Intraindividual differences in sensory channel preference.

1958 ◽  
Vol 42 (3) ◽  
pp. 166-167 ◽  
Author(s):  
Brain R. Kay
Keyword(s):  
Sensory Channel ◽  
Channel Preference

Synaesthesia

2018 ◽  
Author(s):  
Bruno and
Keyword(s):  
Experimental Results ◽  
Multisensory Perception ◽  
Related Phenomenon ◽  
Perceptual Modality ◽  
Sensory Channel ◽  
Multisensory Interactions ◽  
Crossmodal Associations ◽  
The Brain

Synaesthesia is a curious anomaly of multisensory perception. When presented with stimulation in one sensory channel, in addition to the percept usually associated with that channel (inducer) a true synaesthetic experiences a second percept in another perceptual modality (concurrent). Although synaesthesia is not pathological, true synaesthetes are relatively rare and their synaesthetic associations tend to be quite idiosyncratic. For this reason, studying synaesthesia is difficult, but exciting new experimental results are beginning to clarify what makes the brain of synaesthetes special and the mechanisms that may produce the condition. Even more importantly, the related phenomenon known as ‘natural’ crossmodal associations is instead experienced by everyone, providing another useful domain for studying multisensory interactions with important implications for understanding our preferences for products in terms of spontaneously evoked associations, as well as for choosing appropriate names, labels, and packaging in marketing applications.

scholarly journals Therapeutic inhibition of keratinocyte TRPV3 sensory channel by local anesthetic dyclonine

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Qiang Liu ◽  
Jin Wang ◽  
Xin Wei ◽  
Juan Hu ◽  
Conghui Ping ◽  
...  
Keyword(s):  
Transient Receptor Potential ◽  
Single Channel ◽  
Receptor Potential ◽  
Epidermal Keratinocytes ◽  
Transient Receptor Potential Vanilloid ◽  
Growth Disorders ◽  
Open Probability ◽  
Gain Of Function ◽  
Sensory Channel

The multimodal sensory channel transient receptor potential vanilloid-3 (TRPV3) is expressed in epidermal keratinocytes and implicated in chronic pruritus, allergy, and inflammation-related skin disorders. Gain-of-function mutations of TRPV3 cause hair growth disorders in mice and Olmsted Syndrome in human. We here report that mouse and human TRPV3 channel is targeted by the clinical medication dyclonine that exerts a potent inhibitory effect. Accordingly, dyclonine rescued cell death caused by gain-of-function TRPV3 mutations and suppressed pruritus symptoms in vivo in mouse model. At the single-channel level, dyclonine inhibited TRPV3 open probability but not the unitary conductance. By molecular simulations and mutagenesis, we further uncovered key residues in TRPV3 pore region that could toggle the inhibitory efficiency of dyclonine. The functional and mechanistic insights obtained on dyclonine-TRPV3 interaction will help to conceive updated therapeutics for skin inflammation.

scholarly journals Teaching the Duck, the Rabbit, the Eagle and the Squirrel: Teachers Talk Differentiated Instruction

2021 ◽  
Author(s):  
◽  
Michèle Orban
Keyword(s):  
Learning Styles ◽  
Differentiated Instruction ◽  
Teaching Methods ◽  
Methodological Approach ◽  
Learning Preferences ◽  
Modern World ◽  
Ability Group ◽  
Sensory Channel ◽  
Readiness To Learn ◽  
Differentiated Learning

