Is CoQ a membrane stabilizer?

2014 ◽  
Vol 10 (4) ◽  
pp. 242-243 ◽  
Author(s):  
Catherine F Clarke ◽  
Amy C Rowat ◽  
James W Gober
Keyword(s):  
Membrane Stabilizer

scholarly journals Silybum marianum: Beyond Hepatoprotection

2015 ◽  
Vol 20 (4) ◽  
pp. 292-301 ◽  
Author(s):  
Mahmood Bahmani ◽  
Hedayatollah Shirzad ◽  
Samira Rafieian ◽  
Mahmoud Rafieian-Kopaei
Keyword(s):  
Insulin Resistance ◽  
Hepatoprotective Activity ◽  
Review Article ◽  
Cell Permeability ◽  
Silybum Marianum ◽  
Renal Protection ◽  
Liver Disorders ◽  
Membrane Stabilizer ◽  
Cirrhotic Patients ◽  
Stimulation Of

Silybum marianum is a medicinal plant that has long been used as hepatoprotective remedy. It has been used for the treatment of numerous liver disorders characterized by functional impairment or degenerative necrosis. Its hepatoprotective activity is unique and acts in different ways, including antioxidant and anti-inflammatory activities, cell permeability regulator and membrane stabilizer, stimulation of liver regeneration and inhibition of deposition in collagen fibers, which may lead to cirrhosis. Most of documented data with Silybum marianum are about liver disorders; however, recently several beneficial properties on a wide variety of other disorders such as renal protection, hypolipidemic and anti-atherosclerosis activities, cardiovascular protection, prevention of insulin resistance, especially in cirrhotic patients, cancer, and Alzheimer prevention. It is also used as a food remedy. This review article aims to present different aspects of Silybum marianum, especially the data in recently published articles about its effects on different diseases, apart from presenting the aspects of its hepatoprotection.

scholarly journals Clinical Evidence for Q10 Coenzyme Supplementation in Heart Failure: From Energetics to Functional Improvement

2020 ◽  
Vol 9 (5) ◽  
pp. 1266 ◽  
Author(s):  
Anna Di Lorenzo ◽  
Gabriella Iannuzzo ◽  
Alessandro Parlato ◽  
Gianluigi Cuomo ◽  
Crescenzo Testa ◽  
...  
Keyword(s):  
Heart Failure ◽  
Oxidative Phosphorylation ◽  
Functional Improvement ◽  
Reduced Form ◽  
Clinical Effects ◽  
Safety Issues ◽  
Coq10 Deficiency ◽  
Hemodynamic Profile ◽  
Membrane Stabilizer ◽  
Coq10 Supplementation

Oxidative stress and mitochondrial dysfunction are hallmarks of heart failure (HF). Coenzyme Q10 (CoQ10) is a vitamin-like organic compound widely expressed in humans as ubiquinol (reduced form) and ubiquinone (oxidized form). CoQ10 plays a key role in electron transport in oxidative phosphorylation of mitochondria. CoQ10 acts as a potent antioxidant, membrane stabilizer and cofactor in the production of adenosine triphosphate by oxidative phosphorylation, inhibiting the oxidation of proteins and DNA. Patients with HF showed CoQ10 deficiency; therefore, a number of clinical trials investigating the effects of CoQ10 supplementation in HF have been conducted. CoQ10 supplementation may confer potential prognostic advantages in HF patients with no adverse hemodynamic profile or safety issues. The latest evidence on the clinical effects of CoQ10 supplementation in HF was reviewed.

scholarly journals VBP15, a novel anti‐inflammatory and membrane‐stabilizer, improves muscular dystrophy without side effects

2013 ◽  
Vol 5 (10) ◽  
pp. 1569-1585 ◽  
Author(s):  
Christopher R. Heier ◽  
Jesse M. Damsker ◽  
Qing Yu ◽  
Blythe C. Dillingham ◽  
Tony Huynh ◽  
...  
Keyword(s):  
Side Effects ◽  
Muscular Dystrophy ◽  
Membrane Stabilizer ◽  
Anti Inflammatory

Effect of addition of trehalose on the liquid storage (5°C) of mithun (Bos frontalis) semen

2015 ◽  
Vol 49 (6) ◽  
Author(s):  
P. Perumal ◽  
Kezhavituo Vupru ◽  
C. Rajkhowa
Keyword(s):  
Lipid Peroxide ◽  
Sperm Parameters ◽  
Control Group ◽  
Protective Effects ◽  
Membrane Stabilizer ◽  
Sperm Membrane ◽  
Biochemical Profiles ◽  
Group 2

The present study was undertaken to assess the effect of trehalose on sperm parameters, enzymatic profiles and biochemical profiles of seminal plasma of mithun. The semen ejaculates were collected from mithun and was split into four groups as group 1: semen without additives (control), group 2 to 4: semen with 50 mM, 75 mM and 100 mM of trehalose, respectively in EYTC extender. These parameters were assessed at 5°C for 0, 6, 12, 24 and 30 h of incubation. Inclusion of trehalose resulted in significant (p < 0.05) decrease in percentages of dead spermatozoa, abnormal spermatozoa and acrosomal abnormalities as compared with control group. Additionally, trehalose at 50 mM has significant improvement in quality of mithun semen in <italic>in- vitro</italic> storage. It was due to the protective effects of trehalose on sperm parameters as sperm membrane stabilizer and prevents efflux of cholesterol, lipid peroxide formation and biochemical enzymes from sperm cell during preservation.

Calcium Signaling in Neuronal Cells Exposed to the Munitions Compound Cyclotrimethylenetrinitramine (RDX)

2009 ◽  
Vol 28 (5) ◽  
pp. 425-435 ◽  
Author(s):  
Marion Ehrich ◽  
Xiaohua Wu ◽  
Stephen R. Werre ◽  
Michael A. Major ◽  
Wilfred C. McCain ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Ethylene Glycol ◽  
Calcium Channel ◽  
Calcium Signaling ◽  
Intracellular Calcium ◽  
Animal Studies ◽  
Channel Blocker ◽  
Neuroblastoma Cells ◽  
Atpase Inhibitor ◽  
Membrane Stabilizer

Cyclotrimethylenetrinitramine (RDX) has been used extensively as an explosive in military munitions. Mechanisms for seizure production, seen in past animal studies, have not been described. Increased calcium levels contribute to excitotoxicity, so in this study neuroblastoma cells are loaded with calcium-indicating dye before application of 1.5 µM to 7.5 mM RDX, with fluorescence recorded for 30 cycles of 11 seconds each. The lowest concentration of RDX increases calcium fluorescence significantly above baseline for cycles 2 to 8; millimolar concentrations increase calcium fluorescence significantly above baseline for cycles 2 to 30. Increases in calcium, like those of 200 nM carbachol, are prevented with 10 mM of calcium chelator ethylene glycol-bis(β-aminoethyl ether)-N,N,N,N tetra-acetic acid (EGTA, tetrasodium salt). Calcium channel blocker verapamil (20 μM), Ca2+-ATPase inhibitor thapsigargin (5 μM), and general membrane stabilizer lidocaine (10 mM) partially attenuate carbachol- and RDX-induced increases in calcium, suggesting that RDX transiently increases intracellular calcium by multiple mechanisms.

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