Cognitive correlates of mortality: Evidence from a population-based sample of very old adults.

The cut-off for forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) defining airflow limitation for chronic obstructive pulmonary disease (COPD) is still contested. We assessed airflow limitation prevalence by the lower limit of normal (LLN) of Global Lungs Initiative (GLI) 2012 reference values and its predictive ability for all-cause mortality and hospitalisation in very old adults (aged ≥80 years) compared with the fixed cut-off.In a Belgian population-based prospective cohort of 411 very old adults, airflow limitation prevalence by the 5th percentile of GLI 2012 z-scores (GLI-LLN) and fixed cut-off (0.70) were compared with COPD reported by general practitioners (GPs). Survival and Cox regression multivariable analysis assessed the association of airflow limitation by both cut-offs with 5-year all-cause mortality and first hospitalisation at 3 years.9.2% had airflow limitation by GLI-LLN and 27% by fixed cut-off, without good agreement (kappa coefficient ≤0.40) with GP-reported COPD (9%). Only airflow limitation by GLI-LLN was independently associated with mortality (adjusted hazard ratio 2.10, 95% CI 1.30–3.38). FEV1/FVC <0.70 but ≥GLI-LLN (17.8%) had no significantly higher risk for mortality or hospitalisation.In a cohort of very old adults, airflow limitation by GLI-LLN has lower prevalence than by fixed cut-off, independently predicts all-cause mortality and does not miss individuals with significantly higher all-cause mortality and hospitalisation.

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Vitamin D Status, Muscle Strength and Physical Performance Decline in Very Old Adults: A Prospective Study

Nutrients ◽

10.3390/nu9040379 ◽

2017 ◽

Vol 9 (4) ◽

pp. 379 ◽

Cited By ~ 24

Author(s):

Antoneta Granic ◽

Tom Hill ◽

Karen Davies ◽

Carol Jagger ◽

Ashley Adamson ◽

...

Keyword(s):

Vitamin D ◽

Muscle Strength ◽

Prospective Study ◽

Physical Performance ◽

Vitamin D Status ◽

Very Old ◽

Old Adults ◽

Performance Decline ◽

A Prospective Study

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Atrial fibrillation, stroke and dementia in the very old: A population-based study

Neurobiology of Aging ◽

10.1016/j.neurobiolaging.2009.08.002 ◽

2011 ◽

Vol 32 (7) ◽

pp. 1336-1337 ◽

Cited By ~ 38

Author(s):

Alessandra Marengoni ◽

Chengxuan Qiu ◽

Bengt Winblad ◽

Laura Fratiglioni

Keyword(s):

Atrial Fibrillation ◽

Population Based ◽

Population Based Study ◽

Very Old

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Mortality is not increased with Diabetes in Hospitalised Very Old Adults: A multi-site review.

10.21203/rs.3.rs-33535/v3 ◽

2020 ◽

Author(s):

Peter Smerdely

Keyword(s):

Length Of Stay ◽

Adverse Events ◽

Negative Binomial ◽

Negative Impact ◽

Outcome Data ◽

Teaching Hospitals ◽

Very Old ◽

Old Adults ◽

Lengths Of Stay ◽

Hospital Acquired

Abstract Background: Few data exist regarding hospital outcomes in people with diabetes aged beyond 75 years. This study aimed to explore the association of diabetes with hospital outcome in the very old patient.Methods: A retrospective review was conducted of all presentations of patients aged 65 years or more admitted to three Sydney teaching hospitals over six years (2012-2018), exploring primarily the outcomes of in-hospital mortality, and secondarily the outcomes of length of stay, the development of hospital-acquired adverse events and unplanned re-admission to hospital within 28 days of discharge. Demographic and outcome data, the presence of diabetes and comorbidities were determined from ICD10 coding within the hospital's electronic medical record. Logistic and negative binomial regression models were used to assess the association of diabetes with outcome. Results: A total of 139130 separations (mean age 80 years, range 65 to 107 years; 51% female) were included, with 49% having documented comorbidities and 26.1% a diagnosis of diabetes. When compared to people without diabetes, diabetes was not associated with increased odds of mortality (OR: 0.89 SE (0.02), p<0.001). Further, because of a significant interaction with age, diabetes was associated with decreased odds of mortality beyond 80 years of age. While people with diabetes overall had longer lengths of stay (10.2 days SD (13.4) v 9.4 days SD (12.3), p<0.001), increasing age was associated with shorter lengths of stay in people aged more than 90 years. Diabetes was associated with increased odds of hospital-acquired adverse events (OR: 1.09 SE (0.02), p<0.001) and but not 28-day re-admission (OR: 0.88 SE (0.18), p=0.523).Conclusion: Diabetes has not been shown to have a negative impact on mortality or length of stay in hospitalised very old adults from data derived from hospital administrative records. This may allow a more measured application of diabetic guidelines in the very old hospitalised patient.

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