scholarly journals A novel nairovirus associated with acute febrile illness in Hokkaido, Japan

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Fumihiro Kodama ◽  
Hiroki Yamaguchi ◽  
Eunsil Park ◽  
Kango Tatemoto ◽  
Mariko Sashika ◽  
...  
Keyword(s):  
Public Health ◽  
Ixodes Ricinus ◽  
Febrile Illness ◽  
Hemorrhagic Fever ◽  
Tick Bite ◽  
Acute Febrile Illness ◽  
Causative Pathogen ◽  
Crimean Congo Hemorrhagic Fever ◽  
Global Concern ◽  
Wild Deer

AbstractThe increasing burden of tick-borne orthonairovirus infections, such as Crimean-Congo hemorrhagic fever, is becoming a global concern for public health. In the present study, we identify a novel orthonairovirus, designated Yezo virus (YEZV), from two patients showing acute febrile illness with thrombocytopenia and leukopenia after tick bite in Hokkaido, Japan, in 2019 and 2020, respectively. YEZV is phylogenetically grouped with Sulina virus detected in Ixodes ricinus ticks in Romania. YEZV infection has been confirmed in seven patients from 2014–2020, four of whom were co-infected with Borrelia spp. Antibodies to YEZV are found in wild deer and raccoons, and YEZV RNAs have been detected in ticks from Hokkaido. In this work, we demonstrate that YEZV is highly likely to be the causative pathogen of febrile illness, representing the first report of an endemic infection associated with an orthonairovirus potentially transmitted by ticks in Japan.

scholarly journals Differential Laboratory Diagnosis of Acute Fever in Guinea: Preparedness for the Threat of Hemorrhagic Fevers

2021 ◽  
Vol 18 (11) ◽  
pp. 6022
Author(s):  
Vladimir G. Dedkov ◽  
N’Faly Magassouba ◽  
Olga A. Stukolova ◽  
Victoria A. Savina ◽  
Jakob Camara ◽  
...  
Keyword(s):  
Ebola Virus ◽  
Febrile Illness ◽  
Laboratory Diagnosis ◽  
Acute Febrile Illness ◽  
Causative Pathogen ◽  
Hemorrhagic Fevers ◽  
Wide Range ◽  
Causative Agents ◽  
Pathognomonic Sign

Acute febrile illnesses occur frequently in Guinea. Acute fever itself is not a unique, hallmark indication (pathognomonic sign) of any one illness or disease. In the infectious disease context, fever’s underlying cause can be a wide range of viral or bacterial pathogens, including the Ebola virus. In this study, molecular and serological methods were used to analyze samples from patients hospitalized with acute febrile illness in various regions of Guinea. This analysis was undertaken with the goal of accomplishing differential diagnosis (determination of causative pathogen) in such cases. As a result, a number of pathogens, both viral and bacterial, were identified in Guinea as causative agents behind acute febrile illness. In approximately 60% of the studied samples, however, a definitive determination could not be made.

The impact of Crimean-Congo hemorrhagic fever virus on public health

2013 ◽  
Vol 98 (2) ◽  
pp. 248-260 ◽  
Author(s):  
Marc Mertens ◽  
Katja Schmidt ◽  
Aykut Ozkul ◽  
Martin H. Groschup
Keyword(s):  
Public Health ◽  
Hemorrhagic Fever ◽  
Fever Virus ◽  
Crimean Congo Hemorrhagic Fever ◽  
Hemorrhagic Fever Virus ◽  
The Impact

scholarly journals RIG-I Mediates an Antiviral Response to Crimean-Congo Hemorrhagic Fever Virus

2015 ◽  
Vol 89 (20) ◽  
pp. 10219-10229 ◽  
Author(s):  
Jessica R. Spengler ◽  
Jenish R. Patel ◽  
Ayan K. Chakrabarti ◽  
Marko Zivcec ◽  
Adolfo García-Sastre ◽  
...  
Keyword(s):  
Public Health ◽  
Rna Virus ◽  
Hemorrhagic Fever ◽  
Antiviral Response ◽  
Fever Virus ◽  
Type I ◽  
Immune Recognition ◽  
Crimean Congo Hemorrhagic Fever ◽  
Hemorrhagic Fever Virus ◽  
Significant Public Health

ABSTRACTIn the cytoplasm, the retinoic acid-inducible gene I (RIG-I) senses the RNA genomes of several RNA viruses. RIG-I binds to viral RNA, eliciting an antiviral response via the cellular adaptor MAVS. Crimean-Congo hemorrhagic fever virus (CCHFV), a negative-sense RNA virus with a 5′-monophosphorylated genome, is a highly pathogenic zoonotic agent with significant public health implications. We found that, during CCHFV infection, RIG-I mediated a type I interferon (IFN) response via MAVS. Interfering with RIG-I signaling reduced IFN production and IFN-stimulated gene expression and increased viral replication. Immunostimulatory RNA was isolated from CCHFV-infected cells and from virion preparations, and RIG-I coimmunoprecipitation of infected cell lysates isolated immunostimulatory CCHFV RNA. This report serves as the first description of a pattern recognition receptor for CCHFV and highlights a critical signaling pathway in the antiviral response to CCHFV.IMPORTANCECCHFV is a tick-borne virus with a significant public health impact. In order for cells to respond to virus infection, they must recognize the virus as foreign and initiate antiviral signaling. To date, the receptors involved in immune recognition of CCHFV are not known. Here, we investigate and identify RIG-I as a receptor involved in initiating an antiviral response to CCHFV. This receptor initially was not expected to play a role in CCHFV recognition because of characteristics of the viral genome. These findings are important in understanding the antiviral response to CCHFV and support continued investigation into the spectrum of potential viruses recognized by RIG-I.

scholarly journals Prospective Assessment of the Etiology of Acute Febrile Illness after a Tick Bite in Slovenia

2001 ◽  
Vol 33 (4) ◽  
pp. 503-510 ◽  
Author(s):  
Stanka Lotrič‐Furlan ◽  
Miroslav Petrovec ◽  
Tatjana Avsic‐Zupanc ◽  
William L. Nicholson ◽  
John W. Sumner ◽  
...  
Keyword(s):  
Febrile Illness ◽  
Tick Bite ◽  
Acute Febrile Illness ◽  
Prospective Assessment

Follow-up of patients with tick bite in terms of Crimean Congo hemorrhagic fever: Is tick bite enough for diagnosis?

