Peroxisome inspired hybrid enzyme nanogels for chemodynamic and photodynamic therapy

AbstractPeroxisome, a special cytoplasmic organelle, possesses one or more kinds of oxidases for hydrogen peroxide (H2O2) production and catalase for H2O2 degradation, which serves as an intracellular H2O2 regulator to degrade toxic peroxides to water. Inspired by this biochemical pathway, we demonstrate the reactive oxygen species (ROS) induced tumor therapy by integrating lactate oxidase (LOx) and catalase (CAT) into Fe3O4 nanoparticle/indocyanine green (ICG) co-loaded hybrid nanogels (designated as FIGs-LC). Based on the O2 redistribution and H2O2 activation by cascading LOx and CAT catalytic metabolic regulation, hydroxyl radical (·OH) and singlet oxygen (1O2) production can be modulated for glutathione (GSH)-activated chemodynamic therapy (CDT) and NIR-triggered photodynamic therapy (PDT), by manipulating the ratio of LOx and CAT to catalyze endogenous lactate to produce H2O2 and further cascade decomposing H2O2 into O2. The regulation reactions of FIGs-LC significantly elevate the intracellular ROS level and cause fatal damage to cancer cells inducing the effective inhibition of tumor growth. Such enzyme complex loaded hybrid nanogel present potential for biomedical ROS regulation, especially for the tumors with different redox state, size, and subcutaneous depth.

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Dinuclear phosphorescent rhenium(i) complexes as potential anticancer and photodynamic therapy agents

Dalton Transactions ◽

10.1039/d0dt02424d ◽

2020 ◽

Vol 49 (33) ◽

pp. 11583-11590 ◽

Cited By ~ 2

Author(s):

Zheng-Yin Pan ◽

Dai-Hong Cai ◽

Liang He

Keyword(s):

Photodynamic Therapy ◽

Cell Apoptosis ◽

Lysosomal Dysfunction ◽

Intracellular Ros

Two dinuclear organometallic Re(i) complexes increase intracellular ROS levels, causing lysosomal dysfunction and cell apoptosis.

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Photoactive conjugated polymer/graphdiyne nanocatalyst for CO2 reduce into CO in living cells for hypoxia tumor treatment

Materials Chemistry Frontiers ◽

10.1039/d1qm00677k ◽

2021 ◽

Author(s):

Endong Zhang ◽

Zicheng Zuo ◽

Wen Yu ◽

Hao Zhao ◽

Shengpeng Xia ◽

...

Keyword(s):

Carbon Monoxide ◽

Photodynamic Therapy ◽

Tumor Microenvironment ◽

Conjugated Polymer ◽

Tumor Therapy ◽

Living Cells ◽

Tumor Treatment ◽

Treatment Efficiency ◽

Therapy Strategy ◽

Co Gas

Carbon monoxide (CO) gas therapy has grown to be an emerging tumor therapy strategy to avoid low treatment efficiency of photodynamic therapy (PDT) caused by the hypoxia tumor microenvironment. However,...

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new bIologIcal model of moderate InhIbItIon of tumor and metastases growth wIth prolonged leukopenIa In mIce

Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук ◽

10.12737/23406 ◽

2016 ◽

Vol 1 (5) ◽

pp. 121-125

Author(s):

Зуева ◽

Elena Zueva ◽

Разина ◽

Tatyana Razina ◽

Ермакова ◽

...

Keyword(s):

Tumor Growth ◽

Lung Carcinoma ◽

Lewis Lung Carcinoma ◽

Tumor Therapy ◽

Biological Model ◽

Tumor Growth Inhibition ◽

Lewis Lung ◽

Inhibition Of Tumor Growth ◽

Toxic Manifestation ◽

Cyclophosphamide Dose

A new biological model of moderate inhibition of tumor growth and metastases with prolonged leukopenia on C57Bl/6 mice with the Lewis Lung Carcinoma was designed. The model was created by the injection of cyclophosphamide (dose 83.3mg/kg) on 6th, 12th, 18th days after tumor cells transplantation on animals. Experiment showed that 3-fold cyclo-phosphamide use leads to growth of primary tumor and metastases inhibition. Tumor growth inhibition was 34% on 21st day after cyclophosphamide inject. The number of metastases decreased by 4.7times (p<0,01). Metastatic area reduced. Metastasis frequency made 100%. In addition, the course of cyclophosphamide application caused inhibition of granulocytic and lymphoid hematopoiesis. The reducing the number of segmented neutrophils and lymphocytes was showed on the 3rd day after 1, 2 and 3 injections of cyclophosphamide. The model can be used to study the efficacy of drugs in tumor therapy and in correction of such toxic manifestation of chemotherapy as leukopenia.

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Responsive agarose hydrogel incorporated with natural humic acid and MnO2 nanoparticles for effective relief of tumor hypoxia and enhanced photo-induced tumor therapy

Biomaterials Science ◽

10.1039/c9bm01472a ◽

2020 ◽

Vol 8 (1) ◽

pp. 353-369 ◽

Cited By ~ 5

Author(s):

Mengmeng Hou ◽

Weiwei Liu ◽

Lei Zhang ◽

Leiyang Zhang ◽

Zhigang Xu ◽

...

