scholarly journals Noninvasive assessment of characteristics of novel anti-HER2 antibodies by molecular imaging in a human gastric cancer xenograft-bearing mouse model

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Wei-Ying Kuo ◽  
Jia-Jia Lin ◽  
Hung-Ju Hsu ◽  
Hong-Sen Chen ◽  
An-Suei Yang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Molecular Imaging ◽  
Mouse Model ◽  
Human Gastric Cancer ◽  
Noninvasive Assessment ◽  
Gastric Cancer Xenograft

Prevention of Growth of a Human Gastric Cancer Xenograft in Nude Mice with Anti-EGF Receptor Antibody

1993 ◽  
pp. 403-405 ◽  
Author(s):  
Akira Tokunaga ◽  
Masahiko Onda ◽  
Takeshi Okuda ◽  
Tadashi Teramoto ◽  
Tsuyoshi Oguri ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Nude Mice ◽  
Egf Receptor ◽  
Human Gastric Cancer ◽  
Receptor Antibody ◽  
Gastric Cancer Xenograft

Antitumor activity of trastuzumab in combination with chemotherapy in human gastric cancer xenograft models

2006 ◽  
Vol 59 (6) ◽  
pp. 795-805 ◽  
Author(s):  
Kaori Fujimoto-Ouchi ◽  
Fumiko Sekiguchi ◽  
Hideyuki Yasuno ◽  
Yoichiro Moriya ◽  
Kazushige Mori ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Antitumor Activity ◽  
Human Gastric Cancer ◽  
Xenograft Models ◽  
Gastric Cancer Xenograft

Endoscopic molecular imaging of early gastric cancer targeting transferrin receptor 1.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e23093-e23093
Author(s):  
Jie Tian ◽  
Yang Du
Keyword(s):  
Gastric Cancer ◽  
Molecular Imaging ◽  
Early Gastric Cancer ◽  
Diagnostic Accuracy ◽  
Transferrin Receptor ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Human Gastric Cancer ◽  
Transferrin Receptor 1

e23093 Background: Gastric cancer is primarily managed endoscopically by white light gastroscope with suboptimal diagnostic accuracy. Emerging optical imaging technologies possess great potential for improving diagnostic accuracy but currently lack imaging agents for molecular specificity. In this study, a novel ligand of transferrin receptor 1 (TfR1), human H-ferritin (HFn), was labeled with fluorescent agents to enable in vivo real-time imaging by confocal laser endomicroscopy (CLE). Methods: In vivo fluorescence imaging was performed in tumor-bearing mice from human gastric cancer cell lines using fluorescently labeled HFn nanoprobe. The HFn-FITC as molecular imaging agent was applied to the gastric cancer with confocal laser endomicroscopy (CLE) in fresh endoscopic submucosal dissection (ESD) of early gastric cancer. Results: Intravital imaging of gastric xenograft tumors revealed a specific tumor targeting effects of HFn-IRDye800CW, whereas no specific signal was observed in mice injected with free dye. An ex vivo experiment on human specimens using a rigid confocal probe showed positive fluorescent staining in ESD samples diagnosed as early gastric cancers. Our CLE evaluation correlated well with immunohistochemical findings. Conclusions: CLE can be used for in vivo, molecular analysis of early gastric cancer and to identify TfR1 expression in xenografts and human tissue samples. HFn-targeted molecular imaging could improve early detection of gastric cancer.

scholarly journals Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B-regulated gene products

2013 ◽  
Vol 92 (3) ◽  
pp. 267-276 ◽  
Author(s):  
Kanjoormana A. Manu ◽  
Muthu K. Shanmugam ◽  
Feng Li ◽  
Luxi Chen ◽  
Kodappully Sivaraman Siveen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Nude Mice ◽  
Nuclear Factor Kappa B ◽  
Human Gastric Cancer ◽  
Nuclear Factor ◽  
Gene Products ◽  
Nuclear Factor Kappa ◽  
Gastric Cancer Xenograft

Toxicometabolomics of Urinary Biomarkers for Human Gastric Cancer in a Mouse Model

2010 ◽  
Vol 73 (21-22) ◽  
pp. 1420-1430 ◽  
Author(s):  
Kyu-Bong Kim ◽  
Ji-Young Yang ◽  
Seung Jun Kwack ◽  
Kui Lea Park ◽  
Hyung Sik Kim ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Mouse Model ◽  
Urinary Biomarkers ◽  
Human Gastric Cancer
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