Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate

1997 ◽  
Vol 3 (8) ◽  
pp. 866-871 ◽  
Author(s):  
Yaping Chen ◽  
Terry Maguire ◽  
Ronald E. Hileman ◽  
Jonathan R. Fromm ◽  
Jeffrey D. Esko ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Protein Binding ◽  
Heparan Sulfate ◽  
Target Cell ◽  
Envelope Protein ◽  
Virus Infectivity

scholarly journals HEPARAN SULFATE: LANDING SITE FOR THE DENGUE VIRAL STRAINS TO GAIN ENTRY TO THE HOST CELLS

2021 ◽  
pp. 15-20
Author(s):  
ABDUL GHAYUM PAPULZAI ◽  
NIKHIYA MANUEL JOHN ◽  
SUDHAKAR MALLA
Keyword(s):  
Cell Culture ◽  
Dengue Virus ◽  
Heparan Sulfate ◽  
Envelope Protein ◽  
Landing Site ◽  
Host Cells ◽  
Cellular Receptors ◽  
Model Studies ◽  
Physiological Relevance ◽  
Landing Sites

Humans usually contract dengue by being bitten by arthropods, and more than 3.6 billion people are at risk per year. Although studies are conducted to screen and trace out the possible pathophysiology of the virus, an adequate receptor-based study has not been completed. Understanding how the dengue virus (DV) engraves its landing sites requires identification of such cellular receptors. In many model studies, heparan sulfate (HS) has been reported to act as a DV receptor under various conditions. However, the physiological relevance of these findings remains uncertain. Therefore, it is still unclear whether HS is used by viral strains or not, and if at all used by clinical or non-cell culture-adapted strains of DV. The present review aims to identify relevant experimental evidences that confirm the possible interaction between envelope protein and HS chains. We collected data from a series of studies to conclude the interactive role.

Bacterially expressed and refolded envelope protein (domain III) of dengue virus type-4 binds heparan sulfate

2007 ◽  
Vol 846 (1-2) ◽  
pp. 184-194 ◽  
Author(s):  
Priyabrata Pattnaik ◽  
J. Pradeep Babu ◽  
Shailendra Kumar Verma ◽  
Vijay Tak ◽  
P.V. Lakshmana Rao
Keyword(s):  
Dengue Virus ◽  
Heparan Sulfate ◽  
Virus Type ◽  
Envelope Protein ◽  
Protein Domain ◽  
Domain Iii

scholarly journals Mutation of the dengue virus type 2 envelope protein heparan sulfate binding sites or the domain III lateral ridge blocks replication in Vero cells prior to membrane fusion

Virology ◽  
2013 ◽  
Vol 441 (2) ◽  
pp. 114-125 ◽  
Author(s):  
John T. Roehrig ◽  
Siritorn Butrapet ◽  
Nathan M. Liss ◽  
Susan L. Bennett ◽  
Betty E. Luy ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Heparan Sulfate ◽  
Membrane Fusion ◽  
Binding Sites ◽  
Envelope Protein ◽  
Vero Cells ◽  
Lateral Ridge ◽  
Domain Iii ◽  
Dengue Virus Type 2

scholarly journals Dengue Virus Capsid Protein Binding to Lipid Droplets and its Inhibition. towards a New Drug Target

2013 ◽  
Vol 104 (2) ◽  
pp. 415a
Author(s):  
Filomena A. Carvalho ◽  
Ivo C. Martins ◽  
Fabiana A. Carneiro ◽  
Iranaia Assunção-Miranda ◽  
André F. Faustino ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Protein Binding ◽  
Capsid Protein ◽  
Drug Target ◽  
Lipid Droplets ◽  
Virus Capsid ◽  
New Drug ◽  
Virus Capsid Protein

Epitopes based drug design for dengue virus envelope protein: A computational approach

2017 ◽  
Vol 71 ◽  
pp. 152-160 ◽  
Author(s):  
Abdul Wadood ◽  
Aamir Mehmood ◽  
Huma Khan ◽  
Muhammad Ilyas ◽  
Ayaz Ahmad ◽  
...  
Keyword(s):  
Drug Design ◽  
Dengue Virus ◽  
Envelope Protein ◽  
Protein A ◽  
Computational Approach ◽  
Virus Envelope ◽  
Virus Envelope Protein
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