scholarly journals Stem Cells in Tissue Repair and Regeneration

2012 ◽  
Vol 132 (6) ◽  
pp. 1538-1541 ◽  
Author(s):  
Vincent Falanga
Keyword(s):  
Stem Cells ◽  
Tissue Repair ◽  
Tissue Repair And Regeneration

scholarly journals The Cross-Talk between Mesenchymal Stem Cells and Immune Cells in Tissue Repair and Regeneration

2021 ◽  
Vol 22 (5) ◽  
pp. 2472
Author(s):  
Carl Randall Harrell ◽  
Valentin Djonov ◽  
Vladislav Volarevic
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Immune Cells ◽  
Tissue Repair ◽  
Molecular Mechanisms ◽  
Current Knowledge ◽  
Multipotent Stem Cells ◽  
Tissue Repair And Regeneration ◽  
Almost All ◽  
And Function

Mesenchymal stem cells (MSCs) are self-renewable, rapidly proliferating, multipotent stem cells which reside in almost all post-natal tissues. MSCs possess potent immunoregulatory properties and, in juxtacrine and paracrine manner, modulate phenotype and function of all immune cells that participate in tissue repair and regeneration. Additionally, MSCs produce various pro-angiogenic factors and promote neo-vascularization in healing tissues, contributing to their enhanced repair and regeneration. In this review article, we summarized current knowledge about molecular mechanisms that regulate the crosstalk between MSCs and immune cells in tissue repair and regeneration.

scholarly journals Glutathione–Allylsulfur Conjugates as Mesenchymal Stem Cells Stimulating Agents for Potential Applications in Tissue Repair

2020 ◽  
Vol 21 (5) ◽  
pp. 1638 ◽  
Author(s):  
Emilia Di Giovanni ◽  
Silvia Buonvino ◽  
Ivano Amelio ◽  
Sonia Melino
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Tissue Repair ◽  
Dermal Fibroblasts ◽  
Water Soluble ◽  
Dependent Manner ◽  
Tissue Repair And Regeneration ◽  
Stem Cell Delivery ◽  
Cell Based Therapy

The endogenous gasotransmitter H2S plays an important role in the central nervous, respiratory and cardiovascular systems. Accordingly, slow-releasing H2S donors are powerful tools for basic studies and innovative pharmaco-therapeutic agents for cardiovascular and neurodegenerative diseases. Nonetheless, the effects of H2S-releasing agents on the growth of stem cells have not been fully investigated. H2S preconditioning can enhance mesenchymal stem cell survival after post-ischaemic myocardial implantation; therefore, stem cell therapy combined with H2S may be relevant in cell-based therapy for regenerative medicine. Here, we studied the effects of slow-releasing H2S agents on the cell growth and differentiation of cardiac Lin− Sca1+ human mesenchymal stem cells (cMSC) and on normal human dermal fibroblasts (NHDF). In particular, we investigated the effects of water-soluble GSH–garlic conjugates (GSGa) on cMSC compared to other H2S-releasing agents, such as Na2S and GYY4137. GSGa treatment of cMSC and NHDF increased their cell proliferation and migration in a concentration dependent manner with respect to the control. GSGa treatment promoted an upregulation of the expression of proteins involved in oxidative stress protection, cell–cell adhesion and commitment to differentiation. These results highlight the effects of H2S-natural donors as biochemical factors that promote MSC homing, increasing their safety profile and efficacy after transplantation, and the value of these donors in developing functional 3D-stem cell delivery systems for cardiac muscle tissue repair and regeneration.

scholarly journals A nanopillar array on black titanium prepared by reactive ion etching augments cardiomyogenic commitment of stem cells

Nanoscale ◽  
2019 ◽  
Vol 11 (43) ◽  
pp. 20766-20776 ◽  
Author(s):  
Lopamudra Das Ghosh ◽  
Jafar Hasan ◽  
Aditi Jain ◽  
Nagalingam R. Sundaresan ◽  
Kaushik Chatterjee
Keyword(s):  
Stem Cells ◽  
Cell Therapy ◽  
Tissue Repair ◽  
Smooth Surface ◽  
Cardiac Tissue ◽  
Ex Vivo ◽  
Reactive Ion Etching ◽  
Ion Etching ◽  
Tissue Repair And Regeneration

The array highly efficiently promotes cardiomyogenic commitment of stem cells via integrin-mediated signalling compared to the smooth surface and is a potential platform for ex vivo differentiation of stem cells for cell therapy in cardiac tissue repair and regeneration.

scholarly journals Mechanisms of Action of Human Mesenchymal Stem Cells in Tissue Repair Regeneration and their Implications

