The Effects of The COMT val108/158met Polymorphism on BOLD Activation During Working Memory, Planning, and Response Inhibition: A Role for The Posterior Cingulate Cortex?

Background: Neurofibromatosis 1 (NF1) is a single-gene neurodevelopmental disorder associated with cognitive and behavioural impairments, particularly with deficits in working memory. This study investigates the cerebral volumetric differences in adolescents with NF1 as compared to typically developing controls and how working memory task performance is associated with these differences. Methods: 31 adolescents aged 11-17 years were compared to age and sex-matched controls. NF1 subjects were assessed using detailed multimodal measurement of working memory at baseline followed by a 3T MR scan. A voxel-based morphometry approach was used to estimate the total and regional gray matter(GM) volumetric differences between the NF1 and control groups. The working memory metrics were subjected to a principal component analysis (PCA) approach. Finally, we examined how the components derived from PCA correlated with the changes in GM volume in the NF1 group, after adjusting for age, sex and total intracranial volume. Results: The NF1 cohort showed increased GM volumes in the thalamus, globus pallidus, caudate, putamen, dorsal midbrain and cerebellum bilaterally as compared to controls. The PCA yielded three independent behavioural components reflecting high memory load, low memory load and auditory working memory. Correlation analyses revealed that increased volume of the inferior lateral parietal cortex was associated with poorer performance on the high working memory load tasks. Increased volume of posterior cingulate cortex, a key component of the default mode network (DMN) was significantly associated with poorer performance on low working memory load tasks. Discussion: This is the first study to examine the neuroanatomical correlates of working memory in NF1 adolescents. Consistent with prior literature we show larger subcortical brain volumes in in the NF1 cohort. The strong association between posterior cingulate cortex volume and performance on low memory load conditions supports previously suggested hypotheses of deficient DMN structural development, which in turn may contribute to the cognitive impairments in NF1.

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Are inhibitory and excitatory neurotransmitter levels in the posterior cingulate cortex associated with MS fatigue?

10.26226/morressier.59a3e8b4d462b8028d89445c ◽

2017 ◽

Author(s):

Karen A. Ribbons

Keyword(s):

Cingulate Cortex ◽

Posterior Cingulate Cortex ◽

Excitatory Neurotransmitter ◽

Posterior Cingulate

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Serum Vitamin D and Cingulate Cortex Thickness in Older Adults: Quantitative MRI of the Brain

Current Alzheimer Research ◽

10.2174/1567205016666191113124356 ◽

2019 ◽

Vol 16 (11) ◽

pp. 1063-1071 ◽

Cited By ~ 1

Author(s):

Gonzague Foucault ◽

Guillaume T Duval ◽

Romain Simon ◽

Olivier Beauchet ◽

Mickael Dinomais ◽

...

Keyword(s):

Older Adults ◽

Vitamin D ◽

Brain Mri ◽

Serum Vitamin ◽

Cingulate Cortex ◽

Posterior Cingulate Cortex ◽

Vitamin D Insufficiency ◽

Anterior Cingulate ◽

Posterior Cingulate ◽

Significant Difference

Background: Vitamin D insufficiency is associated with brain changes, and cognitive and mobility declines in older adults. Method: Two hundred and fifteen Caucasian older community-dwellers (mean±SD, 72.1±5.5years; 40% female) received a blood test and brain MRI. The thickness of perigenual anterior cingulate cortex, midcingulate cortex and posterior cingulate cortex was measured using FreeSurfer from T1-weighted MR images. Age, gender, education, BMI, mean arterial pressure, comorbidities, use of vitamin D supplements or anti-vascular drugs, MMSE, GDS, IADL, serum calcium and vitamin B9 concentrations, creatinine clearance were used as covariables. Results: Participants with vitamin D insufficiency (n=80) had thinner total cingulate thickness than the others (24.6±1.9mm versus 25.3±1.4mm, P=0.001); a significant difference found for all 3 regions. Vitamin D insufficiency was cross-sectionally associated with a decreased total cingulate thickness (β=- 0.49, P=0.028). Serum 25OHD concentration correlated positively with the thickness of perigenual anterior (P=0.011), midcingulate (P=0.013) and posterior cingulate cortex (P=0.021). Conclusion: Vitamin D insufficiency was associated with thinner cingulate cortex in the studied sample of older adults. These findings provide insight into the pathophysiology of cognitive and mobility declines in older adults with vitamin D insufficiency.

