scholarly journals Case-control study of hypertension and Parkinson’s disease

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yuen-Fann Ng ◽  
Ebonne Ng ◽  
Ee-Wei Lim ◽  
Kumar M. Prakash ◽  
Louis C. S. Tan ◽  
...  

AbstractWe evaluate the association of hypertension with PD in an Asian population and performed a meta-analysis on similar studies to address the effect of hypertension on PD risk. A matched case-control study involving 1342 Chinese subjects (671 PD and 671 age and gender-matched controls (with a mean age of 63.9 ± 9.7 and 63.5 ± 9.8 years, and identical proportion of gender distribution) was conducted. Hypertension increases PD risk by 1.9 times [OR 1.86 (1.46–2.38)]. The literature search identified 618 studies initially; however, only three matched case-control studies (all in Caucasians) met the inclusion criteria for meta-analysis. Overall analysis showed that hypertension decreases PD risk by 0.2 times [OR 0.80 (0.66–0.96)]. Hypertension increases PD risk by 1.9 times in our Asian population. However, a meta-analysis comprising of Caucasian populations showed a protective effect of hypertension suggesting that ethnic differences or other genetic or environmental factors may contribute to the divergent observation. Early diagnosis and treatment of hypertension may potentially reduce the risk of PD, at least in our population.

2018 ◽  
Vol 58 (4) ◽  
pp. 1203-1216 ◽  
Author(s):  
Rohoullah Hemmati ◽  
Zeinab Bidel ◽  
Milad Nazarzadeh ◽  
Maryam Valadi ◽  
Somayeh Berenji ◽  
...  

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Aus Molan ◽  
Kazunori Nosaka ◽  
Michael Hunter ◽  
Jinxia Zhang ◽  
Xiaoni Meng ◽  
...  

An emerging field of research is starting to examine the association of infectious pathogens with type 2 diabetes mellitus (T2DM). An understudied parasite of interest is Toxoplasma gondii. Globally, very few studies have been conducted to investigate this association. Additionally, very little data exists on the prevalence of T. gondii in the general Australian population. Our group sought to determine the prevalence, association, and risk factors between T. gondii infection and T2DM from a representative Australian human population. Through a cross-sectional, age- and gender-matched case-control study, 150 subjects with T2DM together with 150 control subjects from the Busselton Health Study cohort were investigated. Sera samples were tested for the presence of anti-T. gondii IgG and IgM antibodies using enzyme-linked immunosorbent assays. Survey-derived data were also analyzed to evaluate associated risk factors. The IgG seroprevalence was found to be 62% and 66% for the T2DM and control groups, respectively (OR:0.84; p=0.471). IgM antibodies were detected in 5% of the T2DM patients and in 10% of the controls (OR=0.51; p=0.135). There were no significant differences between male and female IgG seroprevalence rates for both groups (OR:0.88, 0.80; p=0.723). The IgG seropositivity rate increased significantly in T2DM patients aged 45-84 years in comparison to those aged 18-44 years (p<0.05), but this was not observed in the control subjects. No risk factors were associated with T. gondii seropositivity in both groups. The first Australian study of its kind found T. gondii infection in Western Australia to be highly prevalent. The results also showed that there is no serological evidence of an association between T. gondii infection and T2DM in the studied subjects. Australian health authorities should focus on raising awareness of toxoplasma infection and target T. gondii transmission control. Further studies are needed to clarify the role of T. gondii in T2DM.


2015 ◽  
Vol 16 (4) ◽  
pp. S29
Author(s):  
M. Owens ◽  
H. Bulls ◽  
E. Gossett ◽  
K. Wesson-Sides ◽  
S. Terry ◽  
...  

2019 ◽  
Vol 26 (2) ◽  
pp. 273-279 ◽  
Author(s):  
Manuel Poyato-Borrego ◽  
Juan J Segura-Sampedro ◽  
Jenifer Martín-González ◽  
Yolanda Torres-Domínguez ◽  
Eugenio Velasco-Ortega ◽  
...  

Results of this age- and gender- matched case-control study show that the prevalence of apical periodontitis, diagnosed as radiolucent periapical lesions, is higher in patients with inflammatory bowel disease than in healthy control subjects (OR = 5.71; p = 0.0048).


1997 ◽  
Vol 25 ◽  
pp. S235-S239 ◽  
Author(s):  
Norio Matsukura ◽  
Masahiko Onda ◽  
Akira Tokunaga ◽  
Shunji Kato ◽  
Toshiro Yoshiyuki ◽  
...  

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