Erratum: Sex Moderates the Effects of the Sorl1 Gene rs2070045 Polymorphism on Cognitive Impairment and Disruption of the Cingulum Integrity in Healthy Elderly

ABSTRACT Background: The Clock Drawing Test (CDT) is a brief cognitive screening tool for dementia. Several different presentation formats and scoring methods for the CDT are available in the literature. Objective: In this study we aimed to compare performance on the free-drawn and "incomplete-copy" versions of the CDT using the same short scoring method in Mild Cognitive Impairment (MCI) and dementia patients, and healthy elderly participants. Methods: 90 participants (controlled for age, sex and education) subdivided into control group (n=20), MCI group (n=30) and dementia group (n=40) (Alzheimer's disease - AD=20; Vascular Dementia - VD=20) were recruited for this study. The participants performed the two CDT versions at different times and a blinded neuropsychologist scored the CDTs using the same scoring system. Results: The scores on the free-drawn version were significantly lower than the incomplete-copy version for all groups. The dementia group had significantly lower scores on the incomplete-copy version of the CDT than the control group. MCI patients did not differ significantly from the dementia or control groups. Performance on the free-drawn copy differed significantly among all groups. Conclusion: The free-drawn CDT version is more cognitively demanding and sensitive for detecting mild/early cognitive impairment. Further evaluation of the diagnostic value (accuracy) of the free-drawn CDT in Brazilian MCI patients is needed.

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Hippocampal adaptation to face repetition in healthy elderly and mild cognitive impairment

Neuropsychologia ◽

10.1016/j.neuropsychologia.2003.11.015 ◽

2004 ◽

Vol 42 (7) ◽

pp. 980-989 ◽

Cited By ~ 63

Author(s):

Sterling C. Johnson ◽

Leslie C. Baxter ◽

Lana Susskind-Wilder ◽

Donald J. Connor ◽

Marwan N. Sabbagh ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Healthy Elderly

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Impaired abstract thinking may discriminate between normal aging and vascular mild cognitive impairment

Arquivos de Neuro-Psiquiatria ◽

10.1590/s0004-282x2010000200005 ◽

2010 ◽

Vol 68 (2) ◽

pp. 179-184 ◽

Cited By ~ 7

Author(s):

Felipe Kenji Sudo ◽

Gilberto Sousa Alves ◽

Carlos Eduardo de Oliveira Alves ◽

Maria Elisa Lanna ◽

Letice Ericeira-Valente ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Cerebrovascular Disease ◽

Cognitive Deficits ◽

Cross Sectional Study ◽

Abstract Thinking ◽

Sectional Study ◽

Cross Sectional ◽

Elderly Individuals ◽

Healthy Elderly

OBJECTIVE: Cerebrovascular disease (CVD) is associated with cognitive deficits. This cross-sectional study examines differences among healthy elderly controls and patients with vascular mild cognitive impairment (VaMCI) and vascular dementia (VaD) in performances on CAMCOG subscales. METHOD: Elderly individuals (n=61) were divided into 3 groups, according to cognitive and neuroimaging status: 16 controls, 20 VaMCI and 25 VaD. VaMCI and VaD individuals scored over 4 points on the Hachinski Ischemic Scale. RESULTS: Significant differences in total CAMCOG scores were observed across the three groups (p<0.001). VaD subjects performed worse than those with VaMCI in most CAMCOG subscales (p<0.001). All subscales showed differences between controls and VaD (p<0.001). Performance on abstract thinking showed difference between VaMCI and controls (p<0.001). CONCLUSION: CAMCOG discriminated controls from VaMCI and VaD. Assessment of abstract thinking may be useful as a screening item for diagnosis of VaMCI.

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Predicting the future development of mild cognitive impairment in the cognitively healthy elderly

10.1101/2020.07.30.227496 ◽

2020 ◽

Author(s):

Bryan Strange ◽

Linda Zhang ◽

Alba Sierra-Marcos ◽

Eva Alfayate ◽

Jussi Tohka ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Verbal Memory ◽

Statistical Tests ◽

Treatment Strategies ◽

Area Under The Curve ◽

Predictive Performance ◽

Healthy Individuals ◽

Healthy Elderly ◽

Out Of Sample

Identifying measures that predict future cognitive impairment in healthy individuals is necessary to inform treatment strategies for candidate dementia-preventative and modifying interventions. Here, we derive such measures by studying converters who transitioned from cognitively normal at baseline to mild-cognitive impairment (MCI) in a longitudinal study of 1213 elderly participants. We first establish reduced grey matter density (GMD) in left entorhinal cortex (EC) as a biomarker for impending cognitive decline in healthy individuals, employing a matched sampling control for several dementia risk-factors, thereby mitigating the potential effects of bias on our statistical tests. Next, we determine the predictive performance of baseline demographic, genetic, neuropsychological and MRI measures by entering these variables into an elastic net-regularized classifier. Our trained statistical model classified converters and controls with validation Area-Under-the-Curve>0.9, identifying only delayed verbal memory and left EC GMD as relevant predictors for classification. This performance was maintained on test classification of out-of-sample converters and controls. Our results suggest a parsimonious but powerful predictive model for MCI development in the cognitively healthy elderly.

