A case of adrenaline-predominant paraganglioma diagnosed with a state of shock after glucagon injection

2020 ◽  
Vol 43 (5) ◽  
pp. 473-475 ◽  
Author(s):  
Hiroshi Nakama ◽  
Mitsuhiro Okamoto ◽  
Keiko Kurosawa ◽  
Hiromitsu Mimata ◽  
Tsutom Daa ◽  
...  
Keyword(s):  
Glucagon Injection

Doppler sonography measurement of portal blood flow velocity after glucagon injection in patients with chronic HCV infection

2001 ◽  
Vol 27 (5) ◽  
pp. 723-726 ◽  
Author(s):  
Silvia Sereno ◽  
Fabrizio Toccaceli ◽  
Vincenzo Russo ◽  
Fabio Iacomi ◽  
Enrico Maria Zardi ◽  
...  
Keyword(s):  
Blood Flow ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Doppler Sonography ◽  
Portal Blood Flow ◽  
Hcv Infection ◽  
Portal Blood ◽  
Chronic Hcv Infection ◽  
Glucagon Injection ◽  
Chronic Hcv

scholarly journals Identity of isoenzyme 1 of histidine-pyruvate aminotransferase with serine-pyruvate aminotransferase

1976 ◽  
Vol 159 (3) ◽  
pp. 607-613 ◽  
Author(s):  
T Noguchi ◽  
E Okuno ◽  
R Kido
Keyword(s):  
Amino Acids ◽  
Pyridoxal Phosphate ◽  
Competitive Inhibitor ◽  
Mitochondrial Fraction ◽  
Constant Ratio ◽  
Absorbance Maximum ◽  
Glucagon Injection

After glucagon injection, rats showed virtually identical percentage increases in hepatic histidine-pyruvate aminotransferase and serine-pyruvate aminotransferase activities, both in the mitochondria and in the cytosol. Histidine-pyruvate aminotransferase isoenzyme 1, with pI8.0, was purified to homogeneity from the mitochondrial fraction of liver from glucagon-injected rats. The purified enzyme catalysed transamination between a number of amino acids and pyruvate or phenylpyruvate. For transamination with pyruvate, the activity with serine reached a constant ratio to that with histidine during purification, which was unchanged by a variety of treatments of the purified enzyme. Serine was found to act as a competitive inhibitor of histidine transamination, and histidine of serine transamination. These results suggest that histidine-pyruvate amino-transferase isoenzymes 1 is identical with serine-pyruvate aminotransferase. The enzyme is probably composed of two identical subunits with mol. wt. approx. 38000. The absorbance maximum at 410 nm and the inhibition by carbonyl reagents strongly indicate the presence of pyridoxal phosphate.

Two daily glucagon injections induce nonshivering thermogenesis in Muscovy ducklings

1987 ◽  
Vol 252 (5) ◽  
pp. E616-E620 ◽  
Author(s):  
H. Barre ◽  
F. Cohen-Adad ◽  
J. L. Rouanet
Keyword(s):  
Body Temperature ◽  
Metabolic Rate ◽  
Ambient Temperature ◽  
Cold Acclimation ◽  
Saline Control ◽  
Nonshivering Thermogenesis ◽  
Control Value ◽  
Glucagon Injection ◽  
Significant Change

In 6-wk-old chronically glucagon-treated (GT) ducklings, the calorigenic effect of intraperitoneal test injection of glucagon was measured at 25 and 4 degrees C ambient temperature (Ta). At 25 degrees C Ta, the increase in metabolic rate (MR) due to test injection of glucagon (360 micrograms/kg) reached 5.3 W/kg (i.e., 98% above the saline control value) in GT ducklings and only 1.7 W/kg (i.e., 29% above the control value) in control (TN) ducklings. After the injection, GT ducklings developed a hyperthermia, reaching 2.4 degrees C, accompanied by intense panting, whereas thermal body temperature did not change in TN ducklings. At 4 degrees C Ta for the same dose of glucagon, no significant change in MR was observed in GT ducklings during 180 min of exposure, whereas a 25% decrease in MR occurred in the same conditions in TN ducklings. In the cold, glucagon injection inhibited shivering in both groups of ducklings but thermogenesis was not suppressed in GT ducklings, showing a true nonshivering thermogenesis in these birds. This nonshivering thermogenesis was estimated to be 3 W/kg (i.e., 55% above resting MR). Such changes produced by chronic glucagon treatment resemble the artificial cold acclimation of rats chronically treated by norepinephrine.

Glucagon injection for type 1 diabetes in children

2011 ◽  
Vol 23 (9) ◽  
pp. 12-18 ◽  
Author(s):  
Diana Yardley ◽  
Anne Lyddall ◽  
Julie Richardson ◽  
Helen Timms ◽  
Jane Edwards ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glucagon Injection

Lowering of serum T3 and rise in reverse T3 induced by glucagon infusion in anaesthetized dogs

1987 ◽  
Vol 116 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Udaya M. Kabadi ◽  
Lester Dragstedt
Keyword(s):  
Normal Saline ◽  
Normal Subjects ◽  
Reverse T3 ◽  
Significant Fall ◽  
Before And After ◽  
Serum T3 ◽  
Saline Administration ◽  
Glucagon Injection ◽  
Control Study

Abstract. We recently demonstrated that lowering of T3 and a rise in rT3 observed in non-thyroidal illnesses could be induced by glucagon infusion in normal subjects without altering T4, Free T4 (FT4) and T3 resin uptake (T3RU) values suggesting that altered T4 metabolism may be mainly responsible for those changes. To further assess the role of altered T4 metabolism in these changes during induction of hyperglucagonaemia, we studied glucose, T4, FT4, T3RU, T3, and rT3 concentrations before and after iv glucagon injection (0.5 mg) for up to 3 h in 6 anaesthetized dogs, since thyroxinebinding globulin (TBG) concentration is known to be extremely low in dogs. A control study was conducted with iv normal saline (0.5 ml) injection. T4, FT4 and T3RU remained unchanged during both studies. A significant fall was noted in T3 with glucagon (ΔT3, 0.23 ± 0.06 nmol/l vs 0 ± 0.03 nmol/l with normal saline; P < 0.01). rT3 rose markedly following glucagon infusion (ΔrT3, 0.04 ± 0.011 nmol/l vs −0.017 ± 0.006 nmol/l with normal saline; P < 0.01). Moreover, areas under the curves for T3 and rT3 were markedly increased during glucagon infusion when compared to saline administration (P < 0.01 for both comparisons). Therefore, this study suggests that changes in T3 and rT3 concentrations observed in non-thyroidal illnesses may be attributed to hyperglucagonaemia and may be secondary to altered T4 metabolism as reflected by lowered T3/T4 and increased rT3/T4 ratio.

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