before and after the intervention. Participants also completed the FFMQ-15 at each session. Gains at postassessment and at 6-month follow-up were compared to baseline using pairedt-tests and Wilcoxon nonparametric tests.Results. A significant increase in FFMQ-Observe subscale, a reduction in anxiety, depression, and OQ-45 symptom distress, an increase in PDCRS-Subcortical scores, and an improvement in postural instability, gait, and rigidity motor symptoms were observed at postassessment. Gains for the PDCRS were sustained at follow-up.Conclusion. The mindfulness intervention tailored for PD is associated with reduced anxiety and depression and improved cognitive and motor functioning. A randomised controlled trial using a large sample of PD patients is warranted.

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The Infant Development Distress (IDD) Syndrome: A Predictor of Impaired Development?

Australian & New Zealand Journal of Psychiatry ◽

10.3109/00048677509159841 ◽

1975 ◽

Vol 9 (3) ◽

pp. 153-158 ◽

Cited By ~ 16

Author(s):

Wallace Ironside

Keyword(s):

Infant Development ◽

Predictive Power ◽

The Third ◽

Healthy Infants ◽

Developmental Disturbance

A group of eight infants with a disorder termed the IDD syndrome and another group of eight matched healthy infants taken into study at the same time have been followed-up for 6.75 years. The follow-up technique and some findings are described. Three IDD syndrome children are still severely disturbed. Three others show recovery from severe developmental disturbance. But one child who was grossly abused after being taken into the study has been well since the third follow-up. The comparison children have not experienced comparable problems. A qualified affirmative to the question of predictive power is given and discussed.

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