Two-Year Decline in Vision but Not Hearing Is Associated with Memory Decline in Very Old Adults in a Population-Based Sample

AbstractSex differences in late-life memory decline may be explained by sex differences in dementia risk factors. Episodic memory and dementia risk factors were assessed in young, middle-aged and older adults over 12 years in a population-based sample (N = 7485). For men in midlife and old age, physical, cognitive and social activities were associated with less memory decline, and financial hardship was associated with more. APOE e4 and vascular risk factors were associated with memory decline for women in midlife. Depression, cognitive and physical activity were associated with memory change in older women. Incident midlife hypertension (β = − 0.48, 95% CI − 0.87, − 0.09, p = 0.02) was associated with greater memory decline in women and incident late-life stroke accounted for greater memory decline in men (β = − 0.56, 95% CI − 1.12, − 0.01), p = 0.05). Women have fewer modifiable risk factors than men. Stroke and hypertension explained sex differences in memory decline for men and women respectively.

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Episodic Memory Functioning in Population-Based Samples of Very Old Adults with Alzheimer's Disease and Vascular Dementia

Dementia and Geriatric Cognitive Disorders ◽

10.1159/000106658 ◽

1997 ◽

Vol 8 (6) ◽

pp. 376-383 ◽

Cited By ~ 12

Author(s):

Linda Hassing ◽

Lars Bäckman

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Episodic Memory ◽

Vascular Dementia ◽

Population Based ◽

Very Old ◽

Old Adults ◽

Memory Functioning

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Substantial effects of apolipoprotein E ε4 on memory decline in very old age: longitudinal findings from a population-based sample

Neurobiology of Aging ◽

10.1016/j.neurobiolaging.2013.06.002 ◽

2013 ◽

Vol 34 (12) ◽

pp. 2734-2739 ◽

Cited By ~ 14

Author(s):

Marcus Praetorius ◽

Valgeir Thorvaldsson ◽

Linda B. Hassing ◽

Boo Johansson

Keyword(s):

Apolipoprotein E ◽

Old Age ◽

Population Based ◽

Memory Decline ◽

Very Old ◽

Very Old Age

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Airflow limitation by the Global Lungs Initiative equations in a cohort of very old adults

European Respiratory Journal ◽

10.1183/09031936.00217214 ◽

2015 ◽

Vol 46 (1) ◽

pp. 123-132 ◽

Cited By ~ 13

Author(s):

Eralda Turkeshi ◽

Bert Vaes ◽

Elena Andreeva ◽

Catharina Matheï ◽

Wim Adriaensen ◽

...

Keyword(s):

Cox Regression ◽

Multivariable Analysis ◽

Predictive Ability ◽

Population Based ◽

Forced Expiratory Volume ◽

Airflow Limitation ◽

Chronic Obstructive ◽

Very Old ◽

Old Adults ◽

All Cause Mortality

The cut-off for forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) defining airflow limitation for chronic obstructive pulmonary disease (COPD) is still contested. We assessed airflow limitation prevalence by the lower limit of normal (LLN) of Global Lungs Initiative (GLI) 2012 reference values and its predictive ability for all-cause mortality and hospitalisation in very old adults (aged ≥80 years) compared with the fixed cut-off.In a Belgian population-based prospective cohort of 411 very old adults, airflow limitation prevalence by the 5th percentile of GLI 2012 z-scores (GLI-LLN) and fixed cut-off (0.70) were compared with COPD reported by general practitioners (GPs). Survival and Cox regression multivariable analysis assessed the association of airflow limitation by both cut-offs with 5-year all-cause mortality and first hospitalisation at 3 years.9.2% had airflow limitation by GLI-LLN and 27% by fixed cut-off, without good agreement (kappa coefficient ≤0.40) with GP-reported COPD (9%). Only airflow limitation by GLI-LLN was independently associated with mortality (adjusted hazard ratio 2.10, 95% CI 1.30–3.38). FEV1/FVC <0.70 but ≥GLI-LLN (17.8%) had no significantly higher risk for mortality or hospitalisation.In a cohort of very old adults, airflow limitation by GLI-LLN has lower prevalence than by fixed cut-off, independently predicts all-cause mortality and does not miss individuals with significantly higher all-cause mortality and hospitalisation.

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