2014 ◽  
Vol 20 (4) ◽  
pp. 309
Author(s):  
Samil Hizli ◽  
Hulya Sertoz ◽  
Mesut Kocak ◽  
Aydin Celik ◽  
Gonca Yilmaz
Keyword(s):  
Hemorrhagic Fever ◽  
Tick Bite ◽  
Crimean Congo Hemorrhagic Fever

scholarly journals Dengue Typhoid Co-infection: a New Threat

2019 ◽  
Vol 10 (1) ◽  
pp. 96-97
Author(s):  
Md Mahmudur Rahman Siddiqui ◽  
Quazi Tarikul Islam ◽  
Mohammad Shahidul Islam
Keyword(s):  
Public Health ◽  
Developing Countries ◽  
Typhoid Fever ◽  
Dengue Fever ◽  
Clinical Diagnosis ◽  
Clinical Presentation ◽  
Febrile Illness ◽  
Acute Febrile Illness ◽  
Medical College ◽  
Common Clinical Presentation

Acute febrile illness is the most common clinical presentation among patients attending to doctor in developing countries. In Bangladesh, dengue and typhoid fever have emerged as major public health problems. Co-infection with both these diseases is rarely reported and are known to present with overlapping symptoms making the clinical diagnosis difficult. The exact incidence of dengue and typhoid co-infection is not known. Here we report a case of co-infection of dengue fever with typhoid fever. Anwer Khan Modern Medical College Journal Vol. 10, No. 1: Jan 2019, P 96-97

Hemorrhagic Fever with Renal Syndrome and Crimean-Congo Hemorrhagic Fever as Causes of Acute Undifferentiated Febrile Illness in Bulgaria

2013 ◽  
Vol 13 (3) ◽  
pp. 188-192 ◽  
Author(s):  
Iva Christova ◽  
Rasha Younan ◽  
Evgenia Taseva ◽  
Teodora Gladnishka ◽  
Iva Trifonova ◽  
...  
Keyword(s):  
Febrile Illness ◽  
Hemorrhagic Fever ◽  
Crimean Congo Hemorrhagic Fever

scholarly journals Immunocompetent mouse model for Crimean-Congo hemorrhagic fever virus

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
David W Hawman ◽  
Kimberly Meade-White ◽  
Shanna Leventhal ◽  
Friederike Feldmann ◽  
Atsushi Okumura ◽  
...  
Keyword(s):  
Mouse Model ◽  
Severe Disease ◽  
Case Fatality ◽  
Febrile Illness ◽  
Hemorrhagic Fever ◽  
Fever Virus ◽  
Type I ◽  
Crimean Congo Hemorrhagic Fever ◽  
Hemorrhagic Fever Virus ◽  
Viral Determinants

Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne febrile illness with wide geographic distribution. CCHF is caused by infection with the Crimean-Congo hemorrhagic fever virus (CCHFV) and case fatality rates can be as high as 30%. Despite causing severe disease in humans, our understanding of the host and viral determinants of CCHFV pathogenesis are limited. A major limitation in the investigation of CCHF has been the lack of suitable small animal models. Wild-type mice are resistant to clinical isolates of CCHFV and consequently, mice must be deficient in type I interferon responses to study the more severe aspects of CCHFV. We report here a mouse-adapted variant of CCHFV that recapitulates in adult, immunocompetent mice the severe CCHF observed in humans. This mouse-adapted variant of CCHFV significantly improves our ability to study host and viral determinants of CCHFV-induced disease in a highly tractable mouse model.

scholarly journals Report of the Crimean Congo hemorrhagic fever in Abadan, Iran: Summer 2016 (Case Report)

2020 ◽  
Author(s):  
Ali Asghar Valipour ◽  
Azimeh Karimyan ◽  
Maghsud Piri ◽  
Dariush Bahrami ◽  
Fatemeh Hallajian ◽  
...  
Keyword(s):  
Public Health ◽  
Case Report ◽  
Severe Disease ◽  
Hemorrhagic Fever ◽  
Viral Disease ◽  
Mortality Rates ◽  
Sudden Onset ◽  
Infected Blood ◽  
Crimean Congo Hemorrhagic Fever ◽  
Health Measures

Abstract Crimean-Congo Hemorrhagic Fever (CCHF) is a tick-borne, viral disease that may also be transmitted through person-to-person transmission by exposure to infected body fluids. It causes a severe disease in humans with high mortality rates. Here we present two cases of CCHF patients with sudden onset of lethargy, fever, nausea, vomiting, headache, and hemorrhagic manifestation. With one of the patients tick bite was confirmed, then he was treated with ribavirin in isolation and recovered completely. The second patient was in contact with the infected blood of a sheep and, unfortunately, despite the treatment, he passed away. Public health measures should focus on preventing this infection by raising the awareness of CCHF symptoms and route of its transmission, and also by adopting practices to decrease the chances of spreading infections in hospitals.

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