The serotonin-2A receptor polymorphism and clinical symptoms in mood disorders, schizophrenia and alcohol dependence in Japan

2003 ◽  
Vol 15 (3) ◽  
pp. 129-132 ◽  
Author(s):  
Hayato Terayama ◽  
Takahiro Takimoto ◽  
Isao Fukunishi ◽  
Masahiro Itoh ◽  
Kazuhiko Iwahashi
Keyword(s):  
Alcohol Dependence ◽  
Mood Disorders ◽  
Serotonin Receptor ◽  
Clinical Symptoms ◽  
The Novel ◽  
Genetic Studies ◽  
Serotonin 2A Receptor ◽  
The Past ◽  
Polymerase Chain ◽  
Serotonin 2A

In the past, there have been many epidemiological and genetic studies of mood disorders, schizophrenia, and alcohol dependence, and in this study, the human serotonin 2A receptor (5-HTR2A) polymorphism was examined in 80 patients with mood disorders, 50 patients with schizophrenia and 41 patients with alcohol dependence. 5-HTR is related to affectivity, regulation, and pharmacologic effects of antidepressant, anti-anxiety and antipsychotic medications. The polymorphism in 5-HTR2A (102T/C, −1438 A/G) was identified by the polymerase chain reaction (PCR), followed by restriction fragment length polymorphism (RFLP). The results suggest that 5-HTR2A (102T/C, −1438G/A) polymorphism might not be associated with susceptibility to schizophrenia or mood disorders, and it might not be a risk factor contributing to alcohol dependency. We found that the 102T/C polymorphism was in linkage disequilibrium with the −1438G/A polymorphism in psychosis (mood disorder, schizophrenia, and alcohol dependence) and in health controls. Further studies are needed to determine whether or not the novel serotonin receptor (5-HTR) polymorphism reflects the pathogenesis of schizophrenia, mood disorders, and alcohol dependence.

No association between serotonin-2A receptor gene polymorphism and psychotic symptomatology of mood disorders

1999 ◽  
Vol 86 (3) ◽  
pp. 203-209 ◽  
Author(s):  
Alessandro Serretti ◽  
Roberta Lilli ◽  
Cristina Lorenzi ◽  
Enrico Smeraldi
Keyword(s):  
Gene Polymorphism ◽  
Mood Disorders ◽  
Receptor Gene ◽  
Serotonin 2A Receptor ◽  
Receptor Gene Polymorphism ◽  
Serotonin 2A

Serotonin-2A receptor polymorphism (102T/C) in mood disorders

1999 ◽  
Vol 87 (2-3) ◽  
pp. 233-237 ◽  
Author(s):  
Shih-Jen Tsai ◽  
Chen-Jee Hong ◽  
Ching-Chi Hsu ◽  
Chih-Ya Cheng ◽  
Wen-Yu Liao ◽  
...  
Keyword(s):  
Mood Disorders ◽  
Serotonin 2A Receptor ◽  
Serotonin 2A ◽  
Receptor Polymorphism

scholarly journals Association of the Serotonin 2A Receptor rs6311 Polymorphism with Diurnal Preference in Koreans

2020 ◽  
Vol 17 (11) ◽  
pp. 1137-1142
Author(s):  
Ji Won Yeom ◽  
Seunghwa Jeong ◽  
Ju Yeon Seo ◽  
Sehyun Jeon ◽  
Heon-Jeong Lee
Keyword(s):  
Healthy Subjects ◽  
Phenotypic Expression ◽  
Korean Population ◽  
Genetic Studies ◽  
Serotonin 2A Receptor ◽  
Circadian Genes ◽  
Composite Scale ◽  
Objective Evidence ◽  
Diurnal Preference ◽  
Serotonin 2A

