scholarly journals Dual-responsive (pH/temperature) Pluronic F-127 hydrogel drug delivery system for textile-based transdermal therapy

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Sudipta Chatterjee ◽  
Patrick Chi-leung Hui ◽  
Chi-wai Kan ◽  
Wenyi Wang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dual Responsive

scholarly journals Reactive oxygen species and enzyme dual-responsive biocompatible drug delivery system for targeted tumor therapy

2020 ◽  
Vol 324 ◽  
pp. 330-340 ◽  
Author(s):  
Ning Zhao ◽  
Bingbing Ding ◽  
Ying Zhang ◽  
Jessica L. Klockow ◽  
Ken Lau ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Tumor Therapy ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Dual Responsive

scholarly journals pH and Redox Dual-Responsive MSN-S-S-CS as a Drug Delivery System in Cancer Therapy

Materials ◽  
2020 ◽  
Vol 13 (6) ◽  
pp. 1279 ◽  
Author(s):  
Yanqin Xu ◽  
Liyue Xiao ◽  
Yating Chang ◽  
Yuan Cao ◽  
Changguo Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Release Rate ◽  
Drug Loading ◽  
Impregnation Method ◽  
Amino Groups ◽  
Dual Responsive

In order to achieve a controlled release drug delivery system (DDS) for cancer therapy, a pH and redox dual-responsive mesoporous silica nanoparticles (MSN)-sulfur (S)-S- chitosan (CS) DDS was prepared via an amide reaction of dithiodipropionic acid with amino groups on the surface of MSN and amino groups on the surface of CS. Using salicylic acid (SA) as a model drug, SA@MSN-S-S-CS was prepared by an impregnation method. Subsequently, the stability, swelling properties and drug release properties of the DDS were studied by x-ray diffraction, scanning electron microscopy, Fourier transform infrared microspectroscopy, size and zeta potential as well as Brunauer–Emmett–Teller surface area. Pore size and volume of the composites decreased after drug loading but maintained a stable structure. The calculated drug loading rate and encapsulation efficiency were 8.17% and 55.64%, respectively. The in vitro drug release rate was 21.54% in response to glutathione, and the release rate showed a marked increase as the pH decreased. Overall, double response functions of MSN-S-S-CS had unique advantages in controlled drug delivery, and may be a new clinical application of DDS in cancer therapy.

A pH and hyaluronidase dual-responsive multilayer-based drug delivery system for resisting bacterial infection

2020 ◽  
Vol 527 ◽  
pp. 146806 ◽  
Author(s):  
Pirah Ayaz ◽  
Bingjie Xu ◽  
Xiansheng Zhang ◽  
Jiping Wang ◽  
Dan Yu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bacterial Infection ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dual Responsive

pH and reduction dual responsive cross-linked polyurethane micelles as an intracellular drug delivery system

RSC Advances ◽  
2014 ◽  
Vol 4 (108) ◽  
pp. 63070-63078 ◽  
Author(s):  
Shuangjiang Yu ◽  
Chaoliang He ◽  
Qiang Lv ◽  
Hai Sun ◽  
Xuesi Chen
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Reducing Agent ◽  
Acidic Environment ◽  
Dual Responsive ◽  
Intracellular Drug Delivery ◽  
System P

pH- and reduction-responsive disulfide-crosslinked polyurethane micelles (CL-PUMs) were developed. The CL-PUMs remained stable in normal PBS while selectively swelled or decomposed in response to weakly acidic environment or reducing agent.

scholarly journals Gram Scale Synthesis of Dual-Responsive Dendritic Polyglycerol Sulfate as Drug Delivery System

Polymers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 982
Author(s):  
Felix Reisbeck ◽  
Alexander Ozimkovski ◽  
Mariam Cherri ◽  
Mathias Dimde ◽  
Elisa Quaas ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Cancer Cell ◽  
Delivery System ◽  
Laser Scanning Microscopy ◽  
Cell Uptake ◽  
Confocal Laser ◽  
Hydroxyl Groups ◽  
Polymer Backbone ◽  
Dual Responsive

Biocompatible polymers with the ability to load and release a cargo at the site of action in a smart response to stimuli have attracted great attention in the field of drug delivery and cancer therapy. In this work, we synthesize a dual-responsive dendritic polyglycerol sulfate (DR-dPGS) drug delivery system by copolymerization of glycidol, ε-caprolactone and an epoxide monomer bearing a disulfide bond (SSG), followed by sulfation of terminal hydroxyl groups of the copolymer. The effect of different catalysts, including Lewis acids and organic bases, on the molecular weight, monomer content and polymer structure was investigated. The degradation of the polymer backbone was proven in presence of reducing agents and candida antarctica Lipase B (CALB) enzyme, which results in the cleavage of the disulfides and ester bonds, respectively. The hydrophobic anticancer drug Doxorubicin (DOX) was loaded in the polymer and the kinetic assessment showed an enhanced drug release with glutathione (GSH) or CALB as compared to controls and a synergistic effect of a combination of both stimuli. Cell uptake was studied by using confocal laser scanning microscopy with HeLa cells and showed the uptake of the Dox-loaded carriers and the release of the drug into the nucleus. Cytotoxicity tests with three different cancer cell lines showed good tolerability of the polymers of as high concentrations as 1 mg mL−1, while cancer cell growth was efficiently inhibited by DR-dPGS@Dox.

Sign in / Sign up

Export Citation Format

Share Document