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Directed Functional Connectivity of Posterior Cingulate Cortex and Whole Brain in Alzheimer's Disease and Mild Cognitive Impairment

Current Alzheimer Research ◽

10.2174/1567205013666161201201000 ◽

2017 ◽

Vol 14 (6) ◽

pp. 628-635 ◽

Cited By ~ 17

Author(s):

Enyan Yu ◽

Zhengluan Liao ◽

Dewang Mao ◽

Qi Zhang ◽

Gongjun Ji ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Functional Connectivity ◽

Cingulate Cortex ◽

Posterior Cingulate Cortex ◽

Whole Brain ◽

Posterior Cingulate

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Long-term Chinese calligraphic handwriting reshapes the posterior cingulate cortex: A VBM study

PLoS ONE ◽

10.1371/journal.pone.0214917 ◽

2019 ◽

Vol 14 (4) ◽

pp. e0214917

Author(s):

Wen Chen ◽

Chuansheng Chen ◽

Pin Yang ◽

Suyu Bi ◽

Jin Liu ◽

...

Keyword(s):

Cingulate Cortex ◽

Posterior Cingulate Cortex ◽

Posterior Cingulate

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HIV Distal Neuropathic Pain Is Associated with Smaller Ventral Posterior Cingulate Cortex

Pain Medicine ◽

10.1093/pm/pnw180 ◽

2016 ◽

pp. pnw180 ◽

Cited By ~ 2

Author(s):

John R. Keltner ◽

Colm G. Connolly ◽

Florin Vaida ◽

Mark Jenkinson ◽

Christine Fennema-Notestine ◽

...

Keyword(s):

Neuropathic Pain ◽

Cingulate Cortex ◽

Posterior Cingulate Cortex ◽

Posterior Cingulate

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Correlation between Traits of Emotion-Based Impulsivity and Intrinsic Default-Mode Network Activity

Neural Plasticity ◽

10.1155/2017/9297621 ◽

2017 ◽

Vol 2017 ◽

pp. 1-9 ◽

Cited By ~ 11

Author(s):

Jizheng Zhao ◽

Dardo Tomasi ◽

Corinde E. Wiers ◽

Ehsan Shokri-Kojori ◽

Şükrü B. Demiral ◽

...

Keyword(s):

Brain Activity ◽

Low Frequency ◽

Cingulate Cortex ◽

Posterior Cingulate Cortex ◽

Anterior Cingulate ◽

Network Activity ◽

High Risk Behaviors ◽

Posterior Cingulate ◽

Healthy Humans ◽

Dorsolateral Prefrontal

Negative urgency (NU) and positive urgency (PU) are implicated in several high-risk behaviors, such as eating disorders, substance use disorders, and nonsuicidal self-injury behavior. The current study aimed to explore the possible link between trait of urgency and brain activity at rest. We assessed the amplitude of low-frequency fluctuations (ALFF) of the resting-state functional magnetic resonance imaging (fMRI) signal in 85 healthy volunteers. Trait urgency measures were related to ALFF in the lateral orbitofrontal cortex, dorsolateral prefrontal cortex, ventral and dorsal medial frontal cortex, anterior cingulate, and posterior cingulate cortex/precuneus. In addition, trait urgency measures showed significant correlations with the functional connectivity of the posterior cingulate cortex/precuneus seed with the thalamus and midbrain region. These findings suggest an association between intrinsic brain activity and impulsive behaviors in healthy humans.

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