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SORL1 Gene is Associated with the Conversion from Mild Cognitive Impairment to Alzheimer’s Disease

Journal of Alzheimer s Disease ◽

10.3233/jad-141551 ◽

2015 ◽

Vol 46 (3) ◽

pp. 771-776 ◽

Cited By ~ 8

Author(s):

Paola Piscopo ◽

Giuseppe Tosto ◽

Chiara Belli ◽

Giuseppina Talarico ◽

Daniela Galimberti ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Sorl1 Gene

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[P2-285]: SELF-EVALUATION OF DRIVING ABILITY THROUGH A DRIVING SIMULATOR EXPERIMENT: DIFFERENCES BETWEEN PATIENTS WITH MILD COGNITIVE IMPAIRMENT (MCI) AND HEALTHY ELDERLY DRIVERS

Alzheimer s & Dementia ◽

10.1016/j.jalz.2017.06.938 ◽

2017 ◽

Vol 13 (7S_Part_15) ◽

pp. P724-P724 ◽

Cited By ~ 1

Author(s):

Stella Fragkiadaki ◽

Dionysia Kontaxopoulou ◽

Ion N. Beratis ◽

Dimosthenis Pavlou ◽

Nikolaos Andronas ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Driving Simulator ◽

Driving Ability ◽

Self Evaluation ◽

Elderly Drivers ◽

Healthy Elderly

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Validity of a novel computerized screening test system for mild cognitive impairment

International Psychogeriatrics ◽

10.1017/s1041610218000923 ◽

2018 ◽

Vol 30 (10) ◽

pp. 1455-1463 ◽

Cited By ~ 5

Author(s):

Jin-Hyuck Park ◽

Minye Jung ◽

Jongbae Kim ◽

Hae Yean Park ◽

Jung-Ran Kim ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Elderly People ◽

Predictive Value ◽

Screening Test ◽

Concurrent Validity ◽

Test System ◽

Screening Tests ◽

Validity And Reliability ◽

Healthy Elderly

ABSTRACTBackground:The mobile screening test system for screening mild cognitive impairment (mSTS-MCI) was developed for clinical use. However, the clinical usefulness of mSTS-MCI to detect elderly with MCI from those who are cognitively healthy has yet to be validated. Moreover, the comparability between this system and traditional screening tests for MCI has not been evaluated.Objective:The purpose of this study was to examine the validity and reliability of the mSTS-MCI and confirm the cut-off scores to detect MCI.Method:The data were collected from 107 healthy elderly people and 74 elderly people with MCI. Concurrent validity was examined using the Korean version of Montreal Cognitive Assessment (MoCA-K) as a gold standard test, and test–retest reliability was investigated using 30 of the study participants at four-week intervals. The sensitivity, specificity, positive predictive value, and negative predictive value (NPV) were confirmed through Receiver Operating Characteristic (ROC) analysis, and the cut-off scores for elderly people with MCI were identified.Results:Concurrent validity showed statistically significant correlations between the mSTS-MCI and MoCA-K and test–rests reliability indicated high correlation. As a result of screening predictability, the mSTS-MCI had a higher NPV than the MoCA-K.Conclusions:The mSTS-MCI was identified as a system with a high degree of validity and reliability. In addition, the mSTS-MCI showed high screening predictability, indicating it can be used in the clinical field as a screening test system for mild cognitive impairment.

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Performance of a sample of patients with Mild Cognitive Impairment (MCI), Alzheimer's Disease (AD) and healthy elderly on a lexical decision test (LDT) as a measure of pre-morbid intelligence

Dementia & Neuropsychologia ◽

10.1590/1980-57642015dn93000009 ◽

2015 ◽

Vol 9 (3) ◽

pp. 265-269 ◽

Cited By ~ 1

Author(s):

Valéria Trunkl Serrao ◽

Sônia Maria Dozzi Brucki ◽

Kenia Repiso Campanholo ◽

Letícia Lessa Mansur ◽

Ricardo Nitrini ◽

...

Keyword(s):

Cognitive Impairment ◽

Lexical Decision ◽

Test Methods ◽

Elderly Subjects ◽

Boston Naming Test ◽

Brazilian Sample ◽

Healthy Elderly ◽

Matrix Reasoning ◽

Naming Test ◽

Healthy Elderly Subjects

Objective: The objective of this study was to describe the performance of healthy elderly patients with aging-related pathologies (MCI) and patients with AD on a lexical decision test. Methods: The study included 38 healthy elderly subjects, 61 MCI and 26 AD patients from the Neurology Department of the Hospital das Clinicas, Behavioral and Cognitive Neurology Group. The neuropsychological instruments included the episodic memory test (RAVLT), subtests from the WAIS-III (Matrix Reasoning and Vocabulary) to determine estimated IQ, the Boston naming test (BNT) and Lexical Decision Test (LDT). Results: All groups differed on the MMSE, as expected according to their pathologies, memory tests, naming and estimated IQ. For the vocabulary and the LDT - measures of crystalized intelligence no differences were found. Conclusion: The LDT demonstrated that lexical decision can be used as a measure of pre-morbid IQ among the individuals assessed in a Brazilian sample.

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