Differential action of spasmolytic vasodilators on platelet aggregation and endothelial cell-dependent anti-aggregation

Acta Anaesthesiologica Scandinavica ◽

10.1034/j.1399-6576.2000.440410.x ◽

2000 ◽

Vol 44 (4) ◽

pp. 417-422 ◽

Author(s):

T. Az-Ma ◽

N. Saeki ◽

O. Yuge

Keyword(s):

Endothelial Cell ◽

Platelet Aggregation ◽

Differential Action

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Continuous Infusion of Prostacyclin Normalizes Plasma Markers of Endothelial Cell Injury and Platelet Aggregation in Primary Pulmonary Hypertension

Circulation ◽

10.1161/01.cir.96.9.2782 ◽

1997 ◽

Vol 96 (9) ◽

pp. 2782-2784 ◽

Author(s):

Ronit Friedman ◽

J. Gregory Mears ◽

Robyn J. Barst

Keyword(s):

Pulmonary Hypertension ◽

Endothelial Cell ◽

Platelet Aggregation ◽

Continuous Infusion ◽

Cell Injury ◽

Primary Pulmonary Hypertension ◽

Endothelial Cell Injury ◽

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Snake venom disintegrin, saxatilin, inhibits platelet aggregation, human umbilical vein endothelial cell proliferation, and smooth muscle cell migration

Thrombosis Research ◽

10.1016/s0049-3848(01)00416-9 ◽

2002 ◽

Vol 105 (1) ◽

pp. 79-86 ◽

Author(s):

Sung-Yu Hong ◽

You-Seok Koh ◽

Kwang-Hoe Chung ◽

Doo-Sik Kim

Keyword(s):

Cell Proliferation ◽

Smooth Muscle ◽

Cell Migration ◽

Endothelial Cell ◽

Platelet Aggregation ◽

Smooth Muscle Cell ◽

Muscle Cell ◽

Umbilical Vein ◽

Endothelial Cell Proliferation ◽

Smooth Muscle Cell Migration

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Ischemia reperfusion-facilitated sinusoidal endothelial cell injury in liver transplantation and the resulting impact of extravasated platelet aggregation

European Surgery ◽

10.1007/s10353-015-0363-3 ◽

2015 ◽

Vol 48 (2) ◽

pp. 92-98 ◽

Author(s):

T. Miyashita ◽

S. Nakanuma ◽

A.K. Ahmed ◽

I. Makino ◽

H. Hayashi ◽

...

Keyword(s):

Liver Transplantation ◽

Endothelial Cell ◽

Platelet Aggregation ◽

Cell Injury ◽

Ischemia Reperfusion ◽

Sinusoidal Endothelial Cell ◽

Endothelial Cell Injury

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Krüppel-like factor 10 upregulates the expression of cyclooxygenase 1 and further modulates angiogenesis in endothelial cell and platelet aggregation in gene-deficient mice

The International Journal of Biochemistry & Cell Biology ◽

10.1016/j.biocel.2012.11.007 ◽

2013 ◽

Vol 45 (2) ◽

pp. 419-428 ◽

Author(s):

Diane H.A. Yang ◽

Ching-Fang Hsu ◽

Chun-Yu Lin ◽

Jia-Yi Guo ◽

Winston C.Y. Yu ◽

...

Keyword(s):

Endothelial Cell ◽

Platelet Aggregation ◽

Cyclooxygenase 1 ◽

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Synthesis of antiplatelet ortho-carbonyl hydroquinones with differential action on platelet aggregation stimulated by collagen or TRAP-6

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2020.112187 ◽

2020 ◽

Vol 192 ◽

pp. 112187 ◽

Author(s):

Diego Méndez ◽

Félix A. Urra ◽

Juan Pablo Millas-Vargas ◽

Marcelo Alarcón ◽

Julio Rodríguez-Lavado ◽

...