<p>Student differences become more and more acute in today’s classrooms. Our modern world is rapidly changing and the classroom societies become more and more diverse. There is an urgent need for teachers to react to these changes and particularly the classroom diversity in order to ensure learning. This thesis examines instruction methods that create a differentiated learning environment. It built on the experiences of teaching experts in the area of differentiated instruction and sought to discover effective methods to teach in a differentiated way. The methodological approach was a multiple case study lead under a constructionist approach. Four teachers who considered themselves as experts in the area of differentiated instruction volunteered to take part. They have been observed in their work environment, and their experiences and methods have been questioned in two interviews. A vivo approach has been used to transcribe the interviews and data has been analysed through analytic induction. Teachers generally agreed on differentiated instruction being a key feature of modern teaching. They admitted that they wouldn’t want to teach in any other way. All four participants organised their instruction majorly around ability group teaching and differentiated according to the students’ readiness to learn. They sometimes differentiated through interest but only rarely considered differentiation through learning styles and learning preferences when planning their activities. Nevertheless they used many methods aiming to reach every student’s preferred sensory channel or intelligence at some point rather than differentiating through it. Overall, the researcher could observe students that seemed to be at ease and to be working according to their needs. The findings from the research identified that differentiated instruction is not a myth which only exists in literature, but that it actually can be put into practice. Various teaching methods were considered and the difficulties they implicate were being discussed. Readers can learn from the participants’ teaching methods and reuse them in teaching situations. In observed classroom situations, their methods proved to be valuable and of considerable use. They can offer the readers an exciting approach to teaching and give teachers new ideas to vary their instruction. Nevertheless they cannot be generalized. There are many successful ways of teaching, in order to get to know more, further research would need to occur.</p>

TRPP2 and TRPV4 form a polymodal sensory channel complex

2008 ◽  
Vol 132 (3) ◽  
pp. i2-i2 ◽  
Author(s):  
Michael Köttgen ◽  
Björn Buchholz ◽  
Miguel A. Garcia-Gonzalez ◽  
Fruzsina Kotsis ◽  
Xiao Fu ◽  
...  
Keyword(s):  
Sensory Channel

Channel structure and differential pricing strategies in dual-channel e-retail considering e-platform business models

2020 ◽  
Vol 32 (1) ◽  
pp. 91-114
Author(s):  
Yufang Fu ◽  
Bojun Gu ◽  
Yuying Xie ◽  
Jun Ye ◽  
Bin Cao
Keyword(s):  
Service Quality ◽  
Business Models ◽  
Dynamic Game ◽  
The Self ◽  
Channel Structure ◽  
Third Party ◽  
Pricing Strategies ◽  
Dual Channel ◽  
Channel Preference ◽  
Retail Prices

Abstract Although online business has been growing for some time, third-party e-platforms and their impact on e-channels are an under-explored area in the literature on dual-channel supply chains. Considering different combinations of open and self-support e-platform, this paper develops dynamic game models in four dual-channel e-retail structures to study pricing strategies and channel preference for manufacturers. The results provide interesting insights. First, a manufacturer’s optimal prices vary in different e-channels. Second, e-retail prices on the self-support e-platform and open e-platform are both affected by the e-platform’s service quality and commission fee. Regardless of the channel structure, a better service quality by one e-platform leads to an increase in its own e-retail prices and forces the competing e-platform to either improve its service quality or take a lower price. Lastly and more importantly, we compare the manufacturer’s pricing strategies and performances in different dual-channel e-retail structures and identify its preferences. Specifically, if the commission fee is dynamic, we find that the manufacturer always prefers to use two e-channels provided by different e-platforms, and at least one of the e-channels is the self-support model, although it is a sub-optimal strategy.

Cutaneous Sensitivity Communications

1966 ◽  
Vol 8 (5) ◽  
pp. 463-469 ◽  
Author(s):  
John R. Hennessy
Keyword(s):  
Nerve Impulse ◽  
Electrical Energy ◽  
Living Systems ◽  
Communications Systems ◽  
Sensory Channel ◽  
User Acceptability

The general and specific problems facing emergence of cutaneous sensitivity devices into a useful sub-system of communications systems are discussed. The cutaneous sensory channel is emerging as a contender for application in communications systems in pace with the solution of corollary problems of psychology, neurology and bio-electronics. Transduction of electrical energy into living systems is only beginning to be understood. When suitable hardware is designed to match the nerve impulse and neuronal channels, the safety and user acceptability of cutaneous sub-systems will enhance the reliability of modern communications under extremes of environment, as well as provide an independent channel for the sensorially deprived.

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