Novel nano-drug delivery approach for breast cancer

For mitochondria-targeted nano-drug delivery systems against cancer, effectively targeting and releasing the drug into mitochondria are the keys to improve the therapeutic effect.

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Folic Acid Decorated Zeolitic Imidazolate Framework (ZIF-8) Loaded with Baicalin as a Nano-Drug Delivery System for Breast Cancer Therapy

International Journal of Nanomedicine ◽

10.2147/ijn.s340764 ◽

2021 ◽

Vol Volume 16 ◽

pp. 8337-8352

Author(s):

Xiao Mi ◽

Meigeng Hu ◽

Mingran Dong ◽

Zhihong Yang ◽

Xia Zhan ◽

...

Keyword(s):

Breast Cancer ◽

Drug Delivery ◽

Folic Acid ◽

Cancer Therapy ◽

Drug Delivery System ◽

Delivery System ◽

Breast Cancer Therapy ◽

Zeolitic Imidazolate Framework ◽

Nano Drug Delivery

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Towards a targeted multi-drug delivery approach to improve therapeutic efficacy in breast cancer

Expert Opinion on Drug Delivery ◽

10.1517/17425247.2010.513968 ◽

2010 ◽

Vol 7 (10) ◽

pp. 1159-1173 ◽

Cited By ~ 25

Author(s):

Bin Wang ◽

Jenna M Rosano ◽

Rabe'e Cheheltani ◽

Mohan P Achary ◽

Mohammad F Kiani

Keyword(s):

Breast Cancer ◽

Drug Delivery ◽

Therapeutic Efficacy ◽

Delivery Approach

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DOX-loaded pH-sensitive mesoporous silica nanoparticles coated with PDA and PEG induce pro-death autophagy in breast cancer

RSC Advances ◽

10.1039/c7ra05135b ◽

2017 ◽

Vol 7 (63) ◽

pp. 39641-39650 ◽

Cited By ~ 22

Author(s):

Yanhong Duo ◽

Yang Li ◽

Changke Chen ◽

Baiyun Liu ◽

Xinyu Wang ◽

...

Keyword(s):

Breast Cancer ◽

Drug Delivery ◽

Side Effects ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Cell Uptake ◽

Uptake Efficiency ◽

Chemotherapy Drugs ◽

Nano Drug Delivery

The development of multifunctional nano drug delivery carriers has been one of the most effective and prevailing approaches to overcome drug non-selectivity, low cell uptake efficiency and various side effects of traditional chemotherapy drugs.

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Advances in anti-breast cancer drugs and the application of nano-drug delivery systems in breast cancer therapy

Journal of Drug Delivery Science and Technology ◽

10.1016/j.jddst.2020.101662 ◽

2020 ◽

Vol 57 ◽

pp. 101662 ◽

Cited By ~ 10

Author(s):

Xiaolin Fang ◽

Jiaojiao Cao ◽

Aizong Shen

Keyword(s):

Breast Cancer ◽

Drug Delivery ◽

Cancer Therapy ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Cancer Drugs ◽

Breast Cancer Therapy ◽

Nano Drug Delivery ◽

Breast Cancer Drugs

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Experimental study on nuclear-targeted plasmid-based short hairpin RNA (ShRNA) to hypoxia inducible factor-1α (PshHIF-1α) PshHIF-1α nano-drug carrier system for breast cancer treatment in rats

Materials Express ◽

10.1166/mex.2021.2029 ◽

2021 ◽

Vol 11 (7) ◽

pp. 1045-1050

Author(s):

Gang Sun ◽

Jin Zhang ◽

Shuai Wu ◽

Yun Liu

Keyword(s):

Breast Cancer ◽

Drug Delivery ◽

Flow Cytometry ◽

Drug Delivery System ◽

Delivery System ◽

Cell Apoptosis ◽

Drug Carrier ◽

Carrier System ◽

Nano Drug Delivery ◽

Drug Carrier System

This study was aimed at exploring the regulatory mechanism of auclear-targeted pshHIF-1α nano-drug carrier system (NPNCS) in the treatment of breast cancer in rats. MDA-MB-231 cell was cultured and DJ-1 and PTEN mRNA level was detected by qRT-PCR along with analysis of cell viability by CCK-8 and apoptosis by means of flow cytometry. The rats were assigned into control group, nuclear-targeted pshHIF-1α nanopharmaceutical system treatment group, and nuclear-targeted pshHIF-1α nano-pharmaceutical system+PTEN inhibitor SF1670 group, followed by analysis of cell proliferation by EdU staining, cell apoptosis by flow cytometry, and the levels of DJ-1, PTEN, and p-AKT. Compared with MDA-MB-231 cells treated with NPNCS, cells without intervention showed decreased PTEN and increased DJ-1 level. NPNCS induced cell apoptosis. Administration of nuclear-targeted pshHIF-1α nano-drug delivery system down-regulated DJ-1 and up-regulated PTEN. Combined treatment with SF1670 promoted p-AKT level and decreased the inhibitory effect of NPNCS on p-AKT level. In conclusion, the nuclear-targeted pshHIF-1α nano-drug delivery system down-regulated DJ-1 and exerted a tumor suppressor and pro-apoptotic effect, which wasrelated to p-AKT phosphorylation and up-regulation of PTEN.

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