scholarly journals Synthetic hydrogels for human intestinal organoid generation and colonic wound repair

2017 ◽  
Vol 19 (11) ◽  
pp. 1326-1335 ◽  
Author(s):  
Ricardo Cruz-Acuña ◽  
Miguel Quirós ◽  
Attila E. Farkas ◽  
Priya H. Dedhia ◽  
Sha Huang ◽  
...  
Keyword(s):  
Wound Repair ◽  
Colonic Wound ◽  
Synthetic Hydrogels

Butyrate and caproate enhance colonic wound repair and modulate the expression of PCNA and cyclin D in colonic mucosa of rats with TNBS colitis

1998 ◽  
Vol 114 ◽  
pp. A1117
Author(s):  
JH Xing ◽  
HM Blottière ◽  
A. Jarry ◽  
JP Segain ◽  
C. Cherbut ◽  
...  
Keyword(s):  
Wound Repair ◽  
Colonic Mucosa ◽  
Cyclin D ◽  
Colonic Wound ◽  
Tnbs Colitis

The novel histamine H2 receptor antagonist FRG-8813 prevents delay of wound repair induced by hydrogen peroxide in a rabbit gastric epithelial cell system

1998 ◽  
Vol 13 (11-s4) ◽  
pp. S209-S213
Author(s):  
NOBUHIRO SATO ◽  
SUMIO WATANABE ◽  
XIAN-EN WANG ◽  
TARO OSADA ◽  
HIROSHI TANAKA ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Epithelial Cell ◽  
Receptor Antagonist ◽  
Wound Repair ◽  
Cell System ◽  
The Novel ◽  
H2 Receptor Antagonist ◽  
Histamine H2 Receptor ◽  
H2 Receptor ◽  
Histamine H2 Receptor Antagonist

Implications of Fibroblast Growth Factors (FGFs) in Cancer: From Prognostic to Therapeutic Applications

2019 ◽  
Vol 20 (8) ◽  
pp. 852-870
Author(s):  
Hassan Dianat-Moghadam ◽  
Ladan Teimoori-Toolabi
Keyword(s):  
Growth Factors ◽  
Wound Repair ◽  
Fibroblast Growth Factors ◽  
Predictive Biomarkers ◽  
Fibroblast Growth ◽  
Loss Of Function ◽  
Cellular Processes ◽  
Fgfr Signaling ◽  
Proliferation And Metastasis ◽  
Immense Potential

Fibroblast growth factors (FGFs) are pleiotropic molecules exerting autocrine, intracrine and paracrine functions via activating four tyrosine kinase FGF receptors (FGFR), which further trigger a variety of cellular processes including angiogenesis, evasion from apoptosis, bone formation, embryogenesis, wound repair and homeostasis. Four major mechanisms including angiogenesis, inflammation, cell proliferation, and metastasis are active in FGF/FGFR-driven tumors. Furthermore, gain-of-function or loss-of-function in FGFRs1-4 which is due to amplification, fusions, mutations, and changes in tumor–stromal cells interactions, is associated with the development and progression of cancer. Although, the developed small molecule or antibodies targeting FGFR signaling offer immense potential for cancer therapy, emergence of drug resistance, activation of compensatory pathways and systemic toxicity of modulators are bottlenecks in clinical application of anti-FGFRs. In this review, we present FGF/FGFR structure and the mechanisms of its function, as well as cross-talks with other nodes and/or signaling pathways. We describe deregulation of FGF/FGFR-related mechanisms in human disease and tumor progression leading to the presentation of emerging therapeutic approaches, resistance to FGFR targeting, and clinical potentials of individual FGF family in several human cancers. Additionally, the underlying biological mechanisms of FGF/FGFR signaling, besides several attempts to develop predictive biomarkers and combination therapies for different cancers have been explored.

Wound Repair - Updates in Dressing Patents and Regeneration Biomarkers

2015 ◽  
Vol 4 (3) ◽  
pp. 133-149 ◽  
Author(s):  
Carolina Constantin ◽  
Georgeta Paunica-Panea ◽  
Vlad D. Constantin ◽  
Monica Neagu
Keyword(s):  
Wound Repair

scholarly journals Serum and synovial fluid lipidomic profiles predict obesity-associated osteoarthritis, synovitis, and wound repair

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Chia-Lung Wu ◽  
Kelly A. Kimmerling ◽  
Dianne Little ◽  
Farshid Guilak
Keyword(s):  
Synovial Fluid ◽  
Wound Repair

scholarly journals Glandular Stem Cells in the Skin during Development, Homeostasis, Wound Repair and Regeneration

2021 ◽  
Author(s):  
Meng‐Ju Lin ◽  
Pei‐ju Catherine Lu
Keyword(s):  
Stem Cells ◽  
Wound Repair
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