Keyword(s):

Platelet Aggregation ◽

Differential Action

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Relative effects of GAL+ and GALlow/- porcine hematopoietic cells on primate platelet aggregation and endothelial cell activation: implications for the induction of mixed hematopoietic chimerism in the pig-to-primate model

Xenotransplantation ◽

10.1111/j.1399-3089.2004.00085.x ◽

2004 ◽

Vol 11 (1) ◽

pp. 72-77 ◽

Author(s):

Christoph Knosalla ◽

Maria A. Giovino ◽

David Harper ◽

Elzbieta Kaczmarek ◽

Bernd Gollackner ◽

...

Keyword(s):

Endothelial Cell ◽

Platelet Aggregation ◽

Cell Activation ◽

Hematopoietic Cells ◽

Endothelial Cell Activation ◽

Primate Model ◽

Hematopoietic Chimerism

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Changes of spontaneous and induced platelet aggregation in the presence of a human endothelial cell monolayer

Thrombosis Research ◽

10.1016/0049-3848(89)90457-x ◽

1989 ◽

Vol 55 (1) ◽

pp. 69-77 ◽

Author(s):

I. Altorjay ◽

C.M. Kirchmaier ◽

H.K. Breddin

Keyword(s):

Endothelial Cell ◽

Platelet Aggregation ◽

Cell Monolayer ◽

Human Endothelial Cell ◽

Endothelial Cell Monolayer

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The Protein-tyrosine Phosphatase SHP-2 Binds Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1) and Forms a Distinct Signaling Complex during Platelet Aggregation

Journal of Biological Chemistry ◽

10.1074/jbc.272.11.6986 ◽

1997 ◽

Vol 272 (11) ◽

pp. 6986-6993 ◽

Author(s):

Denise E. Jackson ◽

Christopher M. Ward ◽

Ronggang Wang ◽

Peter J. Newman

Keyword(s):

Cell Adhesion ◽

Endothelial Cell ◽

Platelet Aggregation ◽

Protein Tyrosine Phosphatase ◽

Cell Adhesion Molecule ◽

Tyrosine Phosphatase ◽

Signaling Complex ◽

Platelet Endothelial Cell Adhesion ◽

Cell Adhesion Molecule 1 ◽

Endothelial Cell Adhesion

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Phospholipids released from activated platelets improve platelet aggregation and endothelial cell migration

Platelets ◽

10.1080/09537100120039389 ◽

2001 ◽

Vol 12 (3) ◽

pp. 163-170 ◽

Author(s):

Hongyan Xiao ◽

Rafat A. Siddiqui ◽

Mohammed H. Al-Hassani ◽

Daniel Sliva ◽

Richard J. Kovacs

Keyword(s):

Cell Migration ◽

Endothelial Cell ◽

Platelet Aggregation ◽

Endothelial Cell Migration ◽

Activated Platelets

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Effect of Tranylcypromine on Platelet Aggregation Induced by Thrombin, ADP, Adrenaline, Collagen and Arachidonic ACID

10.1055/s-0039-1687602 ◽

1979 ◽

Author(s):

C. Busch ◽

C. Ljungman ◽

L. Birgersson

Keyword(s):

Arachidonic Acid ◽

Endothelial Cell ◽

Platelet Aggregation ◽

Thromboxane A2 ◽

Inhibitory Effect ◽

Selective Inhibitor ◽

The Other ◽

Common Pathway ◽

Prostacyclin Synthesis ◽

Platelet Functions

The monoaminooxidase inhibitor tranylcypromine has been suggested to be a selective inhibitor of prostacyclin synthetase with no inhibitory effect on thromboxane A2 formation in platelets. The substance would then be a suitable tool for discrimination between prostacyclin synthesis and release on one hand and other possible thrombocytophobic properties of the endothelial cell particularly its surface on the other. This study, however, shows that tranylcypromine interferes with platelet aggregation induced by thrombin, ADP, adrenaline and collagen whereas that of arachidonic acid is not affected. The results indicate an inhibition at an earlier common pathway of platelet aggregation than the metabolism of arachidonic acid. It is also suggested that the search for a selective inhibitor of prostacyclin synthesis which does not interfere with platelet functions should continue.

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