Keyword(s):

Photodynamic Therapy ◽

Humic Acid ◽

Tumor Microenvironment ◽

Tumor Therapy ◽

Tumor Hypoxia ◽

Therapeutic Outcome ◽

Severe Hypoxia ◽

Tumor Penetration ◽

Mno2 Nanoparticles ◽

Agarose Hydrogel

In spite of widespread applications of nano-photosensitizers, poor tumor penetration and severe hypoxia in the tumor microenvironment (TME) always result in an undesirable therapeutic outcome of photodynamic therapy (PDT).

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Antitumor immunity triggered by photothermal therapy and photodynamic therapy of a 2D MoS2 nanosheet-incorporated injectable polypeptide-engineered hydrogel combinated with chemotherapy for 4T1 breast tumor therapy

Nanotechnology ◽

10.1088/1361-6528/ab72b9 ◽

2020 ◽

Vol 31 (20) ◽

pp. 205102 ◽

Cited By ~ 2

Author(s):

Ruimei Jin ◽

Jie Yang ◽

Pengchu Ding ◽

Chaoqing Li ◽

Bin Zhang ◽

...

Keyword(s):

Photodynamic Therapy ◽

Breast Tumor ◽

Photothermal Therapy ◽

Antitumor Immunity ◽

Tumor Therapy ◽

Mos2 Nanosheet

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Stable supramolecular porphyrin@albumin nanoparticles for optimal photothermal activity

Materials Chemistry Frontiers ◽

10.1039/c9qm00387h ◽

2019 ◽

Vol 3 (9) ◽

pp. 1892-1899 ◽

Cited By ~ 4

Author(s):

Xiaohua Zheng ◽

Lei Wang ◽

Zhitao Lei ◽

Qing Pei ◽

Shi Liu ◽

...

Keyword(s):

Tumor Growth ◽

Conversion Efficiency ◽

Photothermal Conversion ◽

Albumin Nanoparticles ◽

Effective Inhibition ◽

Inhibition Of Tumor Growth ◽

Nanoparticle Formulation

A stable nanoparticle formulation is constructed from porphyrin and albumin, which possesses robust photostability, a high photothermal conversion efficiency and effective inhibition of tumor growth.

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Iron-based nanoparticles for MR imaging-guided ferroptosis in combination with photodynamic therapy to enhance cancer treatment

Nanoscale ◽

10.1039/d0nr08757b ◽

2021 ◽

Vol 13 (9) ◽

pp. 4855-4870

Author(s):

Qifang Chen ◽

Xianbin Ma ◽

Li Xie ◽

Wenjie Chen ◽

Zhigang Xu ◽

...

Keyword(s):

Photodynamic Therapy ◽

Mr Imaging ◽

Cancer Treatment ◽

Antitumor Effects ◽

Therapy Strategy ◽

Intracellular Ros ◽

Iron Based

MR imaging-guided a synergistic ferroptosis-photodynamic therapy strategy can enhance antitumor effects by accumulating intracellular ROS through the utilization of iron-based nanoparticles.

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Photoacoustic Imaging Application in Tumor Diagnosis and Treatment Monitoring

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.364-366.1100 ◽

2007 ◽

Vol 364-366 ◽

pp. 1100-1104 ◽

Cited By ~ 1

Author(s):

Liang Zhong Xiang ◽

Fei Fan Zhou

Keyword(s):

Photodynamic Therapy ◽

Photoacoustic Imaging ◽

Tumor Therapy ◽

Single Pulse ◽

Treatment Monitoring ◽

Tumor Diagnosis ◽

Diagnosis And Treatment ◽

Imaging Application ◽

Early Tumor

Photoacoustic imaging (also called optoacoustic or thermoacoustic imaging) can image vascularity clearly with simultaneous high contrast and high spatial resolution, and has the potential to be an application for tumor diagnosis and treatment monitoring. In a unique photoacoustic system, a single pulse laser beam was used as the light source for both cancer treatment and for concurrently generating ultrasound signals for photoacoustic imaging. The photoacoustic system was used to detect early tumor on the rat back, and the vascular structure around the tumor could be imaged clearly with optimal contrast. This system was also used to monitoring damage of the vascular structures before, during and after photodynamic therapy of tumor. This work demonstrates that photoacoustic imaging can potentially be used to guide photodynamic therapy and other phototherapies using vascular changes during treatment. Prospective application of photoacoustic imaging is to characterize and monitor the accumulation of gold nanoshells in vivo to guide nanoshell-based thermal tumor therapy.

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A photo and tumor microenvironment activated nano-enzyme with enhanced ROS generation and hypoxia relief for efficient cancer therapy

Journal of Materials Chemistry B ◽

10.1039/d1tb01437d ◽

2021 ◽

Vol 9 (39) ◽

pp. 8253-8262

Author(s):

Yali Chen ◽

Yujun Cai ◽

Xingsu Yu ◽

Hong Xiao ◽

Haozhe He ◽

...

Keyword(s):

Reactive Oxygen Species ◽

Photodynamic Therapy ◽

Tumor Microenvironment ◽

Cancer Therapy ◽

Tumor Therapy ◽

Reactive Oxygen ◽

Ros Generation ◽

Oxygen Species ◽

Therapy Strategies

Reactive oxygen species (ROS) mediated tumor therapy strategies have exhibited great prospects and attracted increasing attention, among which photodynamic therapy (PDT) has been well-established.

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