scholarly journals Early amygdala damage alters the way rhesus macaques process species-specific audio-visual vocalizations.

2019 ◽  
Vol 133 (1) ◽  
pp. 1-17 ◽  
Author(s):  
Christa Payne ◽  
Jocelyne Bachevalier
Keyword(s):  
Rhesus Macaques ◽  
Species Specific ◽  
The Way

scholarly journals Sound-identity processing in early areas of the auditory ventral stream in the macaque

2012 ◽  
Vol 107 (4) ◽  
pp. 1123-1141 ◽  
Author(s):  
Paweł Kuśmierek ◽  
Michael Ortiz ◽  
Josef P. Rauschecker
Keyword(s):  
Rhesus Macaques ◽  
Population Analysis ◽  
Activity Patterns ◽  
Dorsal Stream ◽  
Stimulus Onset ◽  
Ventral Stream ◽  
Underlying Mechanisms ◽  
Species Specific ◽  
Rostral Region ◽  
Identity Processing

Auditory cortical processing is thought to be accomplished along two processing streams. The existence of a posterior/dorsal stream dealing, among others, with the processing of spatial aspects of sound has been corroborated by numerous studies in several species. An anterior/ventral stream for the processing of nonspatial sound qualities, including the identification of sounds such as species-specific vocalizations, has also received much support. Originally discovered in anterolateral belt cortex, most recent work on the anterior/ventral pathway has been performed on far anterior superior temporal (ST) areas and on ventrolateral prefrontal cortex (VLPFC). Regions of the anterior/ventral stream near its origin in early auditory areas have been less explored. In the present study, we examined three early auditory regions with different anteroposterior locations (caudal, middle, and rostral) in awake rhesus macaques. We analyzed how well classification based on sound-evoked activity patterns of neuronal populations replicates the original stimulus categories. Of the three regions, the rostral region (rR), which included core area R and medial belt area RM, yielded the greatest classification success across all stimulus classes or between classes of natural sounds. Starting from ∼80 ms past stimulus onset, clustering based on the population response in rR became clearly more successful than clustering based on responses from any other region. Our study demonstrates that specialization for sound-identity processing can be found very early in the auditory ventral stream. Furthermore, the fact that this processing develops over time can shed light on underlying mechanisms. Finally, we show that population analysis is a more sensitive method for revealing functional specialization than conventional types of analysis.

scholarly journals Differential CD4+ T-Lymphocyte Apoptosis and Bystander T-Cell Activation in Rhesus Macaques and Sooty Mangabeys during Acute Simian Immunodeficiency Virus Infection

2008 ◽  
Vol 83 (2) ◽  
pp. 572-583 ◽  
Author(s):  
Mareike Meythaler ◽  
Amanda Martinot ◽  
Zichun Wang ◽  
Sarah Pryputniewicz ◽  
Melissa Kasheta ◽  
...  
Keyword(s):  
Immune Response ◽  
T Lymphocytes ◽  
T Lymphocyte ◽  
Immune Activation ◽  
Rhesus Macaques ◽  
Lymphocyte Apoptosis ◽  
Immunodeficiency Virus ◽  
Sooty Mangabeys ◽  
Siv Infection ◽  
Species Specific

ABSTRACT In contrast to pathogenic lentiviral infections, chronic simian immunodeficiency virus (SIV) infection in its natural host is characterized by a lack of increased immune activation and apoptosis. To determine whether these differences are species specific and predicted by the early host response to SIV in primary infection, we longitudinally examined T-lymphocyte apoptosis, immune activation, and the SIV-specific cellular immune response in experimentally infected rhesus macaques (RM) and sooty mangabeys (SM) with controlled or uncontrolled SIV infection. SIVsmE041, a primary SIVsm isolate, reproduced set-point viremia levels of natural SIV infection in SM but was controlled in RM, while SIVmac239 replicated to high levels in RM. Following SIV infection, increased CD8+ T-lymphocyte apoptosis, temporally coinciding with onset of SIV-specific cellular immunity, and elevated plasma Th1 cytokine and gamma interferon-induced chemokine levels were common to both SM and RM. Different from SM, SIV-infected RM showed a significantly higher frequency of peripheral blood activated CD8+ T lymphocytes despite comparable magnitude of the SIV-specific gamma interferon enzyme-linked immunospot response. Furthermore, an increase in CD4+ and CD4−CD8− T-lymphocyte apoptosis and plasma tumor necrosis factor-related apoptosis-inducing ligand were observed only in RM and occurred in both controlled SIVsmE041 and uncontrolled SIVmac239 infection. These data suggest that the “excess” activated T lymphocytes in RM soon after SIV infection are predominantly of non-virus-specific bystander origin. Thus, species-specific differences in the early innate immune response appear to be an important factor contributing to differential immune activation in natural and nonnatural hosts of SIV infection.

