scholarly journals Rectified directional sensing in long-range cell migration

2014 ◽  
Vol 5 (1) ◽  
Author(s):  
Akihiko Nakajima ◽  
Shuji Ishihara ◽  
Daisuke Imoto ◽  
Satoshi Sawai
Development ◽  
2020 ◽  
Vol 147 (14) ◽  
pp. dev184234 ◽  
Author(s):  
Amanda Haage ◽  
Kelsey Wagner ◽  
Wenjun Deng ◽  
Bhavya Venkatesh ◽  
Caitlin Mitchell ◽  
...  

ABSTRACTMelanoblasts disperse throughout the skin and populate hair follicles through long-range cell migration. During migration, cells undergo cycles of coordinated attachment and detachment from the extracellular matrix (ECM). Embryonic migration processes that require cell-ECM attachment are dependent on the integrin family of adhesion receptors. Precise regulation of integrin-mediated adhesion is important for many developmental migration events. However, the mechanisms that regulate integrin-mediated adhesion in vivo in melanoblasts are not well understood. Here, we show that autoinhibitory regulation of the integrin-associated adapter protein talin coordinates cell-ECM adhesion during melanoblast migration in vivo. Specifically, an autoinhibition-defective talin mutant strengthens and stabilizes integrin-based adhesions in melanocytes, which impinges on their ability to migrate. Mice with defective talin autoinhibition exhibit delays in melanoblast migration and pigmentation defects. Our results show that coordinated integrin-mediated cell-ECM attachment is essential for melanoblast migration and that talin autoinhibition is an important mechanism for fine-tuning cell-ECM adhesion during cell migration in development.


Frequenz ◽  
2018 ◽  
Vol 72 (7-8) ◽  
pp. 391-399 ◽  
Author(s):  
Hamid Dehghani ◽  
Navid Daryasafar

Abstract Using Probability Hypothesis Density (PHD) filtering, a novel approach is proposed in this paper for simultaneous tracking of multiple moving targets in received data by Inverse Synthetic Aperture Radar (ISAR) system. Since PHD filtering approach is implemented successively in prediction and update steps, its performance quality will obviously be higher in “Spotlight” imaging mode than in “Stripmap”. Thus, its application to Spotlight mode is generally more logical. The idea to integrate tracking capability into ISAR system processor is to sort radar received data to correct Range Cell Migration (RCM) prior to tracking operations. Clearly, Range Cell Migration Compensation (RCMC) approach is different from this approach in image formation process, in terms of their implementation phase. However, they are implemented in a similar way. As simulation results reveal, applying Range Cell Migration Compensation to the raw data received by ISAR before tracking operation, results in high quality tracking of moving targets.


2016 ◽  
Vol 2016 ◽  
pp. 1-15
Author(s):  
Shichao Chen ◽  
Ming Liu ◽  
Jun Wang ◽  
Fugang Lu ◽  
Mengdao Xing

A frequency scaling (FS) imaging algorithm is proposed for spotlight bistatic SAR data processing. Range cell migration correction (RCMC) is realized through phase multiplication. The proposed algorithm is insensitive to the length of the baseline due to the high precision of the point target (PT) spectrum that we are based on. It is capable of handling bistatic SAR data with a large baseline to range ratio. The algorithms suitable for small and high squint angles are both discussed according to whether the range dependence of the second range compression (SRC) can be neglected or not. Simulated experiments validate the effectiveness of the proposed algorithm.


2020 ◽  
Vol 59 (9) ◽  
pp. 2874
Author(s):  
Guangzuo Li ◽  
Zenghui Zhang ◽  
Yifei Zhang ◽  
Sujuan Fang ◽  
Wen Hong ◽  
...  

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