scholarly journals Anti-metastatic Efficacy of Traditional Chinese Medicine (TCM) Ginsenoside Conjugated to a VEFGR-3 Antibody on Human Gastric Cancer in an Orthotopic Mouse Model

2017 ◽  
Vol 37 (3) ◽  
pp. 979-986 ◽  
Keyword(s):  
Gastric Cancer ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Mouse Model ◽  
Human Gastric Cancer ◽  
Orthotopic Mouse Model

scholarly journals Tubeimoside-1 Inhibits Glioblastoma Growth, Migration, and Invasion via Inducing Ubiquitylation of MET

Cells ◽  
2019 ◽  
Vol 8 (8) ◽  
pp. 774 ◽  
Author(s):  
Jiangjun Cao ◽  
Erhu Zhao ◽  
Qingzong Zhu ◽  
Juanli Ji ◽  
Zekun Wei ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Chinese Medicine ◽  
Cell Growth ◽  
Traditional Chinese Medicine ◽  
Receptor Tyrosine Kinase ◽  
Protein Level ◽  
Migration And Invasion ◽  
Anti Cancer ◽  
Inhibit Cell Growth ◽  
Receptor Tyrosine Kinase Family

Tubeimoside-1 (TBMS1) is one of the extracts of rhizoma bolbostemmae, which has remarkable anti-cancer function in the treatment of esophagus and gastric cancer in traditional Chinese medicine. However the mechanisms of its anti-cancer function is remain unclear. In this study, we demonstrate that TBMS1 could inhibit cell growth and metastasis in glioblastoma. MET is a member of the receptor tyrosine kinase family, which amplifies frequently in various human cancers. As an important proto-oncogene, multiple inhibitors have been developed for the therapy of cancers. Here, we found TBMS1 could reduce/decrease the protein level of MET via increasing its Ubiquitination degradation. Therefore, TBMS1 is a promising compound for the treatment of glioblastoma and an inhibitor of MET.

scholarly journals Effect of Rhizoma Paridis saponin on the pain behavior in a mouse model of cancer pain

RSC Advances ◽  
2018 ◽  
Vol 8 (31) ◽  
pp. 17060-17072 ◽  
Author(s):  
Genbei Wang ◽  
Yuanxue Liu ◽  
Yu Wang ◽  
Wenyuan Gao
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Mouse Model ◽  
Cancer Pain ◽  
Pain Behavior ◽  
Cancer Drug ◽  
Anti Cancer

Rhizoma Paridis saponins (RPS) as active parts ofP. polyphyllaSmith var.yunnanensishas been used as an anti-cancer drug in traditional Chinese medicine.

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