Models of Self-Replicators

2010 ◽  
pp. 282-314
Author(s):  
Eleonora Bilotta ◽  
Pietro Pantano
Keyword(s):  
Middle Ages ◽  
External World ◽  
Human Cognition ◽  
Natural Languages ◽  
Cognitive Representations ◽  
Christopher Alexander ◽  
On Line ◽  
Instinctive Behavior ◽  
Species Specific ◽  
The Way

Structural models and patterns are vitally important for human beings. From birth, we base our emotional and cognitive representations of the external world on species-specific signals (the human face) and exploit these signals to structure our instinctive behavior. The creation of cognitive patterns to represent the world lies at the very heart of human cognition. It is this process that underlies our efficient use of signs, our ability to communicate with natural languages and to build cognitive artifacts, the way we organize the external world, and the way we organize external events in our memories and our flow of consciousness. Patterns are sometimes called schemas, or models, and discussed in terms of a gestalt (Piaget, 1960; 1970; Koelher, 1974). In the middle ages a pattern meant “the.original.proposed.to.imitation;.the. archetype;.that.which.is.to.be.copied;.an.exemplar” (from the On Line Etymology Dictionary). Modern use dates back to the XVIII century. In 1977 Christopher Alexander introduced a new way of using the term in architecture. For Alexander, a pattern was a model used to encode and organize existing knowledge, avoiding the need to reinvent the knowledge every time it was needed. For Alexander a pattern was “a three part rule, which expresses a relation between a certain context, a problem, and a solution” (Alexander et al., 1977).

scholarly journals Myeloid cell-driven nonregenerative pulmonary scarring is conserved in multiple nonhuman primate species regardless of SARS-CoV-2 infection modality

2021 ◽  
Author(s):  
Alyssa C Fears ◽  
Brandon J Beddingfield ◽  
Nicole R Chirichella ◽  
Nadia Slisarenko ◽  
Stephanie Z Killeen ◽  
...  
Keyword(s):  
Macaca Mulatta ◽  
Rhesus Macaques ◽  
Myeloid Cell ◽  
Lung Damage ◽  
Primate Species ◽  
Clinical Onset ◽  
Chlorocebus Aethiops ◽  
Novel Coronavirus ◽  
Species Specific ◽  
Green Monkeys

The novel coronavirus SARS-CoV-2 has caused a worldwide pandemic resulting in widespread efforts in development of animal models that recapitulate human disease for evaluation of medical countermeasures, and to dissect COVID-19 immunopathogenesis. We tested whether route of experimental infection substantially changes COVID-19 disease characteristics in two species (Macaca mulatta; rhesus macaques; RM, Chlorocebus atheiops; African green monkeys; AGM) of nonhuman primates. Species-specific cohorts of RM and AGM Rhesus macaques (Macaca mulatta, RMs) and African green monkeys (Chlorocebus aethiops, AGMs) were experimentally infected with homologous SARS-CoV-2 by either direct mucosal instillation or small particle aerosol in route-discrete subcohorts. Both species demonstrated equivalent infection initially by either exposure route although the magnitude and duration of viral loading was greater in AGMs than that of the RM. Clinical onset was nearly immediate (+1dpi) in mucosally-exposed cohorts whereas aerosol-infected animals began to show signs +7dpi. Myeloid cell responses indicative of the development of pulmonary scarring and extended lack of regenerative capacity in the pulmonary compartment was a conserved pathologic response in both species by either exposure modality. This pathological commonality may be useful in future anti-fibrosis therapeutic evaluations and expands our understanding of how SARS-CoV-2 infection leads to ARDS and functional lung damage.