2017 ◽  
Vol 53 (02) ◽  
pp. 104-120 ◽  
Author(s):  
Manisha Singh ◽  
Suchi Gupta ◽  
Sonali Rawat ◽  
Swati Midha ◽  
Krishan Gopal Jain ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Umbilical Cord ◽  
Tissue Repair ◽  
Molecular Mechanisms ◽  
Human Mesenchymal Stem Cells ◽  
Mechanisms Of Action ◽  
Maximum Output ◽  
Cell Replacement Therapy ◽  
Tissue Repair And Regeneration

ABSTRACTCell replacement therapy holds a promising future in the treatment of degenerative diseases related to neuronal, cardiac and bone tissues. In such kind of diseases, there is a progressive loss of specific types of cells. Currently the most upcoming and trusted cell candidate is Mesenchymal Stem Cells (MSCs) as these cells are easy to isolate from the tissue, easy to maintain and expand and no ethical concerns are linked. MSCs can be obtained from a number of sources like bone marrow, umbilical cord blood, umbilical cord, dental pulp, adipose tissues, etc. MSCs help in tissue repair and regeneration by various mechanisms of action like cell differentiation, immunomodulation, paracrine effect, etc. The future of regenerative medicine lies in tissue engineering and exploiting various properties to yield maximum output. In the current review article, we have targeted the repair and regeneration mechanisms of MSCs in neurodegenerative diseases, cardiac diseases and those related to bones. Yet there is a lot to understand, discover and then understand again about the molecular mechanisms of MSCs and then applying this knowledge in developing the therapy to get maximum repair and regeneration of concerned tissue and in turn the recovery of the patient.

scholarly journals Composite Tissue Allotransplantation and Dysregulation in Tissue Repair and Regeneration: A Role for Mesenchymal Stem Cells

2013 ◽  
Vol 4 ◽  
Author(s):  
Anuja K. Antony ◽  
Katherine Rodby ◽  
Matthew K. Tobin ◽  
Megan I. O’Connor ◽  
Russell K. Pearl ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Tissue Repair ◽  
Composite Tissue Allotransplantation ◽  
Composite Tissue ◽  
Tissue Repair And Regeneration

scholarly journals Advances in mesenchymal stem cell exosomes: a review

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yaya Tang ◽  
Yan Zhou ◽  
Hong-Jun Li
Keyword(s):  
Stem Cells ◽  
Regenerative Medicine ◽  
Targeted Delivery ◽  
Tissue Repair ◽  
Medical Problems ◽  
Medicine Research ◽  
Paracrine Signalling ◽  
Tissue Repair And Regeneration ◽  
In Vitro Expansion

AbstractStem cells can be used for regenerative medicine and as treatments for disease. The application of tissue engineering-related transplantation, stem cells, and local changes in the microenvironment is expected to solve major medical problems. Currently, most studies focus on tissue repair and regeneration, and mesenchymal stem cells (MSCs) are among the most common research topics. MSCs are applicable as seed cells, and they represent one of the current hot topics in regenerative medicine research. However, due to storage limitations and because cell senescence occurs during in vitro expansion, their clinical application is challenging. Exosomes, which are secreted by MSCs through paracrine signalling, not only have the same effects as MSCs, but they also have the advantages of targeted delivery, low immunogenicity, and high repairability. This article reviews the acquisition methods, characteristics, biological functions, and clinical applications of exosomes.

scholarly journals High-Efficient Production of Adipose-Derived Stem Cell (ADSC) Secretome Through Maturation Process and Its Non-scarring Wound Healing Applications

2021 ◽  
Vol 9 ◽  
Author(s):  
Young-Hyeon An ◽  
Dae Hyun Kim ◽  
Eun Jung Lee ◽  
Dabin Lee ◽  
Mihn Jeong Park ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Tissue Repair ◽  
High Dose ◽  
Efficient Production ◽  
Skin Defect ◽  
High Concentration ◽  
Tissue Repair And Regeneration ◽  
High Efficient ◽  
Related Proteins

Recently, the stem cell-derived secretome, which is the set of proteins expressed by stem cells and secreted into the extracellular space, has been demonstrated as a critical contributor for tissue repair. In this study, we have produced two sets of high concentration secretomes from adipose-derived mesenchymal stem cells (ADSCs) that contain bovine serum or free of exogenous molecules. Through proteomic analysis, we elucidated that proteins related to extracellular matrix organization and growth factor-related proteins are highly secreted by ADSCs. Additionally, the application of ADSC secretome to full skin defect showed accelerated wound closure, enhanced angiogenic response, and complete regeneration of epithelial gaps. Furthermore, the ADSC secretome was capable of reducing scar formation. Finally, we show high-dose injection of ADSC secretome via intraperitoneal or transdermal delivery demonstrated no detectable pathological conditions in various tissues/organs, which supports the notion that ADSC secretome can be safely utilized for tissue repair and regeneration.

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