Objective Evidence for the association between circadian rhythm delay and depression is accumulating. Genetic studies have shown that certain polymorphisms in circadian genes are potential genetic markers of diurnal preference. Along with circadian genes, there is a growing interest in other genetic effects on circadian rhythms. This study evaluated whether the <i>HTR2A</i> rs6311 (-1438C/T) polymorphism is associated with diurnal preference in a Korean population.Methods A total of 510 healthy subjects were included in this study. All subjects were genotyped for the <i>HTR2A</i> rs6311 polymorphism and they completed the Korean version of the composite scale of morningness (CSM).Results The C allele carriers (C/C+C/T) showed significantly higher CSM scores compared to C allele non-carriers (T/T) (t=2.22, p= 0.03), suggesting the existence of a morning chronotype tendency in C allele carriers. In other words, the T/T genotype may be associated with the evening chronotype.Conclusion These results suggest that the <i>HTR2A</i> rs6311 polymorphism may be associated with diurnal preference in a healthy Korean population. The absence of the C allele may be responsible for the increasing susceptibility to eveningness in the Korean population. Further studies on <i>HTR2A</i> polymorphisms that evaluate their interactions with various candidate genes and differences in phenotypic expression of polymorphisms according to ethnic groups are warranted to fully understand their association with diurnal preference.

The serotonin 2A receptor gene in alcohol dependence and tobacco smoking

2009 ◽  
Vol 101 (1-2) ◽  
pp. 128-131 ◽  
Author(s):  
Evelise Regina Polina ◽  
Verônica Contini ◽  
Mara Helena Hutz ◽  
Claiton Henrique Dotto Bau
Keyword(s):  
Alcohol Dependence ◽  
Tobacco Smoking ◽  
Receptor Gene ◽  
Serotonin 2A Receptor ◽  
Serotonin 2A

Hydraulic Laboratory at University of Liège

2018 ◽  
pp. 80-89
Author(s):  
Willi H. Hager
Keyword(s):  
Basic Research ◽  
The Novel ◽  
University Campus ◽  
Current Position ◽  
Professional Background ◽  
The Past ◽  
Comprehensive Picture

The Hydraulic Laboratory of Liège University, Belgium, is historically considered from its foundation in 1937 to the mid-1960s. The technical facilities of the various Buildings are highlighted, along with canals and instrumentation available. It is noted that in its initial era, comparatively few basic research has been conducted, mainly due to the professional background of the professors leading the establishment. This state was improved in the past 50 years, however, particularly since the Laboratory was dislocated to its current position in the novel University Campus. Biographies of the leading persons associated with the Liège Hydraulic Laboratory are also presented, so that a comprehensive picture is given of one of the currently leading hydraulic Laboratories of Europe.

The Pornographer and McGahern's Allusive Practice

2017 ◽  
Vol 47 (2) ◽  
pp. 281-297
Author(s):  
Tom Walker
Keyword(s):  
Social Practice ◽  
Literary Tradition ◽  
The Novel ◽  
Present Value ◽  
The Past

Allusions to other texts abound in John McGahern's fiction. His works repeatedly, though diffidently, refer to literary tradition. Yet the nature of such allusiveness is still unclear. This article focuses on how allusion in The Pornographer (1979) is depicted as an intellectual and social practice, embodying particular attitudes towards the function of texts and the knowledge they represent. Moreover, the critique of the practice of allusion that the novel undertakes is shown to have broader significance in terms of McGahern's whole oeuvre and its evolving attempts to salvage something of present value from the literature of the past.

A Review on Fast Dissolving Tablet

2017 ◽  
Vol 8 (03) ◽  
Author(s):  
Sagar T. Malsane ◽  
Smita S. Aher ◽  
R. B. Saudagar
Keyword(s):  
Drug Delivery ◽  
Patient Compliance ◽  
Research Area ◽  
Oral Route ◽  
Dosage Forms ◽  
The Novel ◽  
The Past ◽  
Orally Disintegrating Tablets ◽  
Novel Drug ◽  
Experience Difficulty

Oral route is presently the gold standard in the pharmaceutical industry where it is regarded as the safest, most economical and most convenient method of drug delivery resulting in highest patient compliance. Over the past three decades, orally disintegrating tablets (FDTs) have gained considerable attention due to patient compliance. Usually, elderly people experience difficulty in swallowing the conventional dosage forms like tablets, capsules, solutions and suspensions because of tremors of extremities and dysphagia. In some cases such as motion sickness, sudden episodes of allergic attack or coughing, and an unavailability of water, swallowing conventional tablets may be difficult. One such problem can be solved in the novel drug delivery system by formulating “Fast dissolving tablets” (FDTs) which disintegrates or dissolves rapidly without water within few seconds in the mouth due to the action of superdisintegrant or maximizing pore structure in the formulation. The review describes the various formulation aspects, superdisintegrants employed and technologies developed for FDTs, along with various excipients, evaluation tests, marketed formulation and drugs used in this research area.

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