Neural Representation of Vocalizations in the Primate Ventrolateral Prefrontal Cortex

2005 ◽  
Vol 93 (2) ◽  
pp. 734-747 ◽  
Author(s):  
Lizabeth M. Romanski ◽  
Bruno B. Averbeck ◽  
Mark Diltz
Keyword(s):  
Prefrontal Cortex ◽  
Rhesus Macaques ◽  
Neuronal Response ◽  
Hierarchical Cluster ◽  
Neural Representation ◽  
Ventrolateral Prefrontal Cortex ◽  
Information Theoretic ◽  
Vocalization Type ◽  
Species Specific

In this study, we examined the role of the ventrolateral prefrontal cortex in encoding communication stimuli. Specifically, we recorded single-unit responses from the ventrolateral prefrontal cortext (vlPFC) in awake behaving rhesus macaques in response to species-specific vocalizations. We determined the selectivity of vlPFC cells for 10 types of rhesus vocalizations and also asked what types of vocalizations cluster together in the neuronal response. The data from the present study demonstrate that vlPFC auditory neurons respond to a variety of species-specific vocalizations from a previously characterized library. Most vlPFC neurons responded to two to five vocalizations, while a small percentage of cells responded either selectively to a particular vocalization type or nonselectively to most auditory stimuli tested. Use of information theoretic approaches to examine vocalization tuning indicates that on average, vlPFC neurons encode information about one or two vocalizations. Further analysis of the types of vocalizations that vlPFC cells typically respond to using hierarchical cluster analysis suggests that the responses of vlPFC cells to multiple vocalizations is not based strictly on the call's function or meaning but may be due to other features including acoustic morphology. These data are consistent with a role for the primate vlPFC in assessing distinctive acoustic features.

Growth models in fossil arborescent cheilostome bryozoans

Paleobiology ◽  
1981 ◽  
Vol 7 (1) ◽  
pp. 68-86 ◽  
Author(s):  
Alan H. Cheetham ◽  
Lee-Ann C. Hayek ◽  
Erik Thomsen
Keyword(s):  
Mechanical Stress ◽  
Growth Models ◽  
Growth Processes ◽  
Quantitative Reconstruction ◽  
Living Species ◽  
Species Specific ◽  
Mutually Independent ◽  
Cheilostome Bryozoans ◽  
The Way

Cheilostome bryozoans that grew as rigidly erect arborescent colonies dominate many bryozoan-rich assemblages of Tertiary age, in which they are found most commonly as small dissociated fragments. The regularity with which branching and branch thickening occur in intact colonies of living species provides a basis for quantitative reconstruction of these growth processes in fossils. We propose models to describe branch thickening, develop methods to extend both thickening and branching models to fossils, investigate the thickening and branching properties of four Paleocene and five Oligocene species and compare the properties of these fossils to those of nine living species.The properties investigated are largely mutually independent and species specific irrespective of geologic age and have similar numerical ranges among different assemblages of coeval species. Species are evenly distributed across the range of possible morphologies between observed extremes, without obvious gaps. Statistically significant trends through time are identified in gradients of branch thickening, which have implications for the resistance of colonies to mechanical stress, and in angles of bifurcation, that are important in the way growing colonies occupy space.

scholarly journals Regulatory diversity contributes to a divergent transcriptional response to dietary changes in mammals

2020 ◽  
Author(s):  
Kevin R. Costello ◽  
Heon Shin ◽  
Candi Trac ◽  
Oleg Varlamov ◽  
Dustin E. Schones
Keyword(s):  
Transcription Factors ◽  
High Fat Diet ◽  
Rhesus Macaques ◽  
Regulatory Elements ◽  
Chromatin Accessibility ◽  
High Fat ◽  
Transcriptional Responses ◽  
Regulatory Changes ◽  
Transcriptional Regulatory ◽  
Species Specific

AbstractBACKGROUNDRegulatory innovation is central to the evolution of species. Different nutritional sources are one environmental pressure that can lead to selection for novel regulatory elements. Dietary composition changes, including exposure to “western” diets with excess fat and sugar content, can lead to transcriptional regulatory changes in the liver. In order to investigate how transcriptional regulatory changes in response to a high fat diet diverge across species, we profiled chromatin accessibility, histone modifications and the transcriptome in livers of rhesus macaques and mice fed high fat and normal diets.RESULTSWhile the majority of elements exhibiting changes in chromatin accessibility in response to a high fat diet are enriched for similar transcription factors across species, the loci that change are mostly species specific. These unique responsive regulatory elements are largely derived from transposable elements and are enriched for liver-specific transcription factors, such as HNF4α. Furthermore, the majority of genes that respond to a high fat diet in rhesus macaques do not have a shared response in mice and are proximal to regulatory elements that display changes in chromatin accessibility only in rhesus macaques.CONCLUSIONSOur study demonstrates that most of the liver regulatory elements that exhibit changes in chromatin accessibility in response to a high fat diet do so in a species-specific manner. These findings illustrate how a similar environmental stimulus can drive a divergent chromatin and transcriptional responses in evolutionary distinct mammalian species.

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