scholarly journals Body fat distribution and noncommunicable diseases in populations: overview of the 2008 WHO Expert Consultation on Waist Circumference and Waist–Hip Ratio

2009 ◽  
Vol 64 (1) ◽  
pp. 2-5 ◽  
Author(s):  
C Nishida ◽  
G T Ko ◽  
S Kumanyika
2011 ◽  
Vol 165 (2) ◽  
pp. 243-248 ◽  
Author(s):  
Henna Cederberg ◽  
Ulla Rajala ◽  
Vesa-Matti Koivisto ◽  
Jari Jokelainen ◽  
Heljä-Marja Surcel ◽  
...  

ObjectiveGhrelin, a gut–brain peptide involved in energy homeostasis, circulates predominantly (>90%) in unacylated form. Previous studies, however, have focused on total and acylated ghrelin, and the role of unacylated ghrelin (UAG) is not well understood. Particularly, the association of UAG with weight loss and changes in body composition in adults remains unclear. We hypothesized that exercise-associated increase in UAG level is associated with weight loss, favorable changes in body composition, and body fat distribution.Design and methodsA prospective study of 552 young men (mean age 19.3 and range 19–28 years) undergoing military service with structured 6-month exercise training program. Exercise performance, body composition, and biochemical measurements were obtained at baseline and follow-up. Association between changes in UAG levels and body composition and body fat distribution were evaluated.ResultsAn increase in UAG level during the exercise intervention was associated with reduced weight, fat mass (FM), fat percentage (fat %), and waist circumference, but not with fat-free mass. Inverse associations of changes in UAG level with changes in waist circumference and fat % were independent of weight at baseline, and changes in weight and exercise performance. Associations of changes in UAG level with waist circumference were significantly stronger than with fat % after the adjustment for confounding variables.ConclusionUAG is associated with changes in body weight and body composition during an intensive long-term exercise intervention in young men. The association of UAG levels with changes in central obesity was stronger than with total FM.


2018 ◽  
Vol 108 (5) ◽  
pp. 913-921
Author(s):  
Mathilde Svendstrup ◽  
Kristine Højgaard Allin ◽  
Lars Ängquist ◽  
Peter Schnohr ◽  
Gorm Boje Jensen ◽  
...  

ABSTRACT Background Body fat distribution is a marker of metabolic health independent of body size. Visceral fat accumulation has been suggested to result from a decreased expandability of the subcutaneous fat depots. Furthermore, the visceral fat may be easier to mobilize than the peripheral fat. We examined whether differences in abdominal obesity at baseline influenced prospective body-weight changes. Objective In this study we examined whether body-fat distribution at baseline was associated with long-term and short-term weight changes. Design We included 3 observational studies (ntotal = 7271) with mean follow-up times of 5–9 y and two 8–10-wk weight loss intervention studies (ntotal = 1091). We examined the association between baseline waist circumference and weight changes in a substitution regression model, where body weight, height, and fat-free mass were fixed so that a difference in waist circumference would reflect a difference in body fat distribution alone. The results were summarized in meta-analyses. Results In the observational studies, we found no associations between baseline waist circumference and subsequent weight change in men (β: 0.03 kg; 95% CI: −0.01, 0.08 kg; P = 0.19), but a negligible inverse association in women (β: −0.05 kg; 95% CI: −0.08, −0.01 kg; P = 0.01). There was no association between baseline waist circumference and weight loss in the intervention studies (men: β: −0.05 kg; 95% CI: −0.13, 0.03 kg; P = 0.25; women: β: −0.00 kg; 95% CI: −0.03, 0.03 kg; P = 0.84). However, in all studies, the SDs of the weight change residuals were greater, the greater the waist circumference at baseline. This trend was statistically significant in women in most studies as well as in men in 1 of the studies. Conclusions With narrow CIs in 3 observational studies and 2 weight loss interventions, we did not find any clinically or epidemiologically relevant association between baseline abdominal obesity and weight change. However, the present study suggests that a greater baseline abdominal obesity is a marker for greater weight fluctuations. The CCHS trial was registered at www.clinicaltrials.gov as NCT02993172. The Health2006 trial was registered at www.clinicaltrials.gov as NCT00316667. The ORG study was conducted before trial registration was required. The NUGENOB trial was registered at www.isrctn.com as ISRCTN25867281. The DiOGenes trial was registered atwww.clinicaltrials.gov as NCT00390637.


2001 ◽  
Vol 97 (3) ◽  
pp. 338-342 ◽  
Author(s):  
HIDEKI YAMASAKI ◽  
TSUTOMU DOUCHI ◽  
SHINAKO YAMAMOTO ◽  
TOSHIMICHI OKI ◽  
RIKI KUWAHATA ◽  
...  

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